Nonlinear Relationships Between Dietary Selenium Intake and Ischemic Heart Disease Incidence and Mortality: A Cross-Sectional and Longitudinal Ecological Study.

Objective: Selenium, an essential mineral with antioxidant properties, can potentially prevent atherosclerosis and maintain cardiovascular health. However, the association between selenium and ischemic heart disease (IHD) remains unclear. This study aimed to determine the impact of selenium on global IHD incidence (IHDi) and mortality (IHDd) over a 28-year period from 1990 to 2018, using open data for global comparisons.

The Association Between the Dietary Fatty Acid Fraction and Healthy Life Expectancy: Global Spatiotemporal Epidemiology from 2010 to 2019.

Background: As the global population ages, extending not only the life expectancy (LE) but also the healthy life expectancy (HALE) has become a critical public health objective. Dietary choices, especially the intake of various fatty acids, may play a role in achieving good health.

Objective: The aim of this study was to describe the intake of fatty acid (FA) fractions across different countries and explore its associations with HALE and LE from 2010 to 2019 according to publicly available international data.

[Factors associated with program implementation competencies used to improve health service development capacity of public health nurses: A nationwide survey of prefectures and cities with public health centers].

Objectives　Public health nurses (PHNs) are necessary in introducing evidence-based health programs to address various health challenges. This study aimed to identify the factors related to PHNs' ability to implement programs across different career-level groups.Methods　A self-administered questionnaire was administered to PHNs working in prefectures or cities with public health centers.

Global Associations of the Traditional Japanese Diet Score with Hypertension Prevalence and Systolic Blood Pressure from 2009 to 2019: A Cross-Sectional and Longitudinal Ecological Study.

Objective: Prevention and improvement of hypertension is one of the most important health issues worldwide. The traditional Japanese diet contributes to the prevention of some non-communicable diseases associated with hypertension. However, whether traditional Japanese dietary patterns are associated with hypertension prevalence and systolic blood pressure (SBP) worldwide remains unknown.

Traditional japanese diet score and the sustainable development goals by a global comparative ecological study.

Background: Reducing the environmental impact of the food supply is important for achieving Sustainable Development Goals (SDGs) worldwide. Previously, we developed the Traditional Japanese Diet Score (TJDS) and reported in a global ecological study that the Japanese diet is associated with reducing obesity and extending healthy life expectancy etc. We then examined the relationship between the TJDS and environmental indicators.

Global Association between Traditional Japanese Diet Score and All-Cause, Cardiovascular Disease, and Total Cancer Mortality: A Cross-Sectional and Longitudinal Ecological Study.

Objective: Studies conducted on Japanese people have suggested that a traditional Japanese diet contributes to good health, longevity, and protection against several non-communicable diseases. However, it is unknown whether traditional Japanese dietary patterns are associated with all-cause mortality, cardiovascular disease, and cancer mortality globally. The purpose of this cross-sectional and longitudinal ecological study is to clarify the global association between the traditional Japanese diet score (TJDS) and all-cause, cardiovascular disease, and total cancer mortality.

Change in the association between coffee intake and ischemic heart disease in an international ecological study from 1990 to 2018.

In previous observational studies, the association between coffee intake and risk of cardiovascular disease has reversed from positive to negative over time. This long-term international ecological study examined whether the association between coffee intake and mortality and incidence rates of ischemic heart disease (IHD) changed between 1990 and 2018 using multiple coherent data. We obtained data on coffee intake per capita, IHD mortality and incidence rates per 100,000 population, and socioeconomic and lifestyle indicators for each country from various publicly available databases.

Trends in age-standardised prevalence of type 2 diabetes mellitus according to country from 1990 to 2017 and their association with socioeconomic, lifestyle and health indicators: An ecological study.

Background: There is a need for global public health strategies to effectively curb the ever-growing global diabetes population. This longitudinal ecological study was conducted to elucidate the country-specific trends of the age-standardised prevalence of type 2 diabetes mellitus (T2DM) and their association with socioeconomic, lifestyle and health indicators.

Methods: Data pertaining to the age-standardised prevalence of T2DM (rates per 100 000) and socioeconomic, lifestyle and health indicators were obtained from several international databases.

Global relationship between Mediterranean diet and the incidence and mortality of ischaemic heart disease.

Background: The purpose of this study was to clarify the global relationship between the Mediterranean diet score (MDS) and country-wise incidence and mortality of ischaemic heart disease (IHD) using an international database.

Methods: We used population data from a global longitudinal database covering 137 countries with a population of over one million. MDS were evaluated based on the total score of the nine foods that comprise the Mediterranean diet.

A longitudinal association between the traditional Japanese diet score and incidence and mortality of breast cancer-an ecological study.

Background: The traditional Japanese diet is considered one of the important factors of health and longevity in Japanese people. Breast cancer is the most common cancer among women in the world. However, the association between the traditional Japanese diet and breast cancer is unclear.

xCT Inhibition Increases Sensitivity to Vorinostat in a ROS-Dependent Manner.

As histone deacetylase inhibitors (HDACIs) have limited efficacy against solid tumors, we investigated whether and how oxidative stress is involved in sensitivity to HDACIs to develop a novel therapeutic option of HDACIs treatment. We first tested whether a reduction of the antioxidant glutathione (GSH) by glutamine deprivation affects sensitivity to a commercially available HDACI vorinostat and reactive oxygen species (ROS) accumulation. Next we investigated the relationship between a glutamate-cystine transporter xCT and the efficacy of vorinostat using siRNA of xCT and bioinformatic analyses.

Mismatch repair systems might facilitate the chromosomal recombination induced by N-nitrosodimethylamine, but not by N-nitrosodiethylamine, in Drosophila.

Mismatch repair (MMR) systems play important roles in maintaining the high fidelity of genomic DNA. It is well documented that a lack of MMR increases the mutation rate, including base exchanges and small insertion/deletion loops; however, it is unknown whether MMR deficiency affects the frequency of chromosomal recombination in somatic cells. To investigate the effects of MMR on chromosomal recombination, we used the Drosophila wing-spot test, which efficiently detects chromosomal recombination.

Mediterranean diet score and incidence of IHD: a global comparative study.

Objective: The aim of the present study was to clarify the global relationship between Mediterranean diet score (MDS) and the incidence of IHD by country using international statistics.

Design: The incidence of IHD by country was derived from the Global Burden of Disease (GBD) database. Average supplies of food (g/d per capita) and energy (kcal/d per capita) by country, excluding loss between production and household, were obtained from the FAOSTAT database.

Dietary diversity and healthy life expectancy-an international comparative study.

Background/objectives: The prolongation of healthy life expectancy (HALE) is a core issue of health policy in many countries. The purpose of this study is to clarify the relationship between dietary diversity and HALE using international databases.

Materials/methods: HALE data by country were derived from the Global Burden of Disease (GBD) 2015 database.

Effect of Genetic Information Regarding Salt-Sensitive Hypertension on the Intent to Maintain a Reduced Salt Diet: Implications for Health Communication in Japan.

The authors investigated the relationship between the awareness of dietary salt and genetics and the intent to maintain a low-salt diet. In particular, they assessed whether hypothetical genetic information regarding salt-sensitive hypertension motivates the intent to reduce dietary salt for communicating the health benefits of lower salt consumption to citizens. A self-administered questionnaire survey was conducted with 2500 randomly sampled residents aged 30 to 69 years living in Nagahama, Japan.

Experiences and attitudes of residents regarding a community-based genome cohort study in Japan: a population-based, cross-sectional study.

Background: Because of the rapid development in genomics, more research findings have emerged. However, the association between society and research results remains controversial. This article examines the experiences and attitudes of residents regarding a community-based genomic cohort study.

Residents' awareness and attitudes about an ongoing community-based genome cohort study in Nagahama, Japan.

This study's objective was to examine residents' attitudes toward and factors associated with an ongoing, real genome cohort study based on a community in Japan. After the genome cohort study's launch in 2007, in November and December 2009, a self-administered questionnaire survey was conducted with 2500 randomly sampled residents aged 30-74 years, living in Nagahama, Japan. Responses were received from 1363 people (response rate = 54.

Social capital and health: implication for health promotion by lay citizens in Japan.

A non-profit organization was formed in 2009 by lay citizens of Nagahama, Japan in response to a community-based genome-epidemiologic study, the 'Nagahama Zero(0)-ji Prevention Cohort Project (N0PCP)'. This organization aims to promote health by taking advantage of citizens' social networks. The Ottawa Charter for Health Promotion affirms the importance of creating supportive environments and coordinating social relationships.

Breastfeeding information in midwifery textbooks in Japan: content analysis with evaluation standards based on Delphi method.

The purpose of this study was to evaluate breastfeeding information in midwifery textbooks. Evaluation standards were developed in order to perform content analysis. A 3-round Delphi method using a panel of 32 midwives resulted in 36 evaluation items from the original 38 draft items based on 4 major international guidelines and statements on breastfeeding.

Evaluation of weight loss in the community-dwelling elderly with dementia as assessed by eating behavior and mental status.

Involuntary weight loss is a symptom of protein energy malnutrition often reported among elderly people, especially those with dementia. In this study, we examined whether dementia-related eating difficulties increase the probability of weight loss in the elderly. This cross-sectional observation study was conducted in 60 community-dwelling elderly people with dementia (84.