Compression of a confined semiflexible polymer under direct and oscillating fields.

The folding transition of biopolymers from the coil to compact structures has attracted wide research interest in the past and is well studied in polymer physics. Recent seminal works on DNA in confined devices have shown that these long biopolymers tend to collapse under an external field, which is contrary to the previously reported stretching of the chain. In this work, we capture the compression of a confined semiflexible polymer under direct and oscillating fields using a coarse-grained computer simulation model in the presence of long-range hydrodynamics.

Baseline neurocognitive dysfunction is ubiquitous in intrinsic brain tumors- results from a large Indian cohort of patients and analysis of factors associated with domain-specific dysfunction.

Background: Neurocognitive function (NCF) before surgery is an important marker of baseline performance in patients with brain tumors. Increasingly, neurocognitive deficits (NCD) have been demonstrated in a high proportion of patients. Selection bias (patient, tumor, and surgical procedure related) may influence the prevalence and type of domains involved in patients with gliomas.

Explicit characterization of counterion dynamics around a flexible polyelectrolyte.

The article presents a comprehensive study of counterion dynamics around a generic linear polyelectrolyte chain with the help of coarse-grained computer simulations. The ion-chain coupling is discussed in the form of binding time, mean-square displacement (MSD) relative to the chain, local ion transport coefficient, and spatiotemporal correlations in the effective charge. We have shown that a counterion exhibits subdiffusive behavior 〈δR^{2}〉∼t^{δ}, δ≈0.

Force driven transition of a globular polyelectrolyte.

We have systematically studied behavior of a flexible polyelectrolyte (PE) chain with explicit counterions, subjected to a constant force at the terminal ends. Our simulations reveal that in the hydrophobic regime, a PE globule abruptly opens to a coil state beyond a critical force F. At the transition point, the polymer shape shows large scale fluctuations that are quantified in terms of end-to-end distance R.