Publications by authors named "Kaylia M Reynolds"
Unlabelled: Diabetes has a large medical and public health impact in American Indians. Studies have used genetic data to distinguish type 1 diabetes (T1D) and type 2 diabetes (T2D) and uncover biologic mechanisms underlying T2D clinical heterogeneity. We applied a T1D polygenic score (PS) to 3,084 American Indians (mean age 56 years, 58% women, 39% diabetes).
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- This study explores how genetic variation and environmental factors influence metabolic pathways and disease risks in Hispanic/Latino individuals, particularly focusing on their distinct ancestries.
- Researchers analyzed 640 metabolites in a large cohort, identifying significant associations between specific metabolites and ancestry-derived genomic regions using advanced mass spectrometry techniques.
- Key discoveries include finding that Native American and African ancestry regions are linked to the quantity of certain metabolites, which could have implications for understanding common diseases affecting these populations.
Circulating Metabolites Associated with Albuminuria in a Hispanic/Latino Population.
Clin J Am Soc Nephrol
February 2023
Background: Albuminuria is associated with metabolic abnormalities, but these relationships are not well understood. We studied the association of metabolites with albuminuria in Hispanic/Latino people, a population with high risk for metabolic disease.
Methods: We used data from 3736 participants from the Hispanic Community Health Study/Study of Latinos, of which 16% had diabetes and 9% had an increased urine albumin-to-creatinine ratio (UACR).
Patients with autoimmune disorders (AD) have altered cancer risks compared to the general population. Systemic lupus erythematosus and multiple sclerosis lead to a heightened risk for hematological malignancies and decreased risk for breast, ovarian, and prostate malignancies. Often patients with autoimmune disease have dysregulated antiviral immune responses, including against oncogenic viruses.
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