Is there a direct correlation between cervical sagittal alignment and spinopelvic sagittal alignment?: an observational study from asymptomatic Indian adults.

Study Design: Observational study.

Purpose: Cervical parameters play a vital role in maintaining global spinal sagittal alignment, but their correlation with spinopelvic parameters remains unclear. This study aimed to investigate potential direct correlations between cervical sagittal alignment and spinopelvic alignment in an asymptomatic population.

Comparison between femoral nerve block and pericapsular nerve group block as preemptive analgesia in geriatric intertrochanteric fractures: A prospective randomised controlled clinical trial.

Purpose: Regional blocks such as femoral nerve block (FNB) and Pericapsular nerve group (PENG) block are frequently used for postoperative pain relief in fractures around the hip joint. This study compares the analgesic efficacy of PENG block with FNB in the management of intertrochanteric fractures.

Methods: This randomised controlled clinical trial included patients aged 65-80 years with intertrochanteric fractures who were planned for closed reduction and cephalomedullary nailing.

Does the length of the intermediate pedicle screw influence outcome in unstable thoracolumbar burst fractures? A prospective randomized study in India.

Study Design: A prospective randomized study.

Purpose: To investigate the impact of intermediate pedicle screw length on radiological and functional outcomes in unstable thoracolumbar burst fractures (TLF) treated with short-segment posterior fixation (SSPF).

Overview Of Literature: Although intermediate screws confer biomechanical advantages, there is no consensus on the ideal intermediate screw length.

Curve magnitude and vertebral rotation influence the MRI predictability of pedicle dimensions in adolescent idiopathic scoliosis: an analysis of 1,860 pedicles.

Purpose: The purpose of the study is to assess the MRI predictability of pedicle dimensions in AIS patients with curve magnitude more than 50° and to determine the influence of curve magnitude and vertebral rotation on MRI predictability.

Methods: The study included a comparative analysis of preoperative MRI (pMRI), and intraoperative CT (iCT) scan images of surgically corrected AIS patients with a curve magnitude of more than 50°. Bilateral T2-L4 pedicle levels were evaluated to measure the chord length and isthmic diameter in pMRI and iCT axial cuts.

Deciphering the role of glial cell-specific metabolites as biomarkers in early cervical myelopathy-insights from in vivo MRS study.

Background: Early degenerative cervical myelopathy (DCM) presents a diagnostic dilemma due to its variability in presentation, overlap with other clinical conditions, and lack of specific clinical tests. Although magnetic resonance imaging (MRI) is the preferred imaging modality, its ability to detect early cervical myelopathy remains uncertain due to its inability to detect microstructural changes at an early spondylotic stage. Magnetic Resonance Spectroscopy (MRS) is a novel, noninvasive spinal imaging technique that provides metabolic and biochemical information regarding spinal cord function.

Epitheloid Osteoblastoma of C2 Vertebra as an Unusual Cause of Developmental Torticollis: A Case Report.

Case: A 12-year-old boy presented with complaints of neck pain with tilting of the neck to the left side for 6 months. Magnetic resonance imaging revealed an osteolytic lesion at the subchondral region of the C2 vertebra left lateral mass with a large central calcific nidus suggestive of osteoblastoma. He was managed by complete surgical excision of the lesion, which turned out to be epithelioid osteoblastoma.

How does cervical and cervicothoracic alignment impact horizontal gaze?

Background: Cervical sagittal alignment maintains horizontal gaze, supports the axial load of the skull, and has a reciprocal relationship to the cervicothoracic sagittal alignment. Studies are being conducted on different ethnicities, but little literature exists about cervical sagittal alignment and correlation chains in the Indian population. Therefore, we decided to study the impact of cervical and cervicothoracic alignment on horizontal gaze.

Immune-mediated regeneration of cell-free vascular grafts in an ovine model.

We developed acellular tissue engineered vessels (ATEV) using small intestine submucosa (SIS) incorporating heparin and a novel protein named H2R5. ATEVs were implanted into the arterial circulation of an ovine animal model, demonstrating high primary patency rates over a period of three months. Implanted grafts were infiltrated by host cells, the majority of which were monocytes/macrophages (MC/MΦ), as demonstrated by scRNA sequencing and immunostaining.

The Association of Modic Changes and Disc-Endplate-Bone Marrow Complex Classification in Patients With Cervical Degenerative Disc Disease.

Study designObservational cohort study.ObjectiveTo assess the association of Modic changes and DEBC classification in patients with cervical degenerative disc disease.MethodsThe study includes 2 groups, neck pain patients presenting to the out-patient services (neck pain group) (n = 301) and polytrauma patients without cervical spine injury or a history of neck pain, who underwent whole spine MRI (control group) (n = 200).

ISSLS Prize in Clinical Science 2025: Cartilage End Plate Defects Precede and Initiate Bony End Plate Defects and Disc Degeneration- An 'Integrated Total End Plate Score' Identify Preclinical Discs at Risk for Degeneration.

Purpose: We utilized the Fast Low Angle Shot (FLASH) sequence to document the sequential changes in cartilaginous (CEP) and bony end plate (BEP) to study the influence on disc degeneration (DD).

Methods: Routine MRI and FLASH sequences were used in 500 lumbar discs in 100 each of healthy volunteers (HV), low back pain patients treated conservatively (CG) and surgically (SG) to document CEP and BEP status, Pfirrmann Grade (PG) and various MRI parameters.

Results: The three groups were identical demographically but had a significantly different number of healthy discs (p < 0.

Naltriben promotes tumor growth by activating the TRPM7-mediated development of the anti-inflammatory M2 phenotype.

Macrophage plasticity is critical for maintaining immune function and developing solid tumors; however, the macrophage polarization mechanism remains incompletely understood. Our findings reveal that Mg entry through distinct plasma membrane channels is critical to macrophage plasticity. Naïve macrophages displayed a previously unidentified Mg dependent current, and TRPM7-like activity, which modulates its survival.

Surgical Correction of Thoracic and Thoracolumbar TB Kyphosis by Posterior Only Approach Using Rajasekaran's Kyphosis Classification.

Study designProspective analysis of retrospective data.ObjectivesTo analyse the clinical and radiological outcomes of thoracic and thoracolumbar TB kyphosis by a posterior-only approach using kyphosis classification.MethodsPatients with thoracic and thoracolumbar spinal TB who underwent posterior-only surgical correction for kyphotic deformity >30° were categorized into Group: A (Active TB) and Group B (Healed TB).

Role of Magnetic Resonance Spectroscopy and T2 Relaxometry as Imaging Biomarker of Early Lumbar Intervertebral Disc Degeneration.

Study DesignObservational comparative study.ObjectiveTo study the role of magnetic resonance spectroscopy (MRS) and T2 relaxometry (T2r) as imaging biomarkers for identifying early lumbar disc degeneration.MethodsWe evaluated 236 discs in normal volunteers and 215 discs in low back pain (LBP) patients by MRS and T2r to document the molecular spectra of various metabolites as well as disc hydration and collagen content, respectively.

"Elucidating the immunomodulatory role of endocannabinoids in intervertebral disc degeneration".

Purpose: The endocannabinoid system (ECS) has been well-established to play a crucial role in the regulation of several physiological processes as well as many inflammatory disease conditions. However, its role in intervertebral disc degeneration has been least explored. We aim to investigate the immunomodulatory role of endocannabinoids in regulating IVD health.

Identification of extracellular matrix proteins in plasma as a potential biomarker for intervertebral disc degeneration.

Purpose: Recently, there has been significant focus on extracellular matrix proteolysis due to its importance in the pathological progression of intervertebral disc degeneration (IVDD). The present study investigates the circulating levels of extracellular matrix proteins in the plasma of IVDD and determines their potential relevance as biomarkers in disc degeneration.

Methods: Global proteomic analysis was performed in the plasma samples of 10 healthy volunteers (HV) and 10 diseased subjects (DS) after depletion of highly abundant proteins such as albumin and IgG.

From Modic to Disc Endplate Bone Marrow Complex - The Natural Course and Clinical Implication of Vertebral Endplate Changes.

Study Design: Review article.

Objectives: A review of literature on the epidemiology, natural course, pathobiology and clinical implications of vertebral endplate changes.

Methods: A literature search was performed using the Cochrane Database of Systematic Reviews, EMBASE, and PubMed.

Microfluidic extensional flow device to study mass transfer dynamics in the polymer microparticle formation process.

Polymer microparticles are often used to encapsulate drugs for sustained drug-release treatments. One of the ways they are manufactured is by using a solvent extraction process, in which the polymer solution is emulsified into an aqueous bulk phase using a surfactant as a stabilizing agent, followed by the removal of the solvent. The radius of a polymer drop decreases as a function of time until the polymer reaches the gelling point, after which it is separated and dried.

Risk predictive score and cord morphology classification for intraoperative neuromonitoring alerts in kyphosis surgery.

Background: Intraoperative neuromonitoring (IONM) alert is one of the worrying events of kyphosis corrective surgery, which can result in a postoperative neurological deficit. To our knowledge, there is no risk prediction score to predict such events in patients undergoing kyphosis surgery.

Purpose: To develop a new preoperative MRI-based cord morphology classification (CMC) and risk prediction score for predicting IONM alerts in patients with kyphotic deformity.

Does the gut microbiome influence disc health and disease? The interplay between dysbiosis, pathobionts, and disc inflammation: a pilot study.

Background Context: Gut microbiome alterations resulting in inflammatory responses have been implicated in many distant effects on different organs. However, its influence on disc health is still not fully investigated.

Purpose: Our objective was to document the gut biome in healthy volunteers and patients with disc degeneration and to understand the role of gut dysbiosis on human disc health.

Neuromonitoring Signal Changes in Degenerative Cervical Myelopathy: An Analysis of Risk Factors for Signal Drops During Posterior Cervical Decompression.

Objective: To analyze intraoperative neuromonitoring data of patients with degenerative cervical myelopathy undergoing cervical laminectomy and assess the incidence of signal drops and their risk factors.

Methods: This retrospective observational study included patients with degenerative cervical myelopathy who underwent cervical laminectomy with intraoperative neuromonitoring between July 2018 and March 2023. We analyzed the signal changes for any correlation with the type of pathology (ossified posterior longitudinal ligament vs.

Efficacy and Safety of Ultrasound Guided Inter-semispinal Plane Block for Postoperative Analgesia in Posterior Cervical Laminectomy - A Prospective Randomised Controlled Study.

Study designProspective, randomized controlled study.ObjectiveTo assess the safety and efficacy of an ultrasound-guided ISP block for postoperative analgesia in posterior cervical laminectomy.Methods88 patients requiring posterior cervical laminectomy were randomized into two groups, those who underwent ISP block with multimodal analgesia (ISPB group) and those with only multimodal analgesia (control group).

Orthopedic postoperative infection profile and antibiotic sensitivity of 2038 patients across 24 countries - Call for region and institution specific surgical antimicrobial prophylaxis.

Purpose: Improper utilization of surgical antimicrobial prophylaxis frequently leads to increased risks of morbidity and mortality.This study aims to understand the common causative organism of postoperative orthopedic infection and document the surgical antimicrobial prophylaxis protocol across various institutions in to order to strengthen surgical antimicrobial prophylaxis practice and provide higher-quality surgical care.

Methods: This multicentric multinational retrospective study, includes 24 countries from five different regions (Asia Pacific, South Eastern Africa, Western Africa, Latin America, and Middle East).