Serum metabolic profiling of traditional Chinese medicine syndromes in patients with diarrhea-predominant irritable bowel syndrome.

Objective: The clinical symptoms of diarrhea-predominant irritable bowel syndrome (IBS-D) can be effectively improved by traditional Chinese medicine (TCM) treatment, based on the usage of specific therapies for different TCM syndromes. However, in the stage of diagnosis, the standard criteria for the classification of TCM syndrome were still deficient. Through serum metabolic profiling, this study aimed to explore potential biomarkers in IBS-D patients with different TCM syndromes, which can assist in diagnosis of the disease.

A Facile Green Synthesis of Silver Nanoparticles Based on Poly-L-Lysine.

In this paper, we report a novel synthesis method for silver nanoparticles with facilely controllable morphology under mild conditions. The particles were synthesized by reducing silver nitrate in the presence of water soluble polymer of poly-L-Lysine (PLL) which was used as reducing agent and stabilizer. Experimental results revealed that size variation and overall formation mechanism of the resulting silver particles were mostly determined by the conformation of PLL which was in turn controlled by pH of solution and temperature.

Qingchang Wenzhong Decoction Ameliorates Dextran Sulphate Sodium-Induced Ulcerative Colitis in Rats by Downregulating the IP10/CXCR3 Axis-Mediated Inflammatory Response.

Qingchang Wenzhong Decoction (QCWZD) is an effective traditional Chinese medicine prescription. Our previous studies have shown that QCWZD has significant efficacy in patients with mild-to-moderate ulcerative colitis (UC) and in colonic mucosa repair in UC rat models. However, the exact underlying mechanism remains unknown.