Lipid-based nanocarriers in combination chemotherapy: a promising strategy for advanced skin cancer management.

Skin cancer is a prevalent and life-threatening condition, increasingly influenced by environmental changes, industrialization, and genetic factors, which contribute to its rising global incidence. Conventional chemotherapy remains a cornerstone of clinical treatment; however, its efficacy is limited by challenges such as poor drug solubility, low permeability, and systemic toxicity. Combination chemotherapy, leveraging additive or synergistic effects, has emerged as a superior approach, enhancing therapeutic outcomes.