Exploring the association between lower serum BDNF levels and delayed-onset PTSD in physically injured patients with vulnerable personality traits: A two-year prospective study.

This longitudinal study investigated the relationships among serum brain-derived neurotrophic factor (sBDNF) levels, personality types, and the development of posttraumatic stress disorder (PTSD), distinguishing between earlier- and delayed-onset PTSD over two years in individuals with physical injuries. A total of 895 adults with moderate to severe injuries were recruited from a trauma center and assessed within one month post-injury. Baseline evaluations included sBDNF measurements and personality assessments using the Big Five Inventory-10, which classified participants as having either resilient or vulnerable personality types.

Associations of heart rate variability at early post-injury with later post-traumatic stress disorder over two years.

Background: This study examines the prospective associations between early post-injury heart rate variability (HRV) measures and post-traumatic stress disorder (PTSD) development over a two-year follow-up period.

Methods: Baseline HRV parameters were measured including the Standard Deviation of NN Intervals (SDNN), Root Mean Square of Successive Differences (RMSSD), Low Frequency (LF) and High Frequency (HF) bands, and LF/HF ratio. Socio-demographic and clinical covariates were also collected.

Predictors of 2-Year Trajectory of Post-Traumatic Stress Disorder Following Physical Injury.

Objectives: This study investigated post-traumatic stress disorder (PTSD) trajectories and their predictors over a 2-year period, in individuals recovering from physical injuries.

Materials And Methods: Between June 2015 and January 2021, 1,142 patients from a South Korean University Hospital Trauma Center underwent baseline evaluations, including PTSD-related measures and sociodemographic characteristics. They were subsequently followed up for PTSD using the Clinician-Administered PTSD Scale at 3, 6, 12, and 24 months.

Efficacy of Chemotherapy Following Prior PARP-Inhibitor Treatment in Patients with Ovarian Cancer.

Purpose: Considering the current lack of consensus on post-poly (adenosine diphosphate-ribose) polymerase inhibitor (PARPi) treatment strategies, this study aimed to evaluate the efficacy of subsequent therapy and compare the outcomes of regimes in patients with recurrent ovarian cancer after PARPi treatment.

Materials And Methods: This multi-center retrospective cohort study analyzed data on patients diagnosed with ovarian cancer between January 2012 and June 2023 who had previously used PARPi after first- to fourth-line platinum-based chemotherapy. The primary endpoint was progression-free survival (PFS), which was the interval between recurrence after using PARPi and subsequent recurrence in the case of recurrence.

Educational Level Modifies the Relationship between Standard Deviation of NN Intervals and Post-traumatic Stress Disorder Development over Two-years.

Objective: This study investigated how educational levels modify the relationship between the standard deviation of NN intervals (SDNN) of heart rate variability and the development of post-traumatic stress disorder (PTSD).

Methods: Participants with physical injuries were enrolled from a trauma center and monitored over two years. Initial assessments included SDNN and educational attainment, along with socio-demographic and clinical variables.

Impacts of heart rate variability on post-traumatic stress disorder risks after physical injuries: amplification with childhood abuse histories.

Introduction: This study examined the moderating effects of childhood abuse histories on the associations between low frequency (LF) and high frequency (HF) components of heart rate variability (HRV) and the development of post-traumatic stress disorder (PTSD).

Methods: Participants with physical injuries were recruited from a trauma center and followed for two years. Baseline assessments included LF, HF, and childhood abuse histories, assessed using the Nemesis Childhood Trauma Interview.

Mismatch repair, p53, and L1 cell adhesion molecule status influence the response to chemotherapy in advanced and recurrent endometrial cancer.

Objective: This study aimed to identify the recurrence and survival rates according to the mismatch repair (MMR), p53, and L1 cell adhesion molecule (L1CAM) status in patients with advanced and recurrent endometrial cancer (EC) receiving systemic chemotherapy.

Methods: This single-center retrospective cohort study included chemotherapy-naïve patients with advanced-stage (III/IV) or recurrent EC between January 2015 and June 2022 (n = 156), who were administered chemotherapy as adjuvant therapy or first-line palliative treatment. MMR and p53 status were assessed, and L1CAM was tested using immunohistochemistry in the p53-wild and MMR-proficient (p53wt/pMMR) group.

Longitudinal associations between early post-injury serum BDNF levels and the development of post-traumatic stress disorder over two years.

Background: This study investigated the longitudinal associations between serum BDNF (sBDNF) levels measured early after injury and the onset of post-traumatic stress disorder (PTSD) across two years.

Methods: Patients with moderate to severe physical injuries were enrolled from a trauma center. At baseline, sBDNF levels were measured and a comprehensive socio-demographic and clinical data were collected.

Unique immune characteristics and differential anti-PD-1-mediated reinvigoration potential of CD8 TILs based on mutation status in epithelial ovarian cancers.

Background: We aimed to investigate the distinct immunological characteristics of the tumor immune microenvironment in epithelial ovarian cancer (EOC) according to mutations status and differential PD-1 expression levels.

Methods: Tumor-infiltrating lymphocytes (TILs) were collected from patients with newly diagnosed advanced-stage EOC (YUHS cohort, n=117). This YUHS cohort was compared with The Cancer Genome Atlas (TCGA) data for ovarian serous cystadenocarcinoma (n=482), in terms of survival outcomes and immune-related gene profiles according to status.

Clinical relevance of vaginal natural orifice transluminal endoscopic surgery (vNOTES) in gynecology.

This study reviews the progress and recent advances in vaginal natural orifice transluminal endoscopic surgery (vNOTES) as a minimally invasive gynecologic procedure. The proposed advantages of vaginal natural orifice transluminal surgery include enhanced cosmesis due to a scarless procedure, better exposure compared with the pure vaginal approach, tolerable pain scores, fewer perioperative complications, and a shorter hospital stay. Recent advances in surgical instrumentation and technology have improved the feasibility of vNOTES as an innovative treatment option for gynecological conditions.

Modifying effect of the serum level of brain-derived neurotrophic factor (BDNF) on the association between methylation and long-term cardiovascular outcomes in patients with acute coronary syndrome.

Introduction: This study investigated the potential modifying effects of the serum brain-derived neurotrophic factor (sBDNF) level on the association between methylation status and long-term cardiovascular outcomes in acute coronary syndrome (ACS) patients.

Methods: From 2006 to 2012, hospitalized ACS patients were consecutively recruited. The sBDNF level and methylation status were assessed at baseline in 969 patients who were followed up for major adverse cardiac events (MACEs) over 5-12 years, until 2017 or death.

Modifying Effect of the Interleukin-18 Level on the Association between Methylation and Long-Term Cardiovascular Outcomes in Patients with Acute Coronary Syndrome.

This study investigated the potential modifying effects of the level of the serum interleukin-18 (IL-18) on the association between methylation status and long-term cardiovascular outcomes in patients with acute coronary syndrome (ACS). Hospitalized ACS patients were recruited sequentially from 2006 to 2012. At baseline, the IL-18 level and methylation status were evaluated in 969 patients who were followed for major adverse cardiac events (MACEs) for 5-12 years, until 2017 or death.