Cross-cultural validation of the Fukushima lumbar spinal stenosis scale in Korean patients with degenerative lumbar spinal stenosis.

Background: The Fukushima Lumbar Spinal Stenosis Scale (FLS-25) is a disease-specific patient-reported outcome measure developed to assess the symptoms and functional impact of lumbar spinal stenosis (LSS). However, no Korean version of the FLS-25 has been validated to date. This study aimed to assess the reliability, validity, and responsiveness of a Korean adaptation of the FLS-25 (K-FLS-25) using a structured cross-cultural adaptation process.

Elevated extracellular water to total body water ratio and low phase angle in relation to muscle function in middle-aged and older adults.

Background: Decline in muscle function is a major health concern in aging populations, increasing the risk for disability and frailty. Bioelectrical impedance analysis (BIA) offers a practical method to assess physiological status in community settings. BIA-derived parameters include the phase angle (PhA), an indicator of cellular health and integrity, and the extracellular water to total body water (ECW/TBW) ratio, which reflects fluid balance and systemic inflammation.

The relationship between gait profile and spino-pelvic alignment in patients with adolescent idiopathic scoliosis of Lenke type 1 and 5.

Adolescent idiopathic scoliosis (AIS) is a complex three-dimensional structural deformity of the spine. While studies have reported gait abnormalities in AIS patients and their impact on patients' quality of life, the interrelationship between the sagittal spino-pelvic alignment and gait kinematics has not yet been elucidated. The purpose of this study is to investigate the association between gait profile and sagittal alignment in AIS patients, especially with Lenke type 1 and 5 curve deformities.

Bidirectional Relationship among Cognitive Function, Muscle Mass, and Grip Strength in Older Adults: the BUSAN Study.

Background: With the increasing number of older individuals, understanding the interplay among muscle strength, muscle mass, and cognitive functions in aging populations is important. This study aimed to investigate the relationships among muscle mass, muscle strength, and cognitive function among older adults, with a focus on understanding the bidirectional correlations among these factors.

Methods: A total of 335 participants aged ≥65 years were analyzed.

Lipid metabolism in cancer stem cells: reprogramming, mechanisms, crosstalk, and therapeutic approaches.

Cancer stem cells (CSCs) are a highly plastic subpopulation of tumor cells with capabilities for self-renewal, therapy resistance, and metastasis. Recent evidence highlights lipid metabolic reprogramming as a central mechanism supporting these malignant traits. This review synthesizes current findings on key lipid metabolic processes in CSCs-including lipid uptake via CD36, intracellular storage in lipid droplets, de novo fatty acid synthesis by fatty acid synthase (FASN), fatty acid oxidation (FAO) regulated by carnitine palmitoyltransferase 1A (CPT1A), and cholesterol biosynthesis through the mevalonate pathway.

Neuromonitoring of recurrent laryngeal nerve using continuous intraoperative neuromonitoring system during anterior cervical spine surgery: A porcine model study.

Purpose: Recurrent laryngeal nerve (RLN) injury is a recognized complication of anterior cervical spine surgery (ACSS), particularly during anterior cervical discectomy and fusion (ACDF). This study explores the use of continuous intraoperative neurophysiological monitoring (CIONM) with an endotracheal electromyography (EMG) tube during ACSS in a porcine model, focusing on adverse EMG signal events during retraction and the differences in RLN injury and recovery between surgical levels and approach side (left or right).

Materials And Methods: All 12 pigs were intubated with an EMG-equipped endotracheal tube.

Impact of asymmetric L4-L5 facet joint degeneration on lumbar spine biomechanics using a finite element approach.

This study investigated the effects of asymmetric facet joint degeneration on spinal behavior and adjacent structures using finite element analysis (FEA). Facet joints play a critical role in providing spinal stability and facilitating movement. Degenerative changes in these joints can lead to reduced spinal function and pain.

Validation of the Korean version of the Bad Sobernheim stress Questionnaire-Brace in adolescent idiopathic scoliosis.

This study aimed to evaluate the validity and reliability of the newly adapted Korean version of the Bad Sobernheim Stress Questionnaire-Brace (K-BSSQ-Brace). The original German BSSQ-Brace was translated, back-translated, and underwent a comprehensive cross-cultural adaptation process. The K-BSSQ-Brace and the previously validated Korean version of the Scoliosis Research Society-22 Outcomes Questionnaire (K-SRS-22) were then administered to 120 adolescents with idiopathic scoliosis (AIS).

Whole-Body and Segmental Phase Angles and Cognitive Function in the Older Korean Population: Cross-Sectional Analysis.

Background: Recently, the phase angle (PhA) has emerged as an essential indicator of cellular health. Most studies have examined its association with physiological conditions, such as sarcopenia, frailty, and physical function, in older populations. Simultaneously, growing attention is being paid to the clinical relevance of segmental PhAs for future applications.

Validation of the visual body image classification in adolescent idiopathic scoliosis: a retrospective study.

Study Design: A prospective study.

Purpose: To diagnose scoliosis, a visit to the hospital for radiography is typically necessary. In such cases, children with scoliosis are exposed to radiation, which may place their health at risk.

Finite element analysis of fixation stability according to reduction position for internal fixation of intertrochanteric fractures.

In recent years, finite element analysis (FEA) has been instrumental in comparing the biomechanical stability of various implants for femur fracture treatment and in studying the advantages and disadvantages of different surgical techniques. This analysis has proven helpful for enhancing clinical treatment outcomes. Therefore, this study aimed to numerically analyze fixed stability according to location using FEA.

Socioeconomic and Other Risk Factors for Retear after Arthroscopic Surgery for Nontraumatic Rotator Cuff Tear.

Few studies have investigated the socioeconomic factors associated with retear after rotator cuff repair. This study aimed to identify the risk factors, including socioeconomic factors, for rotator cuff retear in patients who underwent arthroscopic rotator cuff repair. This retrospective study included 723 patients diagnosed with full-thickness rotator cuff tears who underwent arthroscopic rotator cuff repair from March 2010 to March 2021.

Analyzing isolated degeneration of lumbar facet joints: implications for degenerative instability and lumbar biomechanics using finite element analysis.

The facet joint contributes to lumbar spine stability as it supports the weight of body along with the intervertebral discs. However, most studies on the causes of degenerative lumbar diseases focus on the intervertebral discs and often overlook the facet joints. This study aimed to investigate the impact of facet joint degeneration on the degenerative changes and diseases of the lumbar spine.

Validation of the Korean Ankylosing Spondylitis Quality of Life Questionnaire.

Background: Measuring accurate and reliable scores of quality of life in patients with ankylosing spondylitis (AS) is important in both decision-making and treatment planning for the disease. Questionnaire, The ankylosing spondylitis quality of life (ASQoL), is one of the representative tools for assessing how seriously AS patients view their disease severity, activity, as well as their overall health. To make these types of questionnaires readable and understandable, local language translation of surveys should be required.

Nanomaterials for detection of biomolecules and delivering therapeutic agents in theragnosis: A review.

Nanomaterials are emerging facts used to deliver therapeutic agents in living systems. Nanotechnology is used as a compliment by implementing different kinds of nanotechnological applications such as nano-porous structures, functionalized nanomaterials, quantum dots, carbon nanomaterials, and polymeric nanostructures. The applications are in the initial stage, which led to achieving several diagnoses and therapy in clinical practice.

Mitochondrial glutamate transporter SLC25A22 uni-directionally export glutamate for metabolic rewiring in radioresistant glioblastoma.

Glioblastoma Multiforme (GBM) is a malignant primary brain tumor. Radiotherapy, one of the standard treatments for GBM patients, could induce GBM radioresistance via rewiring cellular metabolism. However, the precise mechanism attributing to GBM radioresistance or targeting strategies to overcome GBM radioresistance are lacking.

A novel computer modeling and simulation technique for bronchi motion tracking in human lungs under respiration.

In this work, we proposed a novel computer modeling and simulation technique for motion tracking of lung bronchi (or tumors) under respiration using 9 cases of computed tomography (CT)-based patient-specific finite element (FE) models and Ogden's hyperelastic model. In the fabrication of patient-specific FE models for the respiratory system, various organs such as the mediastinum, diaphragm, and thorax that could affect the lung motions during breathing were considered. To describe the nonlinear material behavior of lung parenchyma, the comparative simulation for biaxial tension-compression of lung parenchyma was carried out using several hyperelastic models in ABAQUS, and then, Ogden's model was adopted as an optimal model.

Vitamin D in adolescent idiopathic scoliosis: a meta-analysis.

Objective: The aim of this study was to compare serum vitamin D levels in girls with adolescent idiopathic scoliosis (AIS) and controls using meta-analysis methods. We searched Medline (via PubMed), Cochrane, Scopus, and Embase databases for studies evaluating outcomes in AIS, including patient age, body mass index, bone mineral density (BMD), and serum levels of parathyroid hormone (PTH), calcium, and phosphate, published between January 2000 and June 2020. We searched for studies that were limited to humans only.

Effect of adipokine and ghrelin levels on BMD and fracture risk: an updated systematic review and meta-analysis.

Context: Circulating adipokines and ghrelin affect bone remodeling by regulating the activation and differentiation of osteoblasts and osteoclasts. Although the correlation between adipokines, ghrelin, and bone mineral density (BMD) has been studied over the decades, its correlations are still controversial. Accordingly, an updated meta-analysis with new findings is needed.

Relationships between Clinical Status and Gait Parameters in Ankylosing Spondylitis.

Background: This study aimed to identify the relationship between gait parameters and health-related quality of life (HRQOL) in patients with ankylosing spondylitis (AS).

Methods: The study group comprised 134 patients with AS and 124 patients were enrolled as controls. All study participants underwent instrumented gait analysis and completed clinical questionnaires.

Transfer learning-based ensemble convolutional neural network for accelerated diagnosis of foot fractures.

The complex shape of the foot, consisting of 26 bones, variable ligaments, tendons, and muscles leads to misdiagnosis of foot fractures. Despite the introduction of artificial intelligence (AI) to diagnose fractures, the accuracy of foot fracture diagnosis is lower than that of conventional methods. We developed an AI assistant system that assists with consistent diagnosis and helps interns or non-experts improve their diagnosis of foot fractures, and compared the effectiveness of the AI assistance on various groups with different proficiency.

DGKB mediates radioresistance by regulating DGAT1-dependent lipotoxicity in glioblastoma.

Glioblastoma (GBM) currently has a dismal prognosis. GBM cells that survive radiotherapy contribute to tumor progression and recurrence with metabolic advantages. Here, we show that diacylglycerol kinase B (DGKB), a regulator of the intracellular concentration of diacylglycerol (DAG), is significantly downregulated in radioresistant GBM cells.