Publications by authors named "Jun Takagaki"

Background: The COVID-19 pandemic had exposed university students to unusual environmental stresses. High stress levels have been reported among adolescents with depressive symptoms. Subthreshold depression is highly prevalent among university students who are at high risk of developing clinical depression and other psychiatric disorders such as eating disorders.

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Calendula ( L.), an edible and medicinal flower, faces challenges in yield uniformity and quality stability under open-field cultivation. Plant factories with artificial lighting (PFALs) are highly controlled systems that enable year-round production, efficient resource use, and consistent crop quality, making them promising for the cultivation for calendula.

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The skin's barrier function relies on the epidermis, whose structural integrity is maintained by basal stem cells that continuously renew and differentiate to form the multilayered epidermal architecture. Disruptions in epidermal differentiation underlie numerous hyperproliferative and inflammatory skin disorders. While transcriptional and epigenetic mechanisms are known to regulate the late stages of this process, the molecular events driving the early commitment to differentiation remain elusive.

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Early brain injury after a subarachnoid hemorrhage is an important prognostic factor. Aging is also an important prognostic factor of subarachnoid hemorrhage. However, the association between early brain injury and aging remains unclear.

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Article Synopsis
  • Disseminated carcinomatosis of the bone marrow is a complex condition caused by prostate cancer metastasizing to the bone marrow, which is often difficult to diagnose through imaging techniques.
  • A case study of a 75-year-old man showed that despite treatment and increasing PSA levels, the diagnosis was made using a C-choline PET/CT scan that revealed diffuse uptake in the bone marrow, while a bone scan showed little abnormality.
  • The patient's condition was confirmed through a biopsy and, despite starting docetaxel therapy, his PSA levels continued to rise, leading to his death four months after diagnosis, highlighting the aggressive nature of this metastatic cancer.
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Indoor vertical farming using artificial light has gained popularity as one solution to food problems. However, prior studies have shown that some consumers have a negative impression that crops are grown in an artificial environment. The increased use of purple Light-Emitting Diode (LED) lighting, which would make the growing environment look more artificial, may exacerbate that negative perception, leading to low acceptance of vertically farmed produce.

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Objective: This study reviewed the application of curved and bileaflet designs to pulmonary expanded polytetrafluoroethylene conduits with diameters of 10 to 16 mm and characterized this conduit on in vitro experiment, including particle image velocimetry.

Methods: All patients who received this conduit between 2010 and 2022 were evaluated. Three 16-mm conduits were tested in a circulatory simulator at different cardiac outputs (1.

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University students are in a phase during which they have various experiences typical in the academic environment and face situations that require adaptability and influence value formation. In the abnormal situation of the COVID-19 pandemic, university students' life rhythms, academic, interpersonal, and financial situations have changed drastically. In those situational cues, the value-based behavior of university students may have changed.

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Introduction And Importance: Afferent loop obstruction (ALO) can occur as a complication of gastrectomy with Billroth II or Roux-en-Y reconstruction. Conventionally, emergent surgery was performed for most cases, while endoscopic procedures for elective cases have been reported more recently. We report a unique case of ALO caused by a phytobezoar that was successfully treated by endoscopic procedures.

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Human DNA present in faecal samples can result in a small number of human reads in gut shotgun metagenomic sequencing data. However, it is presently unclear how much personal information can be reconstructed from such reads, and this has not been quantitatively evaluated. Such a quantitative evaluation is necessary to clarify the ethical concerns related to data sharing and to enable efficient use of human genetic information in stool samples, such as for research and forensics.

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Quantitative nutrient management has advantages, such as saving resources and improving nutrient utilization, compared with the conventional electrical conductivity management method. The growth and nutrient utilization of vegetables are affected by the integrated environmental conditions such as nutrient supply and light spectrum. This study investigated the effects of applied nutrient quantity (ANQ) (0.

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Magnetotransport properties of the graphene nanoribbons (GNR) that are in contact with superconductors at side edges are investigated numerically with respect to oscillations caused by the cyclotron motion. In terms of the modelling, the superconductors are incorporated as superconducting GNRs to make the Andreev reflection at the graphene-superconductor interface almost perfect. The classical commensurability oscillation appears at low magnetic fields where the cyclotron radius is larger than the width of the nanoribbons.

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Aims/introduction: Sodium-glucose cotransporter 2 inhibitors (SGLT2i) have been shown to display excellent renoprotective effects in diabetic kidney disease with macroalbuminuria/proteinuria. Regarding the renoprotective mechanism of SGLT2i, a sophisticated hypothesis was made by explaining the suppression of glomerular hypertension/hyperfiltration through the adenosine/adenosine type 1 receptor (A1R) signaling-mediated restoration of the tubuloglomerular feedback mechanism; however, how such A1R signaling is relevant for renoprotection by SGLT2i in diabetic kidney disease with proteinuria has not been elucidated.

Materials And Methods: Streptozotocin-induced diabetic CD-1 mice were injected with bovine serum albumin (BSA) and treated with SGLT2i in the presence/absence of A1R inhibitor administration.

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Nasturtium ( L.), as a medicinal plant, has a high phenolic content in its leaves and flowers. It is often used in salads as a dietary vegetable.

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The direct 4-alkoxylation of 4-iodo-1-pyrazoles with alcohols was achieved by a CuI-catalyzed coupling protocol. The optimal reaction conditions employed excess alcohol and potassium -butoxide (2 equiv) in the presence of CuI (20 mol%) and 3,4,7,8-tetramethyl-1,10-phenanthroline (20 mol%) at 130 °C for 1 h under microwave irradiation. The present method was efficiently applied to the synthesis of withasomnine and its six- and seven-membered cyclic homologs.

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The bonding performance of a surface pre-reacted glass ionomer (S-PRG) filler-containing self-adhesive flowable resin composites to enamel and dentin were evaluated using a tensile bond test with thermal cycling. Also, the quantities of various ions released from the materials were measured using ICP atomic emission spectrometry and a fluoride ion electrode. The initial bond strengths of the materials were approximately 6 MPa, and decreased after thermal cycling.

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Early reperfusion after endovascular thrombectomy is associated with an improved outcome in ischemic stroke patients; however, the time dependency in elderly patients remains unclear. We investigated the time-outcome relationships in different age subgroups. Of 2420 patients enrolled in the RESCUE-Japan Registry 2 study, a study based on a prospective registry of stroke patients with acute cerebral large-vessel occlusion at 46 centers, we analyzed the data of 1010 patients with successful reperfusion after endovascular therapy (mTICI of 2b or 3).

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Purpose: To investigate the effects of several etching products prior to the application of a one-step self-etch adhesive (1-SEA) or two-step self-etch adhesive (2-SEA) on enamel by microshear bond strength (µSBS) testing and observation of the adhesive-enamel interface.

Materials And Methods: Ground human enamel surfaces were randomly assigned to one of eight groups according to the combination of surface treatments (either no conditioner [NC], ME [Multi Etchant], EC [Enamel Conditioner], or KE [K-etchant Gel]) and adhesive (ADU [Adhese Universal] or SE2 [Clearfil SE Bond 2]). All groups were further divided into two subgroups: 0 or 10,000 thermal cycles (TC).

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Article Synopsis
  • Acrylonitrile-butadiene rubbers (NBRs) have unique properties, featuring a low glass transition temperature and a high dielectric constant compared to other rubbers.
  • The study evaluated how the sequence of the acrylonitrile (AN) monomers impacts these properties by synthesizing both random and alternating copolymers and analyzing their C-N stretching vibrations.
  • Results showed that alternating copolymers exhibited a higher dielectric constant than random ones due to greater flexibility in their structure, highlighting the significance of monomer sequence in determining the rubber's dielectric properties.
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Ruminal microorganisms play a pivotal role in cattle nutrition. The discovery of the main microbes or of a microbial community responsible for enhancing the gain of weight in beef cattle might be used in therapeutic approaches to increase animal performance and cause less environmental damages. Here, we examined the differences in bacterial and fungal composition of rumen samples of Braford heifers raised in natural grassland of the Pampa Biome in Brazil.

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Subtilisin NAT (STN), alternatively designated nattokinase, is a serine protease with potent fibrinolytic activity. In this study, we screened several foods to enhance the fibrinolytic potential of STN and identified unsaturated fatty acid-rich ones as candidates. We isolated linoleic acid as a major active compound from one of the most active foods, red pepper.

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Aim: Cognitive behavioral therapy (CBT) is known to be effective for patients with persistent somatoform pain disorder (PSPD). Improvement of negative emotions in interpersonal stressful situations has been reported to reduce PSPD-related clinical pain. However, these associations in CBT remain unclear.

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The aim of this study was to evaluate the time elapsed bond strength of the CAD/CAM resin block (CRB) to bovine dentin after alumina blasting. CRB (KATANA AVENCIA BLOCK) slices were ground with #600-SiC paper and divided into three groups according to alumina blasting pressure -0.1 MPa, 0.

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Introduction: Cartilage regeneration is a promising therapy for restoring joint function in patients with cartilage defects. The limited availability of autologous chondrocytes or chondrogenic progenitor cells is an obstacle to its clinical application. We investigated the existence and chondrogenic potential of synovial membrane-derived multilineage-differentiating stress-enduring (Muse)-like cells as an alternative cell source for cartilage regeneration.

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Although surgical left atrial (LA) volume reduction combined with mitral valve surgery and/or surgical ablation for atrial fibrillation has been reported to be effective, its long-term outcomes in the absence of mitral procedure are not well established. A 74-year-old man with two previous sternotomies-the first for pericardiectomy due to constrictive pericarditis and the second for mitral valve replacement with mechanical valve and tricuspid annuloplasty-presented with heart failure and thrombus in his giant left atrium (1291 mL), complicated by cerebral infarction. His electrocardiogram showed rate-controlled persistent atrial fibrillation.

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