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Article Abstract
The direct 4-alkoxylation of 4-iodo-1-pyrazoles with alcohols was achieved by a CuI-catalyzed coupling protocol. The optimal reaction conditions employed excess alcohol and potassium -butoxide (2 equiv) in the presence of CuI (20 mol%) and 3,4,7,8-tetramethyl-1,10-phenanthroline (20 mol%) at 130 °C for 1 h under microwave irradiation. The present method was efficiently applied to the synthesis of withasomnine and its six- and seven-membered cyclic homologs.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8199780 | PMC |
| http://dx.doi.org/10.3390/molecules26113370 | DOI Listing |
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