Publications by authors named "Jun Isogai"

Background: Secondary postpartum hemorrhage (PPH), which occurs between 24 h and 12 weeks postpartum, is a rare but potentially severe complication. The primary causes include retained products of conception (RPOC), subinvolution of the placental site (SIPS), and endometritis. SIPS, historically diagnosed histopathologically, is increasingly being identified using ultrasonography and angiography.

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The thymus is an important immune organ involved in T-cell generation. Age-related involution of the thymus has been linked to various age-related pathologies in recent studies. However, there has been no method proposed to quantify age-related thymic involution based on a clinical image.

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The patient is a 46-year-old woman who previously underwent a partial mastectomy with sentinel lymph node biopsy for a 5.6 cm diameter noninvasive breast apocrine carcinoma in the upper, inner quadrant right breast at age 33. Thirteen years later, a 2.

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A 75-year-old female patient presented to our hospital with a chief complaint of anemia and leg edema caused by poor nutritional status because of difficulties in oral intake. Computed tomography imaging revealed no evidence of distant metastasis, and the tumor was considered to be curatively resectable. However, as the patient was malnourished owing to difficulty in oral intake caused by gastrointestinal stenosis, we used neoadjuvant chemotherapy to avoid the risk of perioperative complications.

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Article Synopsis
  • Takotsubo cardiomyopathy (TCM) is a rare heart condition that mimics acute coronary syndrome, presenting as chest pain and left ventricular dysfunction, and can lead to life-threatening complications like ventricular septal perforation (VSP).
  • An 87-year-old woman with symptoms suggesting acute coronary syndrome was diagnosed with TCM and VSP after imaging revealed apical ballooning and serious heart issues, despite initial indications of coronary artery blockage.
  • The case emphasizes the challenges of diagnosing TCM using traditional electrocardiographic criteria and illustrates successful management through medical treatment, showing improvement in heart function and clinical status after one year.
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An 88-year-old man underwent thoracoscopic lower lobectomy for left lung cancer at the age of 87. Ten months later, he was examined closely for abdominal distention, frequent constipation, and anemia with a decreased Hb of 6.1 g/dL.

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The patient is a 74-year-old woman. She had breast cancer(invasive ductal carcinoma, ER[+], PgR[+], HER2[-], Ki-67: 30-40%)and primary right lung cancer with lumbar metastasis, which led to the diagnosis synchronous double cancers of the breast and the lung. We decided to precede surgery for lung cancer because breast cancer was indicated hormonal receptor positive.

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Article Synopsis
  • COVID-19 can lead to acute pericarditis, which is a serious condition involving the heart and can result in pericardial tamponade, a potentially life-threatening situation.
  • A 64-year-old patient treated for COVID-19 developed hemorrhagic pericardial tamponade two weeks after initial infection, highlighting the challenges of early diagnosis when symptoms are non-specific.
  • Despite initial imaging suggesting malignancy due to abnormal lymph node swelling, further investigation revealed non-cancerous granulomas, confirming the diagnosis of COVID-19-associated acute pericarditis; the patient improved with appropriate anti-inflammatory treatment.
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Background: We describe a case of segmental arterial mediolysis in which a vessel ruptured on two consecutive days.

Case Presentation: A 69-year-old man presented with sudden-onset abdominal pain. Computed tomography showed a hematoma in the gastric wall.

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Background: Transient constrictive pericarditis (TCP) is a distinct constrictive pericarditis (CP) subtype characterized by acute pericardial inflammation and transient constrictive physiology. If left untreated, it may progress to irreversible CP requiring pericardiectomy. However, making an early diagnosis of TCP remains difficult.

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The patient underwent partial sigmoid colon resection for sigmoid colon cancer with hyper CEA blood(1,110.6 ng/mL) and concurrent liver metastases mostly in the right lobe of the liver, followed by systemic chemotherapy(SOX plus BEV). Seven courses of chemotherapy resulted in PR on imaging, and CEA was reduced to 5.

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The patient was a 79-year-old man with complaints of defecation difficulties and constipation. CT scan showed a 7.5 cm diameter mass in the lower rectum, and biopsy revealed GIST.

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Infectious aortic aneurysm (IAA) can be a rare but potentially fatal sequela of infectious inflammatory disease of the aortic wall with a high incidence of rupture. The definitive diagnosis is based on vascular imaging of the aneurysm using contrast-enhanced computed tomography (CE-CT) and identification of the causative microorganism from positive blood cultures (BCs). However, IAA remains extremely difficult to diagnose and treat in patients with prior antimicrobial treatment or with renal dysfunction.

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The novel coronavirus disease (COVID-19) has resulted in a global pandemic. Recently, COVID-19-related pneumothorax has gained attention because of the associated prolonged hospital stay and high mortality. While most cases of pneumothorax respond well to conservative and supportive care, some cases of refractory pneumothorax with persistent air leaks (PALs) do not respond to conventional therapies.

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Eosinophilic granulomatosis with polyangiitis (EGPA) is a systemic vasculitis involving small-to-medium-sized vessels characterized by asthma, vasculitis, and peripheral eosinophilia. EGPA-associated eosinophilic myocarditis (EM) occurs rarely, yet can be fatal if left untreated. Moreover, the accurate diagnosis of EGPA-associated EM without vasculitis is exceptionally difficult because of the overlapping features with EM of other causes.

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Vaccine-associated myocarditis (VAM) is a rare entity but can result in potentially serious sequelae if left untreated. However, the mechanisms of the complications of VAM and its treatment remain unclear. Herein, we report the first case of VAM related to pneumococcal immunization, presenting as a local and systemic inflammatory reaction, in which the patient developed significant secondary mitral regurgitation, resulting in acute heart failure.

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Emphysematous prostatic abscess (EPA) is an extremely rare but potentially fatal urinary tract infection (UTI). Here, we describe a case (a 69-year-old male with prediabetes) of ruptured EPA caused by a hypervirulent (hvKp) K1-ST23 strain, presenting as motor aphasia. Our patient presented with ruptured EPA concurrent with various severe systemic pyogenic complications (e.

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The patient was a 29-year-old female with a chief complaint of transient right-sided abdominal pain. A CT scan revealed homogenously contrasted tumor of 4 cm in diameter with smooth margins and clear borders in the lower part of the pancreatic head. The tumor was contrast-enhanced on MRI and stained on abdominal angiography using the proximal branch of the right colonic artery as a feeding vessel.

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Immunoglobulin G4 (IgG4)-related pericarditis, an immune-mediated fibro-inflammatory condition, is a rare yet life-threatening disease presenting with constrictive pericarditis. We describe a case of IgG4-related pericarditis presenting with epicardial nodules successfully treated with corticosteroids. This case highlights the clinical significance of assessing IgG4-related pericarditis in the diagnostic workup of pericardial masses.

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Eosinophilic myocarditis is a rare subtype of myocarditis characterized by myocardial eosinophilic infiltration, and it is potentially fatal if left untreated. Although endomyocardial biopsy (EMB) is a cornerstone for the histological diagnosis of acute eosinophilic myocarditis (AEM), as it is an invasive procedure and has a low diagnostic accuracy, the diagnosis of AEM with hemodynamic instability remains challenging. We describe a case of AEM presenting as low-flow heart failure with preserved ejection fraction (HFpEF), with rapid progression to cardiogenic shock.

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Y-Ibritumomab tiuxetan (IT) therapy is a radioimmunotherapy for indolent B-cell lymphoma. Several predictors of insufficient therapeutic effects have been reported. We performed a retrospective study at a single institute to investigate whether In SPECT/CT can predict the therapeutic effects and grade of cytopenia due to Y-IT therapy.

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A 68-year-old man having a descending colon cancer with multiple metastases of up to 9.5 cm in the right lobe of the liver(T3, N0, M1a)underwent laparoscopic colon resection for anemia control. Chemotherapy with mFOLFOX6 plus Bmab was administered postoperatively.

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Löffler's endocarditis (cardiac involvement in hypereosinophilic syndrome) is rare yet life-threatening if left untreated. We describe a case of hypereosinophilic syndrome presenting as a cardiac mass with an abnormal electrocardiogram. Diagnostic studies of the cardiac mass strongly suggested a malignant cardiac tumor invading the papillary muscle.

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We report a case of a 61-year-old man with granulomatosis with polyangiitis (GPA) complicated with refractory optic neuritis and maxillary osteomyelitis. He had been treated with prednisolone (PSL) as cryptogenic organizing pneumonia in the respiratory department for 2 years. Afterward, he complained tenderness of paranasal sinuses and rapidly progressive visual loss of the left eye.

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