Publications by authors named "Julia Goyenechea"
The precise determination of neurotransmitters and their metabolites in biological matrices is critical for research on neurological disorders, including those originated by the exposure to neurotoxic chemicals. This study presents an optimized liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method for 31 neurochemicals, including neurotransmitters, their metabolites and precursors. The method is aimed at achieving lower limits of detection (LOD) and quantification (LOQ) compared to those currently available, while simultaneously expanding the number of compounds analyzed.
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- The study investigates the secondary neurotoxicity resulting from severe organophosphorus (OP) poisoning, specifically paraoxon (POX), and its impact on cognitive functions in surviving mice.
- Mice were injected with POX followed by various treatments, resulting in high survival rates but significant neurological changes such as increased lipid peroxidation and alterations in neurotransmitter levels in key brain areas linked to memory.
- Despite no signs of depression or anxiety, the study found long-term memory impairments in the mice, highlighting the model's usefulness for exploring the effects of OP exposure and strategies to combat associated cognitive deficits.
Article Synopsis
- Fish share similar neurotransmitter pathways with humans, making them vulnerable to the effects of drugs like fluoxetine, which can lead to physiological changes.
- Study findings on zebrafish indicate that parental exposure to fluoxetine alters offspring development, causing issues such as early hatching, malformations, and behavioral impairments.
- The observed changes, including altered gene expression and neurotransmitter levels, suggest potential long-term effects that could influence multiple generations, highlighting the need for more research in this area.
Boscalid (2-Chloro-N-(4'-chlorobiphenyl-2-yl) nicotinamide), a pyridine carboxamide fungicide, is an inhibitor of the complex II of the respiration chain in fungal mitochondria. As boscalid is only moderately toxic for aquatic organisms (LC > 1-10 mg/L), current environmental levels of this compound in aquatic ecosystems, in the range of ng/L-μg/L, are considered safe for aquatic organisms. In this study, we have exposed zebrafish (Danio rerio), Japanese medaka (Oryzias latipes) and Daphnia magna to a range of concentrations of boscalid (1-1000 μg/L) for 24 h, and the effects on heart rate (HR), basal locomotor activity (BLA), visual motor response (VMR), startle response (SR), and habituation (HB) to a series of vibrational or light stimuli have been evaluated.
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