Invited Discussion on: The AestheBody Guide-A Practical Approach to AestheFill Injection Beyond the Face.

Level of Evidence V This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.

Investigating the skin wound healing potential of biodegradable polymers PDLLA and PLLA in zebrafish.

Wound healing research has advanced with biodegradable polymers as a promising treatment, especially for chronic wounds. Zebrafish offer a cost-effective, regenerative, and human-relevant model for real-time, reproducible skin repair studies. The primary objective of this study is to investigate the efficacy of biodegradable polymers, PLLA (poly-l-lactic acid) and PDLLA (poly-D, L lactic acid), in promoting skin wound healing in zebrafish, while understanding their mechanisms of action at the cellular and molecular levels.

The AestheBody Guide: A Practical Approach to AestheFill Injection Beyond the Face.

The demand for nonsurgical body rejuvenation treatments is steadily increasing. Among the available options, biostimulators have emerged as a significant and impactful solution. Common off-face areas treatable with biostimulators include the neck, chest, abdomen, buttocks, arms, thighs, knees, and hands.

Hydration and Dispersion: Two Key Steps in Six AestheFill Reconstitution Methods.

AestheFill, a biostimulator containing poly-D,L-lactic acid (PDLLA) microspheres and carboxymethyl cellulose (CMC), is supplied as lyophilized powders in vials. It must be reconstituted with sterile water for injection into homogeneous suspensions before administration. In AestheFill, PDLLA microspheres do not dissolve in water, while CMC acts as a suspender for the PDLLA microspheres.

The Differences Between Sculptra and AestheFill Reconstitution Processes.

Biostimulators have been increasingly popular for facial rejuvenation in recent years. Among them, Sculptra (based on poly-L-lactic acid (PLLA)) and AestheFill (based on poly-D,L-lactic acid (PDLLA)) are supplied as lyophilized powders in vials. Both need to be reconstituted with sterile water into homogeneous suspensions before injection.

Warm Water Soaking Followed by the Back-and-Forth Pushing: An Easy Reconstitution Method for Eliminating Micro-aggregates in AestheFill Suspension.

AestheFill is supplied as lyophilized granules in vials and requires reconstitution with sterile water for injection before use. It has various applications and is often called a versatile biostimulator. It can be used for skin texture improvement through intra-dermal injection using an automatic injector with 32G multi-needles.

A Randomized, Evaluator-Blinded, Multicenter Study to Compare Injectable Poly-D,L-Lactic Acid vs Hyaluronic Acid for Nasolabial Fold Augmentation.

Background: Injectable poly-D,L-lactic acid (PDLLA), under the brand name of AestheFill (REGEN Biotech, Inc., Seoul, South Korea), is a biocompatible, biodegradable, and biostimulatory product utilized to correct soft tissue volume loss. Its efficacy and safety have not been fully studied in a large cohort.

The AestheCode System: A Safe and Efficient Guide for AestheFill Injection.

AestheFill is a biostimulator based on poly-D,L-lactic acid. It is supplied as lyophilized powders and is referred to as a versatile biostimulator. According to the amount of water added, the suspensions can be vary in thickness which can be divided into four groups for different indications: the thickest suspension (D) for nose or chin augmentation, thick suspension (D) for deep wrinkle correction, thin suspension (D) for shallow wrinkle correction, and super-thin suspension (D) for skin rejuvenation.

Retrograde flow phenomenon of poly-D,L-lactic acid filler injection over lower eyelids.

The occurrence of 'retrograde flow along the cannula/needle tract' during filler injections has not been extensively addressed in the existing literature, possibly because it is often imperceptible unless the injection is conducted at a superficial layer. In our experience with poly-D,L-lactic acid filler for lower eyelid injections, we have observed and documented this phenomenon through the skin. This article aims to elucidate and illustrate the retrograde flow phenomenon and discuss the factors influencing it.

miR-328-3p Affects Axial Length Via Multiple Routes and Anti-miR-328-3p Possesses a Potential to Control Myopia Progression.

Purpose: We previously reported miR-328-3p as a novel risk factor for myopia through a genetic association study of the PAX6 gene. In the present study, we first explored the effects of miR-328-3p on other myopia-related genes, and then tested whether anti-miR-328-3p may be used for myopia control.

Methods: The luciferase report assay and transient transfection were used to confirm miR-328-3p target genes.

Nonsurgical lower eyelid rejuvenation using injectable poly-d,l-lactic acid in Asian patients.

Background: Filler injection for lower eyelid rejuvenation remains a difficult subject due to many complicated anatomic changes as the face ages.

Objectives: To propose an alternative, simple, and effective filler injection method in lower eyelids for Asian patients.

Methods: Any patient who has tear trough deformities, infra-orbital hollows, nasojugal grooves, dark eye circles, as well as mild eyebags is a potential candidate for this method.

Reconstitution of Injectable Poly-d,l-lactic Acid: Efficacy of Different Diluents and a New Accelerating Method.

Unlabelled: Injectable poly-d,l-lactic acid (PDLLA) is a new collagen-stimulating filler containing PDLLA microspheres and carboxymethyl cellulose. It is available as a lyophilized powder that must be reconstituted with a diluent before administration. The aims of this study were to investigate the efficacy of different diluents and a new accelerating "back-and-forth" method.