Publications by authors named "Jorge Ramon"
Background: JNJ-78306358 is a bispecific antibody that redirects T cells to kill human leukocyte antigen-G (HLA-G)-expressing tumor cells. This dose escalation study evaluated the safety, pharmacokinetics, pharmacodynamics, and preliminary antitumor activity of JNJ-78306358 in patients with advanced solid tumors.
Methods: Adult patients with metastatic/unresectable solid tumors with high prevalence of HLA-G expression were enrolled.
The identification of surfaceome proteins is a main goal in cancer research to design antibody-based therapeutic strategies. T cell engagers based on KLK2, a kallikrein specifically expressed in prostate cancer (PRAD), are currently in early clinical development. Using genomic information from different sources, we evaluated the immune microenvironment and genomic profile of prostate tumors with high expression of KLK2.
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- Urban wild boar populations in Barcelona are increasing and pose risks for zoonotic pathogens like hepatitis E virus (HEV) and antimicrobial-resistant bacteria (AMR-CAMP), along with non-zoonotic threats like African swine fever virus (ASFV).
- An Agent-Based Model (ABM) was developed to predict exposure risks and found that approximately 0.79% of the human population could be exposed to HEV and 0.80% to AMR-CAMP, highlighting the role of boar faeces in pathogen transmission.
- The study emphasizes the need for collaboration among animal, public, and environmental health sectors using a One Health approach to mitigate risks associated with the coexistence of urban wildlife and human
[Reemergence of measles. Epidemic situation in the Valencian Community during the years 2011 and 2012].
Enferm Infecc Microbiol Clin
February 2014
Measles incidence declined until becomes a sporadic reporting and infrequent notification in the last decade. The reemergence of the disease reached 744 cases in 2012, a rate of 14.50×10(5) inhabitants.
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