Climate impact and land use of processing grass-clover biomass cultivated under different nitrogen fertilization rates in green biorefinery.

European livestock sectors rely heavily on imported protein feeds, presenting challenges regarding sustainability and supply security. Green biorefineries (GBR) represent a local alternative where protein concentrates are extracted from grassland crops, but the environmental performance of these systems depends on feedstock cultivation practices. This study combined field trials and life cycle assessment (LCA) to quantify how nitrogen (N) fertilization rates, clover inclusion rates, and feedstock management (fresh vs.

Comprehensive Analysis of the First 35 Years of Pediatric Heart Transplantation in Sweden.

Background: The first 35 years of pediatric heart transplantation (pHTx) in Sweden were investigated to determine outcomes following listing and transplantation, investigate sub-populations of recipients, and describe the presence of donor-specific antibodies (DSA) in a contemporary cohort.

Methods: Swedish children < 18 years, listed from 1/1/1989 to 31/12/2023, were included. The cohort was split based on the era of transplantation (ERA I: 1989-2008, ERA II: 2009-2023).

The impact of gallstone intervention during pregnancy on maternal and perinatal outcomes: a nationwide population-based cohort study.

Background And Aims: Gallstone disease during pregnancy can have varying consequences, from mild to severe and even life-threatening. The aim was to investigate how gallstone intervention during pregnancy impacts pregnancy, delivery and the newborn child.

Methods: Pregnant patients 18-45 years identified from the Swedish National Register for Gallstone Surgery and Endoscopic Retrograde Cholangiopancreatography (GallRiks) 2009-2016 constituted the intervention group and were cross-linked with the Swedish National Medical Birth Register.

Comparing non-ischaemic heart preservation (NIHP) with ischaemic static cold storage of donor hearts in adult cardiac transplantation: study protocol for a randomised controlled trial.

Introduction: Ischaemia-reperfusion (I/R) injury remains a major challenge in heart transplantation, with mortality risk increasing significantly when allograft ischaemic time exceeds 4 hours. Non-ischaemic heart preservation (NIHP), using continuous hypothermic perfusion, has shown promise in preliminary studies for reducing I/R injury and improving outcomes. This randomised controlled trial aims to compare NIHP with standard static cold storage (SCS) in adult heart transplantation.

Pediatric heart transplantation within the Scandiatransplant region-a multinational observational study spanning 38 years.

Background: Thirty-eight years of pediatric heart transplantation (pHTx) within the Scandiatransplant organization were analyzed to describe volume trends, regional prevalence, underlying etiologies, and outcomes following listing and pHTx.

Methods: Children <18 years listed for pHTx from January 1st 1986 to December 31st 2023 were identified in the Scandiatransplant registry. The cohort was split into groups based on the era of listing (ERA I; 1986-1998, ERA II; 1999-2011, and ERA III; 2012-2023).

The predictive value of postoperative soluble urokinase plasminogen activator receptor concentration for postoperative complications following valvular surgery.

Soluble urokinase plasminogen activator receptor (suPAR) is an inflammatory marker that has been shown to predict poorer outcomes in cardiovascular disease and after cardiac surgery. The relationship between suPAR concentrations and postoperative complications after valvular surgery, however, remains unclear. This study aims to evaluate the predictive value of suPAR concentrations for infection, acute kidney injury (AKI) and prolonged mechanical ventilation after valvular surgery.

A highly efficient hybrid fiber optic laser using a cesium atom vapor cell as an optical gain medium.

A new scheme of a highly efficient hybrid laser cavity is proposed and experimentally demonstrated utilizing a hot cesium (Cs) vapor cell as an optical gain medium. The laser cavity consists of a macroscopic concave reflector (> 99% reflectivity) and a 4% Fresnel-reflecting facet of a single mode fiber (SMF). The cesium gain cell is located between these two reflectors.

Modeling and simulation of amplified spontaneous emission in single-mode-pumped Cr:ZnSe bulk amplifiers with beam propagation and equivalent input-noise seeding.

Unlabelled: We investigate and use the beam propagation method with equivalent input noise for the simulation of narrow-band amplified spontaneous emission (ASE) and signal amplification in continuous-wave Cr:ZnSe non-waveguiding "bulk" amplifiers with non-saturating signal and ASE in different configurations with weak reabsorption. Both the incident pump at 1901 nm and the signal at 2410 nm were diffraction-limited gaussian beams. We implemented the equivalent input noise as random realizations of one photon per gridpoint, and showed that this leads to one noise photon per mode.

Whole genome sequencing in early onset advanced heart failure.

The genetic contributions to early onset heart failure (HF) are incompletely understood. Genetic testing in advanced HF patients undergoing heart transplantation (HTx) may yield clinical benefits, but data is limited. We performed deep-coverage whole genome sequencing (WGS) in 102 Swedish HTx recipients.

Analysis of queries to a Swedish drug information centre identifies scientific knowledge gaps.

Drug Information Centres (DICs) are providing clinicians with evidence-based support for rational drug treatment. However, knowledge gaps in the literature may hinder DICs from offering optimal guidance. This study examined the extent and nature of these knowledge gaps and their impact on clinical pharmacological advice, using real-world query data from a Swedish regional DIC.

Donor age and ischemic time in heart transplantation - implications for organ preservation.

Background: The Organ Care System and Non-ischemic Heart Preservation methods have emerged as significant advancements in heart transplantation, designed to mitigate ischemic injury and extend preservation times. However, their high costs and logistical complexities necessitate strategic utilization.

Methods: We evaluated data from 83,761 heart transplants registered in the International Society for Heart and Lung Transplantation registry from 1988 to 2018.

International Society for Heart and Lung Transplantation Guidelines for the Evaluation and Care of Cardiac Transplant Candidates-2024.

The "International Society for Heart and Lung Transplantation Guidelines for the Evaluation and Care of Cardiac Transplant Candidates-2024" updates and replaces the "Listing Criteria for Heart Transplantation: International Society for Heart and Lung Transplantation Guidelines for the Care of Cardiac Transplant Candidates-2006" and the "2016 International Society for Heart Lung Transplantation Listing Criteria for Heart Transplantation: A 10-year Update." The document aims to provide tools to help integrate the numerous variables involved in evaluating patients for transplantation, emphasizing updating the collaborative treatment while waiting for a transplant. There have been significant practice-changing developments in the care of heart transplant recipients since the publication of the International Society for Heart and Lung Transplantation (ISHLT) guidelines in 2006 and the 10-year update in 2016.

Mapping the risk of introduction of highly pathogenic avian influenza to Swedish poultry.

Outbreaks of highly pathogenic avian influenza (HPAI) have resulted in severe economic impact for national governments and poultry industries globally and in Sweden in recent years. Veterinary authorities can enforce prevention measures, e.g.

A Prospective, Randomized, Double-Blind, Split-Face, Comparative Study to Evaluate the Efficacy and Safety of DKL23 and Juvéderm Volift for Correcting Moderate-to-Severe Nasolabial Folds.

Background: Hyaluronic acid dermal fillers are used for multiple indications, including wrinkle correction and restoration of volume/fullness.

Objectives: The aim of this study was to compare the efficacy and safety of 2 hyaluronic acid products for correcting moderate to severe nasolabial folds (NLFs).

Methods: A prospective, randomized, double-blind, split-face study was undertaken.

Diastolic Filling in Patients After Heart Transplantation Is Impaired Due to an Altered Geometrical Relationship Between the Left Atrium and Ventricle.

Background: The geometrical relationship between atrial and ventricular short-axis cross-sectional area determines the hydraulic forces acting on intracardiac blood. This is important for diastolic filling. In patients undergoing heart transplantation (HTx), the left atrium is often enlarged as a result of the standard surgical technique.

Waiting list and post-transplant outcome in Sweden after national centralization of heart transplant surgery.

Background: Previous studies have demonstrated an association between transplantation rate per center and postoperative mortality after heart transplantation. In 2011, Sweden centralized heart transplants and waiting lists, reducing the number of centers from 3 to 2. We aimed to assess the active waiting time and pre- and post-transplant mortality before and after centralization.

Pleiotropic effects of melanin pigmentation: haemoparasite infection intensity but not telomere length is associated with plumage morph in black sparrowhawks.

There is increasing recognition of the potential pleiotropic effects of melanin pigmentation, particularly on immunity, with reports of variation in haemoparasite infection intensity and immune responses between the morphs of colour-polymorphic bird species. In a population of the black sparrowhawk () in western South Africa, light morphs have a higher haemoparasite infection intensity, but no physiological effects of this are apparent. Here, we investigate the possible effects of haemoparasite infection on telomere length in this species and explore whether relative telomere length is associated with either plumage morph or sex.

Impact of prolonged storage time on homograft ultrastructures: an attempt to find optimal guidelines for homograft processing.

According to guidelines, total ischemic time for homografts at processing must be kept short to avoid degeneration. Many homografts are discarded due to practical inability to finish all steps from procurement to cryopreservation within the time limit. Although, several studies have shown that homografts with prolonged ischemic time show adequate quality and performance.

Cover crop cultivation strategies in a Scandinavian context for climate change mitigation and biogas production - Insights from a life cycle perspective.

Cover crop cultivation can be a vital strategy for mitigating climate change in agriculture, by increasing soil carbon stocks and resource efficiency within the cropping system. Another mitigation option is to harvest the cover crop and use the biomass to replace greenhouse gas-intensive products, such as fossil fuels. Harvesting cover crop biomass could also reduce the risk of elevated NO emissions associated with cover crop cultivation under certain conditions, which would offset much of the mitigation potential.

Automatic Annotation of PubMed Articles with MeSH Qualifiers.

The Medical Subject Headings (MeSH) is a comprehensive indexing vocabulary used to label millions of books and articles on PubMed. The MeSH annotation of a document consists of one or more descriptors, the main headings, and of qualifiers, subheadings specific to a descriptor. Currently, there are more than 34 million documents on PubMed, which are manually tagged with MeSH terms.

Utility of heparin-binding protein following cardiothoracic surgery using cardiopulmonary bypass.

Cardiothoracic surgery using cardiopulmonary bypass (CPB) triggers an inflammatory state that may be difficult to differentiate from infection. Heparin-binding protein (HBP) is a candidate biomarker for sepsis. As data indicates that HBP normalizes rapidly after cardiothoracic surgery, it may be a suitable early marker of postoperative infection.

Cholecystectomy and ERCP in pregnancy: a nationwide register-based study.

Objective: The objective was to examine the outcomes of cholecystectomy and endoscopic retrograde cholangiopancreatography (ERCP) during pregnancy and compare these outcomes with those in nonpregnant women of fertile age.

Summary Background Data: Although both laparoscopic cholecystectomy and ERCP are considered safe and feasible in pregnant patients, there is still concern and uncertainty regarding gallstone intervention during pregnancy. This study aimed to investigate outcomes in pregnant patients compared to outcomes in nonpregnant patients.