In Silico Identification of Possible Inhibitors for Protein Kinase B (PknB) of .

With tuberculosis still being one of leading causes of death in the world and the emergence of drug-resistant strains of (Mtb), researchers have been seeking to find further therapeutic strategies or more specific molecular targets. PknB is one of the 11 Ser/Thr protein kinases of Mtb and is responsible for phosphorylation-mediated signaling, mainly involved in cell wall synthesis, cell division and metabolism. With the amount of structural information available and the great interest in protein kinases, PknB has become an attractive target for drug development.