Publications by authors named "Jitender Gairolla"
Transporting medicines by drones in hilly terrain of Northern Himalayas in India.
J Family Med Prim Care
May 2025
Background: In certain parts of the world, the use of drones in health care is expanding to increase outreach and accessibility of health services. In India, states located in the Northern Himalayan region of the country have predominantly hilly and challenging topography, making it difficult to deliver medications and medical samples on time.
Methods: In the current study, initiatives for the use of drone technology in medicine were put into practice through a sequence of proof-of-concept trials that were conducted in a tertiary care facility in India to deliver antitubercular medications and blood products in the hard-to-reach terrain of the Himalayas and the transportation of samples to the laboratory.
Objectives: In developing nations such as India, a disparity exists between the available resources for stroke rehabilitation and the substantial burden of stroke cases. Consequently, the provision of cost-effective and multidisciplinary post-stroke rehabilitation care to stroke survivors becomes of paramount importance. The utilization of mobile applications (apps) for stroke care has been on the rise, offering a personalized and pragmatic solution with the potential for wider reach in settings constrained by limited resources.
View Article and Find Full Text PDFBackground: Currently, there are no guidelines or consensus statements about the usage of inhaled mucoactive drugs in pediatric respiratory disease conditions from an Indian perspective.
Objective: To develop a practical consensus document to help pediatricians in clinical decision-making when choosing an appropriate mucoactive drug for the management of specific respiratory disease conditions.
Methods: A committee of nine experts with significant experience in pediatric respiratory disease conditions and a microbiological expert constituted the panel.
Article Synopsis
- The study investigates the role of the Cytochrome P450 (CYP) system and specific genetic variants (CYP2C19) in ischemic stroke patients, focusing on how these genetic factors may influence stroke outcomes and recurrence.
- Two adipokines, leptin (pro-inflammatory) and adiponectin (anti-inflammatory), are highlighted for their roles in stroke pathogenesis, and their levels are measured in the patient cohort.
- Results indicate that specific genetic variants (SNP2) and certain haplotypes (AC and GT) are significantly associated with the occurrence of ischemic stroke, even when adjusting for age and sex, with notable differences observed based on haplotype and gender interaction.
Article Synopsis
- Cryptogenic strokes (CS) make up 30-40% of ischemic strokes, with paradoxical embolism from patent foramen ovale (PFO) potentially contributing to these cases, but data on this in India is limited.* -
- A study involving 57 young patients with CS and 50 healthy controls used transcranial Doppler (TCD) with bubble contrast to assess for right-to-left shunt (RLS), finding a 31% RLS prevalence in patients versus 6% in controls.* -
- Results highlight that all RLS-positive patients had superficial cortical infarcts, indicating a significant link between PFO and CS in young individuals in north India, validating TCD with bubble
Clopidogrel (CLP) is a second generation thienopyridine drug commonly used in secondary prevention of ischemic stroke (IS). Its antiplatelet response maybe variable due to genetic and non-genetic factors. Adipokines may affect platelet aggregation through ADP mediated platelet signalling.
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- The study aims to investigate the relationship between positive serology and epilepsy in a rural area of North India, amidst conflicting global research findings.
- A door-to-door survey was conducted involving nearly 42,000 people, revealing a prevalence of 5 per 1000 for active epilepsy, with many cases found in younger adults.
- The research concludes that there is no significant association between epilepsy and specific infections in this rural population, as similar antibody prevalence was observed in both individuals with epilepsy and healthy controls.
Stroke is a multifactorial disease contributing to significant noncommunicable disease burden in developing countries. Risk of stroke is largely a consequence of morbidities of diabetes, obesity, hypertension, and heart diseases. Incidence of stroke is directly proportional to body mass index.
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