Causal Network Analysis Reveals Key Brain Regions Associated With Severity in Children With Autism Spectrum Disorder.

This study aims to investigate the relationship between gray matter (GM) changes and severity in children with Autism Spectrum Disorder (ASD). We examined 113 ASD children aged 2-8 years (17 mild cases, 56 moderate cases, and 40 severe cases), as well as 110 age and sex-matched healthy controls (HC). Voxel-based morphometry (VBM) was used to compare GM density (GMD) changes between ASD and HC groups.

The value of hippocampal sub-region imaging features for the diagnosis and severity grading of ASD in children.

Background: Hippocampal structural changes in Autism Spectrum Disorder (ASD) are inconsistent. This study investigates hippocampal subregion changes in ASD patients to reveal intrinsic hippocampal anomalies.

Methods: A retrospective study from Hainan Children's Hospital database (2020-2023) included ASD patients and matched controls.