Sanqi qushi formula ameliorates podocyte injury in membranous nephropathy by inhibiting endoplasmic reticulum stress-induced ferroptosis.

Ethnopharmacological Relevance: Membranous nephropathy (MN) is a primary glomerular disease and a major cause of nephrotic syndrome in adults. According to traditional Chinese medicine (TCM) theory, "dampness" is considered a key pathogenic factor. Sanqi Qushi Formula (SQQS), developed by adding dampness-eliminating herbs to Sanqi Oral Liquid, has been shown to improve remission rates in idiopathic MN, although its pharmacological mechanisms are not yet fully clarified.

Antioxidant Effect of Ethyl Acetate Fraction from L.: Integrated Phytochemical Profiling, Network Analysis, and Experimental Validation.

L. is well known for its use in medicinal and edible homologous application. Various diseases, including those related to oxidation, are commonly treated with it.

Arechuines A-D, arecoline alkaloids from the peels of L.

Four novel arecoline alkaloid atropisomers, arechuines A-D (-), were obtained from the peels of L. Their structures were elucidated by UV, IR, MS and NMR spectra. The absolute configurations of (+)/(-)- were determined by comparing the experimental and calculated ECD spectra.

Hovendulcisic acid A-D: four novel ceanothane-type triterpenoids from stems with anticancer properties.

Sixteen ceanothane-type triterpenoids, including four new compounds-hovendulcisic acids A-D (-) -were purified from the stems of Thunb. The structures of - were confirmed by comprehensive means including ECD and quantum chemical calculations. Putative biosynthetic pathways of - were proposed, and , , and exhibited antitumor activity on A549 and MDA-MB-231 cells.

Ethyl cinnamate suppresses tumor growth through anti-angiogenesis by attenuating VEGFR2 signal pathway in colorectal cancer.

Ethnopharmacological Relevance: Kaempferia galanga Linn. is an aromatic medicinal herb with extensively applied in India, China, Malaysia and other South Asia countries for thousands of years. It has been mentioned to treat abdominal tumors.

Hovenianin A Alleviates Hepatic Fibrosis by Inhibiting the PI3K/AKT Pathway in TGF-β1-Induced HSCs Based on Network Pharmacology and Transcriptomic Analysis.

Hepatic fibrosis is a global health problem, which currently has no FDA approved antifibrotic therapy yet. This study aimed to explore the mechanism of Hovenia genus in the treatment of hepatic fibrosis by an integrative strategy combining network pharmacology analysis, molecular docking, transcriptomics and experimental validation. The traditional Chinese medicine systems pharmacology (TCMSP) database and literatures were used to collect the components of Hovenia genus.