METTL3 promotes choriocarcinoma progression by activating the miR-935/GJA1 pathway in an m6A-dependent manner.

The emerging role of microRNA-935 (miR-935) in modulating cancer progression has been recognized. However, its role in regulating choriocarcinoma (CCA) development and progression remains unknown. The present work aims to reveal the effect of miR-935 on CCA cell tumor properties and the related mechanism.

Effects of initial temperature and moisture content on heat generation during degradation of municipal solid waste.

Heat generation from degradation of organic matter in municipal solid waste (MSW) often leads to increased landfill temperature. However, it is difficult to measure environmental heat loss in laboratory and field tests; therefore, little research has been conducted to evaluate heat generation during waste degradation under different initial temperatures and moisture contents. In this study, tests were conducted to investigate the effects of initial temperature and moisture content on heat generation during waste degradation.

Engineering Properties of Novel Vertical Cutoff Wall Backfills Composed of Alkali-Activated Slag, Polymer-Amended Bentonite and Sand.

The workability, hydraulic conductivity, and mechanical properties are essential to contaminant containment performance of cementitious backfills in vertical cutoff walls at contaminated sites. This study aims to investigate the engineering properties of a novel vertical cutoff wall backfill composed of reactive magnesia (MgO)-activated ground granulated blast furnace slag (GGBS), sodium-activated calcium bentonite amended with polyacrylamide cellulose (PAC), and clean sand (referred to as MSBS-PAC). Backfills composed of MgO-activated GGBS, sodium-activated calcium bentonite, and clean sand (referred to as MSBS) were also tested for comparison purposes.

Strength Characteristics of a Smooth HDPE Geomembrane/Nonwoven Geotextile Interface Based on a Novel Ring Shear Apparatus.

This paper aims to investigate the interfacial strength characteristics, particularly the residual strength, of a high-density polyethylene smooth geomembrane (GMB-S)/nonwoven geotextile (NW GTX) interface using a novel ring shear apparatus under high normal stresses and two specimen conditions. A total of eight normal stresses (from 50 kPa to 2308 kPa) and two specimen conditions (dry and submerged at ambient temperature) are considered in this study. The reliability of using the novel ring shear apparatus to study the strength characteristics of the GMB-S/NW GTX interface was demonstrated by conducting a series of direct shear experiments with a maximum shear displacement of 40 mm and ring shear experiments with a shear displacement of 10 m.

Investigating the Deformation Characteristics of Buried High-Density Polyethylene Pipes: Considering the Effect of Sequentially Applying Pressure and Elevating Temperature.

High-density polyethylene (HDPE) materials have many applications in the municipal solid waste (MSW) landfills. HDPE gravity drainage pipes are commonly utilized in MSW landfills because of the polymer's resistance to harsh chemical conditions. When landfill wastes are freshly filled, the weight acting on the leachate collection pipe increases.

Simulation of heat transfer in a landfill with layered new and old municipal solid waste.

Due to rapid degradation of the newly filled municipal solid waste (MSW), the local temperature of the waste layer increases greatly. The mechanical parameters related to waste degradation and the deformation of high-density polyethylene (HDPE) pipes in the waste body will be affected by the elevated temperature. To predict the temperature distribution in the anaerobic landfill, a one-dimensional heat transfer model is established in this study.

Identification of Circular RNA circ_0017068 as a Regulator of Proliferation and Apoptosis in Trophoblast Cells by miR-330-5p/XIAP Axis.

Preeclampsia (PE) is a major and serious complication of pregnancy. Circular RNAs (circRNAs) have been implicated in the initiation and progression of PE. In this paper, we explored the precise actions of circ_0017068 in trophoblast cell functional properties.

Wedge method for landfill stability analysis considering temperature increase.

The increase in landfill temperature often results in shear strength reduction of both the solid waste and the liner, which leads to slope instability. However, very few landfill slope analysis methods can simultaneously consider the effect of temperature on the shear strength of the waste solid and the liner. In this study, based on the strength parameters of the liner and waste with temperature, a wedge method for translational failure analysis of landfills considering temperature increase was established.

Simulation of gas transport in a landfill with layered new and old municipal solid waste.

Average biodegradation rate of newly filled municipal solid waste (MSW) in landfills is relatively fast, and the landfill gas produced by the new MSW biodegradation can cause great variations in gas pressure. To predict the gas pressure distribution in the MSW layer, a one-dimensional gas transport model is established in this study. The following factors are considered in this model: (1) the variation of gas permeability with depth; (2) the anisotropy ratio of gas permeability; (3) the settlement caused by waste biodegradation.

Effect of gas pressure on municipal solid waste landfill slope stability.

Slope failure in municipal solid waste (MSW) landfills is a common environmental disaster that poses serious ecological and health risks. Landfill slope stability (SS) is sensitive to leachate levels and gas pressure (GP) caused by the degradation of organic material, but the extent of these combined effects remains poorly understood. In this study, a simplified landfill GP calculation method is presented and a circular slide method that considers the combined effects of leachate and GP is established.

Effect of elevated temperature on solid waste shear strength and landfill slope stability.

Slope instability occurs in landfills owing to increased internal temperatures. However, strength characteristic tests for solid waste (SW) and landfill slope stability (SS) calculations that consider temperature variations are scarce in the literature. In this study, we conducted triaxial tests on SW under a range of temperature conditions and proposed the circular slide method (CSM) for calculating SS in consideration of temperature effects.

A modified stability analysis method of landfills dependent on gas pressure.

Excessive gas pressure (GP) in landfills is a potential triggering mechanism for slope failure, which is rarely considered in analytical models. This paper presents a modified analytical model for landfill stability dependent on GP. A two-layered GP model is established to describe the GP above and below the leachate level.

Simulation of gas-leachate pressure in various tested landfills using the differential quadrature method.

The degradation of solid waste in landfills results in the coupled migration of gas and leachate through the pore spaces in waste material. The existing analytical methods cannot be used to obtain a solution for the gas-leachate coupled migration problem. This study used the differential quadrature method to solve the gas and leachate phase continuity equations considering the effect of the gas-leachate coupling.

A unit-cell model for thermal regulation of degradation of organics in solid waste.

It is a well appreciated fact that temperature is one of the key factors influencing the degradation of organics. Heat exchangers are a viable option that can be used to adjust the temperature in solid waste to an extent most suitable for waste degradation. This paper focuses on an experimental and theoretical investigation of the feasibility of using a water-circulating heat exchanger for thermal regulation of waste degradation.

A new method for determination of heavy metal adsorption parameters in compacted clay by batch tests.

Evaluation of adsorption properties of pollutants on artificial or natural clay strata is normally considered in investigations of soil and groundwater pollution. Batch adsorption tests can be used to obtain the adsorption parameters of clay particles; however, the results from these tests are usually very different from the adsorption of actual clay strata. If the adsorption parameters obtained by batch tests are used to directly evaluate the properties of adsorption of pollutants onto compacted clay, the predicted groundwater and soil pollution will be unsafe.

Effect of the leachate head on the key pollutant indicator in a municipal solid waste landfill barrier system.

In previous studies of municipal solid waste (MSW) landfill barrier systems, chemical oxygen demand has been found to be the key pollutant indicator when estimating the breakthrough time for. However, the leachate head in a municipal solid waste landfill can be very high (>10 m in some Chinese landfills). The key pollutant indicator could be different at different leachate heads.

Temperature monitoring during a water-injection test using a vertical well in a newly filled MSW layer of a landfill.

High temperature may adversely affect municipal solid waste (MSW) biodegradation and lead to an increase in the deformation of high-density polyethylene (HDPE) pipes used for the collection of leachate and landfill gas in landfills. The test in this study was to change the waste temperature around the vertical injection well by water injection using a vertical well. The test was conducted intermittently with two different flowrates in a newly filled MSW layer of a landfill.

Prototype heat exchange and monitoring system at a municipal solid waste landfill in China.

A prototype heat exchange and monitoring system was installed and operated in a newly filled municipal solid waste (MSW) landfill, located in Wuxi City, China. In this study, a test was conducted using the system to investigate the influence of heat exchange on waste temperature over three heat exchange stages. During the period of sharp increase of waste temperature, the first stage test was performed, whereas during the period of gradual increase of waste temperature, the second and third stages were performed.

Laboratory test investigations on soil water characteristic curve and air permeability of municipal solid waste.

The air permeability coefficient has a high correlation with the water content of municipal solid waste. In this study, continuous drying methodology using a tension meter was employed to construct the soil water characteristic curve of municipal solid waste (M-SWCC). The municipal solid waste air permeability test was conducted by a newly designed apparatus.

Clinical and biomechanical researches of polyetheretherketone (PEEK) rods for semi-rigid lumbar fusion: a systematic review.

Lumbar spinal fusion using rigid rods is a common surgical technique. However, adjacent segment disease and other adverse effects can occur. Dynamic stabilization devices preserve physiologic motion and reduce painful stress but have a high rate of construct failure and reoperation.

The behavior of compression and degradation for municipal solid waste and combined settlement calculation method.

The total compression of municipal solid waste (MSW) consists of primary, secondary, and decomposition compressions. It is usually difficult to distinguish between the three parts of compressions. In this study, the odeometer test was used to distinguish between the primary and secondary compressions to determine the primary and secondary compression coefficient.

One-dimensional model for municipal solid waste (MSW) settlement considering coupled mechanical-hydraulic-gaseous effect and concise calculation.

A new model entitled the coupled mechanical-hydraulic-gaseous effect and biochemical degradation for municipal solid waste (MSW) is proposed to simulate and predict the MSW settlement in this study. The coupled model can be used to simulate and predict the distributions of gas and water pressure as well as total waste settlement. Model verification indicates that because of degradation, the excess pore gas pressure increases rapidly and reaches a peak value in a short time, and then it dissipates gradually.