Publications by authors named "Jianghao Cao"
Camptothecin and its derivatives exhibit broad-spectrum antitumor activity, but their clinical application is hampered by poor water solubility, myelosuppression, and gastrointestinal toxicity. Peptide-drug conjugates (PDCs) represent the next generation of targeted therapeutic agents. In this study, we designed two RGDS-hydroxycamptothecin conjugates, 6-RGDS and 2-RGDS, which were linked via ester and ether bonds, respectively.
View Article and Find Full Text PDFYr29 combined with QYr.nwafu-4BL.3 confers durable resistance to stripe rust in wheat cultivar Jing 411.
Theor Appl Genet
October 2024
The combination of a QTL on chromosome arm 4BL and Yr29 provides durable resistance with no significant yield penalty. Wheat stripe rust or yellow rust (YR), caused by Puccinia striiformis f. sp.
View Article and Find Full Text PDFArticle Synopsis
- Stripe rust is a significant threat to wheat crops globally, and the Chinese cultivar Lanhangxuan 121 (LHX121) shows greater resistance than its parent, L92-47, owing to space mutation breeding.
- This research aimed to identify resistance genes in both LHX121 and L92-47 by creating segregating populations and analyzing their responses to stripe rust in multiple environments over two years.
- QTL mapping revealed resistance loci in both cultivars, suggesting that LHX121 may harbor a novel resistance QTL on chromosome 5B, contributing to improved understanding of wheat's genetic defenses against stripe rust.