[Clinical value of cervical mediastinoscopy in non-small cell lung cancer of stage I].

Background & Objective: Whether to apply routine mediastinoscopy to non-small cell lung cancer (NSCLC) of stage I remains controversial. This study was to evaluate application of cervical mediastinoscopy in detecting mediastinal lymph nodes status of NSCLC of stage I.

Methods: The cervical mediastinoscopy was performed in 31 patients with NSCLC of stage I prior to thoracotomy from Oct.

[Predictive value of detection of sentinel lymph nodes on lymphatic metastasis of non-small cell lung cancer].

Background & Objective: The metastasis status of regional lymph node is an important prognostic factor of non-small cell lung cancer (NSCLC). Sentinel lymph node (SLN) mapping and biopsy is a quick and high efficient technique to intraoperatively detect occult micrometastatic disease, however, its application in NSCLC is immature. This study was designed to investigate the feasibility of detecting SLN in patients with NSCLC during radical surgery, and to evaluate its accuracy of predicting metastasis status of regional lymph node.

[Clinical analysis of resectable breast cancer: a report of 6 263 cases].

Background & Objective: In Europe and America, breast cancer commonly occurs in women of middle and old age, the median age of patients is about 57 years old. Modified radical mastectomy has taken the place of traditional radical mastectomy, and is called standard radical mastectomy. Patients with breast cancer of early stage commonly receive breast conservative therapy.

[Expressions of epithelial growth factor receptor and E-cadherin in esophageal carcinoma and their correlation].

Background & Objective: Up-regulation of epithelial growth factor receptor (EGFR) and down-regulation of E-cadherin are correlated with genesis, progression, invasion, and metastasis of tumor; however,their expressions,especially their association,in esophageal carcinoma have seldom been reported. This study was to detect expressions of EGFR and E-cadherin in esophageal carcinoma, and to analyze their relationship.

Methods: Expressions of EGFR and E-cadherin in 50 specimens of esophageal squamous carcinoma and 8 specimens of esophageal adenocarcinoma were detected by immunohistochemistry.

[Analysis of the abnormal chromosome karyotype in habitual abortion].

An analysis was made of the chromosome karyotype from the peripheral blood taken from a couple who had experienced consecutive abortions for four times. The karyoype was determined as Rob(13;21) through G-band and high resolving power.

[Chemoradiotherapy followed by surgery in treatment of locally advanced esophageal carcinoma: a phase II trial].

Background & Objective: Recently, neoadjuvant therapy has become the focus of interest in an effort to prolong survival and reduce recurrence rates in patients with oesophageal cancer. This study was designed to evaluate the tolerance and the short-term outcome of chemoradiotherapy followed by surgery for patients with locally advanced esophageal squamous carcinoma, to observe effects of chemoradiotherapy on tumor resection rate, incidence of complications after surgery, and perioperative mortality.

Methods: From January 2000 to September 2003, Thirty-four consecutive patients with locally advanced esophageal squamous carcinoma were entered into this phase II study.

[Clinical evaluation of management of superior mediastinal metastasis from thyroid carcinoma with systemic superior mediastinal dissection via sternotomy approach: 12 cases report].

Background & Objective: Few research of surgery for superior mediastinal metastasis from thyroid carcinoma has been reported. Previous surgical approach from neck had the problems of easy damage of nerve and vessels and the difficulty of clearance of lymph nodes. This study was designed to assess the value of systemic superior mediastinal lymph node dissection via sternotomy for superior mediastinal metastasis from differentiated thyroid carcinoma.

[Treatment of unresectable esophageal carcinoma by stenting with or without radiochemotherapy].

Objective: To evaluate the benefits of post-stenting radiotherapy and/or chemotherapy for unresectable esophageal carcinoma.

Methods: Fifty-three patients with unresectable esophageal carcinoma were randomly divided into two groups: patients in group A (n = 27) were treated with stenting alone, and those in group B (n = 26) were treated with stenting followed by radiotherapy and/or chemotherapy. Comparison was made by assessing their survival time, quality of life (QOL), degree of dysphagia, and stenting-related morbidity, respectively.

[Shrinkage of resected specimens of esophageal carcinoma].

Background & Objective: There are some kinds of shrinkage in resected specimens of esophageal carcinoma; however,there were few reports on its regularity. This study was designed to investigate the degree of shrinkage in resected specimens of esophageal carcinoma.

Methods: Specimens of seventy patients with esophageal squamous cell carcinoma who underwent resections in Cancer Center, Sun Yat-Sen University were collected.

[Giant pathologic section in the study of optimal length of surgical resection for esophageal carcinoma].

Objective: To study the optimal surgical resection length for esophageal carcinoma.

Methods: Specimens of seventy patients with esophageal squamous cell carcinoma resected and collected in our hospital were made into pathologic giant sections. Direct intramural infiltration, multicentric carcinogenic lesion and leaping metastasis were observed in the large slice by microscope.

[Cox regression analysis of the prognostic factors of unresectable esophageal carcinoma after stenting].

Background & Objective: There are many factors affect the prognosis of the patients with unresectable esophageal carcinoma who underwent intubation, however, it is unclear which ones are main causes so far. This study was designed to analyze the prognostic factors of unresectable esophageal carcinoma after stenting in order to find the reasonable modalities of palliative therapy.

Methods: Consecutive 102 patients with unresectable esophageal carcinoma who were eligible for inclusion criteria were analyzed after stenting.

Effects of recombinant staphylokinase on coronary thrombosis in Chinese experimental miniature swine.

Aim: To study the effects of recombinant staphylokinase (r-Sak) on coronary thrombosis, cardiac ischemia, and myocardial infarction in Chinese experimental miniature swine.

Methods: Endarterium was injuried and coronary thrombi were formed gradually through direct electrical stimulation on the coronary artery of Chinese experimental miniature swine. Effects of r-Sak in vitro were studied through coronary pathological section, microkinematography, multi media graphic analysis, epicardial electrogram mapping, myocardium histo chemical stain, serum creatine phosphokinase (CPK), and hemorheology.