Crosstalk Between Microbiome and Ferroptosis in Diseases: From Mechanism to Therapy.

The human microbiome is a unique organ and maintains host immunomodulation and nutrient metabolism. Structural and functional microbiome alterations are commonly known as dysbiosis, which is strongly associated with disease progression. Ferroptosis is a novel iron-dependent cell death mode characterized by intracellular iron accumulation, increased reactive oxygen species (ROS), and lipid peroxidation (LPO).

Hospital Volume Matters: a meta-analysis of mortality after colorectal cancer surgery.

Background: Postoperative mortality serves as a critical indicator for assessing surgical safety in patients undergoing colorectal cancer surgery; however, the relationship between annually hospital surgical case volume and postoperative mortality remains unclear. Here, we aimed to investigate the volume-outcome relationship for colorectal cancer surgery and to identify potential thresholds for high-volume hospitals.

Methods: Studies reporting the association between hospital volume and postoperative mortality in colorectal cancer patients undergoing colorectal cancer surgery were systematically screened up to June 2025.

Effects of antibiotic exposure on risks of colorectal tumors: a systematic review and meta-analysis.

Background: Increasing evidence suggests that the gut microbiome may play an important role in the development of colorectal tumors. Antibiotic use can affect the gut microbiome and may increase the risks of benign and malignant colorectal tumors.

Methods: Eligible studies assessing the relationship between antibiotic exposure and the risk of developing benign or malignant colorectal tumors were identified.

Antibody-drug conjugates in gastric cancer: from molecular landscape to clinical strategies.

Antibody-drug conjugates (ADCs) represent a crucial component of targeted therapies in gastric cancer, potentially altering traditional treatment paradigms. Many ADCs have entered rigorous clinical trials based on biological theories and preclinical experiments. Modality trials have also been conducted in combination with monoclonal antibody therapies, chemotherapies, immunotherapies, and other treatments to enhance the efficacy of drug coordination effects.