Hospital Volume Matters: a meta-analysis of mortality after colorectal cancer surgery.

Background: Postoperative mortality serves as a critical indicator for assessing surgical safety in patients undergoing colorectal cancer surgery; however, the relationship between annually hospital surgical case volume and postoperative mortality remains unclear. Here, we aimed to investigate the volume-outcome relationship for colorectal cancer surgery and to identify potential thresholds for high-volume hospitals.

Methods: Studies reporting the association between hospital volume and postoperative mortality in colorectal cancer patients undergoing colorectal cancer surgery were systematically screened up to June 2025.

Macrophage polarization in cancer and beyond: from inflammatory signaling pathways to potential therapeutic strategies.

Macrophages are innate immune cells distributed throughout the body that play vital roles in organ development, tissue homeostasis, and immune surveillance. Macrophages acquire a binary M1/M2 polarized phenotype through signaling cascades upon sensing different signaling molecules in the environment, thereby playing a core role in a series of immune tasks, rendering precise regulation essential. M1/M2 macrophage phenotypes regulate inflammatory responses, while controlled activation of inflammatory signaling pathways is involved in regulating macrophage polarization.

Exposure to proton pump inhibitors and risk of diabetes: A systematic review and meta-analysis.

Background: Exposure to proton pump inhibitors (PPIs) has been reported to have a potential role in the development of diabetes.

Aim: To determine the association between PPIs and diabetes.

Methods: This meta-analysis is registered on PROSPERO (CRD42022352704).