Publications by authors named "Ji Hun Park"

Purpose: Since 1995, the Korean Gastric Cancer Association (KGCA) has been periodically conducting nationwide surveys on patients with surgically treated gastric cancer. This study details the results of the survey conducted in 2023.

Materials And Methods: The survey was conducted from March to December 2024 using a standardized case report form.

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Polyphenols form nanofilms with transition metal ions by coordination-driven assembly. The as-formed metal-polyphenol nanofilms can degrade in the presence of chelating ligands that exhibit high stability constant with the nanofilm-forming metal ions. We have demonstrated the degradation of Fe(III)-tannic acid nanofilms with hydroxyketone ligands, such as maltol, kojic acid, and deferiprone, which exhibit high availability and excellent cytocompatibility.

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  • The study investigates focused ultrasound (FUS) as a method to non-invasively deliver gold nanoparticles (AuNPs) across the blood-retinal barrier (BRB) for treating retinal disorders.
  • Researchers optimized FUS parameters to ensure effective delivery while preventing retinal damage, demonstrating the successful transportation of AuNPs and other substances to the retina in a rodent model.
  • Findings suggest that smaller AuNPs are more effective at penetrating the retinal layers, paving the way for new non-invasive therapies in the treatment of retinal diseases.
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Histiocytic sarcoma (HS) is a rare malignant neoplasm of presumed hematopoietic origin, showing morphologic and immunophenotypic evidence of histiocytic differentiation. A 61-year-old woman presented with an abdominal mass. She had a history of HS in both adrenal glands.

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Frontal fibrosing alopecia (FFA) is a scarring alopecia with fronto-temporo-parietal hairline recession. Although no proven treatment for FFA exists, dutasteride has been suggested as a potential treatment option. We aimed to evaluate the therapeutic response of oral dutasteride in FFA patients.

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  • There is a growing need for soft materials that can securely adhere to nerve tissues without the need for sutures, as this can improve surgical outcomes and recovery.
  • The development of a novel material called sticky and strain-gradient artificial epineurium (SSGAE) addresses this challenge by providing strong adhesion to wet nerves and anti-inflammatory properties.
  • The SSGAE, designed with a structure that mimics natural skin, has shown success in stabilizing nerve repairs in both rodent and nonhuman primate models, showcasing its potential for real-world medical applications in peripheral nerve repair.
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This review introduces multifaceted mutual interactions between molecules containing a catechol moiety and aggregation-prone proteins. The complex relationships between these two molecular species have previously been elucidated primarily in a unidirectional manner, as demonstrated in cases involving the development of catechol-based inhibitors for amyloid aggregation and the elucidation of the role of functional amyloid fibers in melanin biosynthesis. This review aims to consolidate scattered clues pertaining to catechol-based amyloid inhibitors, functional amyloid scaffold of melanin biosynthesis, and chemically designed peptide fibers for providing chemical insights into the role of the local three-dimensional orientation of functional groups in manifesting such interactions.

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This study aimed to develop microspheres using water-soluble carriers and surfactants to improve the solubility, dissolution, and oral bioavailability of rivaroxaban (RXB). RXB-loaded microspheres with optimal carrier (poly(vinylpyrrolidone) K30, PVP) and surfactant (sodium lauryl sulfate (SLS)) ratios were prepared. H NMR and Fourier transform infrared (FTIR) analyses showed that drug-excipient and excipient-excipient interactions affected RXB solubility, dissolution, and oral absorption.

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  • * These biodegradable materials are biocompatible, allowing the formation of protective nanostructures around probiotics without harming their viability.
  • * The enhanced protection from the developed shells, particularly with added iron, significantly boosts the viability of probiotics in harsh environments like simulated gastric fluid, showing potential for applications in both health and waste recycling.
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Background: Herpes zoster (HZ) is one of the most common cutaneous adverse reactionsassociated with the coronavirus disease 2019 (COVID-19) vaccine and has been widely reported. This study aimed to evaluate HZ following COVID-19 vaccination from the viewpointof pain management.

Methods: A retrospective study was conducted on 42 patients with HZ who visited the painclinic between August 2021 and October 2021.

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This study investigates the strength and permeability properties of pervious concrete-containing coal bottom ash (CBA) aggregates. Two pervious concrete mixtures were fabricated with different aggregate size distributions. One mixture contained CBA aggregates with a single-type distribution and the other mixture contained CBA aggregates with a hybrid-type distribution.

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  • Hepsin is a serine protease that is highly expressed in prostate cancer, making it a potential biomarker for detection, as opposed to normal prostate tissue.
  • The study involved creating a PET imaging radioligand by synthesizing six derivatives and selecting the most effective one based on its ability to bind to hepsin.
  • The developed [Cu] radioligand showed strong binding to prostate cancer cells in mice, particularly in those with 22Rv1 tumors, indicating its potential for imaging hepsin in prostate cancer.
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  • * Researchers found a clear link between air pollution levels—specifically sulfur dioxide (SO) and nitrogen dioxide (NO)—and the incidence of PAD over a 1.8 million person-years period, noting that 5243 new PAD cases were identified.
  • * The analysis indicated that long-term exposure to these pollutants significantly raises the risk of PAD, with specific hazard ratios showing a notable increase in risk linked to higher concentrations of SO and NO, even after adjusting for other influencing factors.
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Purpose: The purpose of this study was to determine whether the direct anterior approach (DAA) can be applied to hemiarthroplasty for treatment of unstable femoral intertrochanteric fractures in elderly patients.

Materials And Methods: We conducted a retrospective review of 34 cases (34 patients) who underwent bipolar hemiarthroplasty using a DAA from February 2019 to April 2020. The mean age of the patients was 82.

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Neuroinflammation involves activation of glial cells in the brain, and activated microglia play a particularly important role in neurodegenerative diseases such as Alzheimer's disease (AD). In this study, we developed 5-cyano--(4-(4-(2-[F]fluoroethyl)piperazin-1-yl)-2-(piperidin-1-yl)phenyl)furan-2-carboxamide ([F]) for PET imaging of colony-stimulating factor 1 receptor (CSF1R), an emerging target for neuroinflammation imaging. Non-radioactive ligand exhibited binding affinity comparable to that of a known CSF1R inhibitor, 5-cyano--(4-(4-methylpiperazin-1-yl)-2-(piperidin-1-yl)phenyl)furan-2-carboxamide (CPPC).

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Chemical reactions between homogeneous precursors are typically used to synthesize monodisperse nanoparticles with well-controlled size and morphology. It is difficult to predict the evolved nanostructures when using two heterogeneous precursors. In this study, three types of Mo-Te nanoparticles shaped like leaves, spindles, and rice grains (denoted respectively as nanoleaf, nanospindle, and nanorice) were obtained from dextrose-mediated proton-coupled electron transfer reaction between the solid polyoxomolybdate (POM) and the ionic tellurite anion as precursors.

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Nitric oxide (NO) has been shown to promote revascularization and nerve regeneration after peripheral nerve injury. However, in vivo application of NO remains challenging due to the lack of stable carrier materials capable of storing large amounts of NO molecules and releasing them on a clinically meaningful time scale. Recently, a silica nanoparticle system capable of reversible NO storage and release at a controlled and sustained rate was introduced.

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  • Peripheral nerve injury leads to significant motor and sensory function loss, creating increased health challenges for affected individuals, with autogenous nerve grafts currently being the standard treatment despite their limitations like donor nerve scarcity.
  • Recent advancements in regenerative medicine have led to the development of tissue-engineered nerve grafts as potential alternatives, including a novel nerve guidance conduit designed with a poly(lactide-co-ε-caprolactone) (PLCL) membrane and a 3D-printed gelatin hydrogel.
  • In tests using a rat model, this PLCL/gelatin conduit showed promising results in promoting axonal regeneration, remyelination, and functional recovery, indicating that it could effectively replace traditional autogenous nerve grafts.
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  • This study compared postoperative outcomes in patients with late-stage Kienböck disease treated with scaphocapitate arthrodesis (SCA), focusing on the effects of carpal-ulnar translation.
  • The research involved 39 patients, dividing them into translated and untranslated groups based on carpal position, and assessing various surgical factors and functional outcomes, including pain relief and range of motion.
  • It concluded that SCA effectively improves function and reduces pain, regardless of carpal-ulnar translation, but noted that significant overcorrection resulting in a radioscaphoid angle (RSA) less than 30° was more common in the translated group.
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Resveratrol (3,4',5-trihydroxystilbene) is beneficial to human health due to its diverse biological activities including its anti-inflammatory and anti-oxidative effects as confirmed by pharmacokinetic tests. Despite these clinical merits, resveratrol's limited hydrosolubility and chemical vulnerability remain challenging with regard to developing a controlled delivery system with enhanced bioavailability. In this work, we report a resveratrol-β-lactoglobulin (R-BLG) composite nanocoating through a layer-by-layer assembly with Fe(III)-tannic acid nanofilms.

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This study aims to evaluate the effect of curing and drying conditions on the strength properties of concrete containing coal bottom ash (CBA) and fly ash as substitutes for fine aggregates and cement, respectively. The strength properties of the concrete including CBA and fly ash were evaluated under two different curing and drying conditions: saturated surface-dry (SSD) conditions and oven-dried conditions at curing ages of 28 and 91 days. The natural fine aggregates of the mixtures were replaced by CBA fine aggregates at 25%, 50%, 75%, and 100% by volume.

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Impervious pavements exist in large proportions in most cities owing to the high-impact development of the transportation infrastructure. However, this type of pavement causes environmental issues such as waterlogging, floods, and urban heat islands. Pervious concrete (PC), which is a novel pavement material characterized by a porous structure that allows water to percolate through it, is an important solution to these issues.

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Progressive diabetic nephropathy (DN) in diabetes leads to major morbidity and mortality. The major pathological alterations of DN include mesangial expansion, extracellular matrix alterations, tubulointerstitial fibrosis, and glomerular sclerosis. is widely used in traditional oriental medicine and has long been used as a diuretic, astringent, insecticide and antihypertensive.

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