Publications by authors named "Jhe-Wei Lin"
Amino-Acid-Engineered Bionanozyme Selectivity for Colorimetric Detection of Human Serum Albumin.
ACS Appl Mater Interfaces
April 2025
Nanozymes are emerging nanomaterials owing to their superior stability and enzyme-mimicking catalytic functions. However, unlike natural enzymes with inherent amino-acid-based recognition motifs for target interactions, manipulating nanozyme selectivity toward specific targets remains a major challenge. In this study, we introduce the de novo strategy using the supramolecular assembly of l-tryptophan (l-Trp) as the recognition amino acid with copper (Cu) ions for creating a human serum albumin (HSA)-responsive bionanozyme.
View Article and Find Full Text PDFImporting Diffusion and Re-Designed Backward Process for Image De-Raining.
Sensors (Basel)
June 2024
In recent years, with the increasing demand for high-quality images in various fields, more and more attention has been focused on noise removal techniques for image processing. The effective elimination of unwanted noise plays a crucial role in improving image quality. To meet this challenge, many noise removal methods have been proposed, among which the diffusion model has become one of the focuses of many researchers.
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- * The study focused on the effects of docetaxel, an antitumor drug, on SAS cells from human tongue SCC, revealing that it induces cell death and activates apoptosis-related proteins.
- * Docetaxel's mechanism involves altering mitochondrial functions and activating specific signaling pathways (MAPK and AMPK), where inhibiting these pathways reduces the drug's apoptotic effects on cancer cells.
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- Chlorpyrifos (CPF) is a widely used pesticide that has been linked to neurotoxic effects, raising concerns about its role in neurodegenerative diseases.
- The study found that CPF exposure significantly reduced the viability of Neuro-2a cells and increased signs of apoptosis, including the activation of specific cellular markers like caspase-3 and CHOP.
- Findings suggest that CPF induces neuronal cytotoxicity through two independent pathways: reactive oxygen species (ROS) generation and Akt activation, both of which lead to cell death in nerve cells.
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- Ketamine-associated cystitis causes inflammation and cell death in the bladder, and its main metabolite norketamine (NK) has been shown to have even greater toxic effects on bladder cells than ketamine itself.
- In studies, exposure to NK resulted in reduced cell viability and increased apoptosis in bladder cells, linked to mitochondrial dysfunction and elevated endoplasmic reticulum (ER) stress markers.
- The study also found that inhibiting certain pathways (like ERK1/2 and calcium signaling) effectively reduced the harmful effects of NK, suggesting new avenues for potential treatments or preventive measures against NK-induced urothelial damage.
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- Inorganic arsenic (As) is a global pollutant linked to neurodegenerative disorders, with the study focusing on how it affects neuronal cells through autophagy and apoptosis.
- The research indicates that As exposure activates both autophagy and apoptosis in Neuro-2a cells, showing signs of cell death and increased autophagic markers, while inhibiting autophagy can prevent these effects.
- The study highlights that As-induced neuronal cell death is mediated by the inactivation of Akt and activation of AMPK, suggesting that targeting these pathways could help protect against arsenic-related neurotoxicity.
Human exposure to silica nanoparticles (SiNPs) has been widely applied as vehicles for drug delivery and cellular manipulations in nanoneuromedicine. SiNPs may cause adverse effects in the brain, but potential mechanisms underlying SiNPs-induced neurotoxicity are remained unclear. Here, we examined cytotoxic effects and the cellular mechanisms of SiNPs-induced neuronal cell death.
View Article and Find Full Text PDFPromotion of Bamboo Mosaic Virus Accumulation in Nicotiana benthamiana by 5'→3' Exonuclease NbXRN4.
Front Microbiol
January 2016
Bamboo mosaic virus (BaMV) has a 6.4-kb (+) sense RNA genome with a 5' cap and a 3' poly(A) tail. ORF1 of this potexvirus encodes a 155-kDa replication protein responsible for the viral RNA replication/transcription and 5' cap formation.
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