Skin Color Representation in Thyroid Textbooks: Lack of Imaging Diversity.

Introduction: Racial and ethnic disparities in the diagnosis and treatment of thyroid disease have been identified with various contributing factors, including delays in diagnosis and care, limited access to health care, and potential underlying provider bias. Individuals from racially and ethnically diverse backgrounds, particularly those with darker skin tones, have been historically underrepresented in medical textbooks; this underrepresentation contributes to the development of inherent racial biases in medical trainees when considering certain diagnoses. The potential impact that educational resources have on provider bias related to thyroid disease is limited.

Fourier-transform infrared spectroscopy for rapid serotyping in a tertiary care general hospital.

is the leading cause of community-acquired pneumonia and remains a significant contributor to bacteremia and meningitis, collectively known as invasive pneumococcal disease (IPD). Certain serotypes are more strongly associated with severe illness and antimicrobial resistance. Accurate serotyping is essential for effective IPD surveillance and vaccine development.

Pathogenic Aspergillus spp. and Candida spp. in coastal waters from southern Brazil: an one health approach.

Aspergillus and Candida are ubiquitous fungi included in the group of high priority in the World Health Organization list of fungal pathogens. They are found in various ecosystems and the environmental role in increasing the resistance to antifungals has been shown. Thus, we aimed to determine the occurrence of Aspergillus spp.

Pulmonary aspergillosis in green sea turtles (Chelonia mydas): A case series.

We report a series of invasive pulmonary aspergillosis in green turtles (Chelonia mydas) on the southern coast of Brazil. During 13-month period, seven animals were recovered on the coastal beach and sent to a rehabilitation center, dying after a period of captivity up to 27 days. Granulomatous nodules in the lung, with the presence of hyaline and septate hyphae, were found in all.

Interventions to improve symptomatology in patients with hypothyroidism and persistent symptoms: A systematic review.

Background: Levothyroxine (LT4) monotherapy is the standard treatment for hypothyroidism; however, 10-15% of patients have persistent hypothyroid symptoms despite normalizing thyroid hormone levels with LT4. This study aims to summarize the best available evidence on interventions to improve symptomatology in patients with hypothyroidism and persistent symptoms.

Methods: A systematic search was conducted in March 2022 for randomized controlled trials and observational studies on interventions for adult patients with persistent hypothyroid symptoms despite biochemical euthyroidism on thyroid hormone replacement.

Amlodipine and lufenuron as repurposing drugs against .

Background: Sporotrichosis caused by is a globally emerging infectious disease with limited therapeutic options. Thus, we aimed to evaluate the activity of amlodipine (AML) and lufenuron (LUF) alone and their interaction with itraconazole (ITZ), the first-choice drug against .

Methods: Twenty clinical isolates of from two hyperendemic regions were tested through a microdilution assay to evaluate the minimal inhibitory concentration (MIC) and minimal fungicidal concentration (MFC) of AML and LUF.

Real Practice Assessment of Persistent Symptoms After Initiation of Levothyroxine.

Objective: Levothyroxine (LT4) is the standard treatment for hypothyroidism. However, certain patients experience persistent symptoms even after achieving euthyroid status with LT4 therapy. We aimed to determine the frequency of persistent or new symptoms in patients with hypothyroidism after initiating LT4.

Does the duration of ambulatory consultations affect the quality of healthcare? A systematic review.

Background: The objective is to examine and synthesise the best available experimental evidence about the effect of ambulatory consultation duration on quality of healthcare.

Methods: We included experimental studies manipulating the length of outpatient clinical encounters between adult patients and clinicians (ie, therapists, pharmacists, nurses, physicians) to determine their effect on quality of care (ie, effectiveness, efficiency, timeliness, safety, equity, patient-centredness and patient satisfaction).

Information Sources: Using controlled vocabulary and keywords, without restriction by language or year of publication, we searched MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials and Database of Systematic Reviews and Scopus from inception until 15 May 2023.

Clinician feedback using a shared decision-making tool for the evaluation of patients with thyroid nodules-an observational study.

Background: We pilot-tested an encounter conversation aid to support shared decision making (SDM) between patients with thyroid nodules and their clinicians.

Objective: Characterize the clinician feedback after providing care to patients with thyroid nodules using a tool to promote SDM conversations during the clinical encounter, and evaluate how clinicians used the tool during the visit.

Methods: Mixed method study in two academic centers in the U.

Appropriateness of Levothyroxine Prescription: A Multicenter Retrospective Study.

Context: Levothyroxine is one of the most prescribed medications in the United States.

Objective: This study explores the appropriateness of levothyroxine prescriptions.

Methods: A retrospective multicenter study was conducted on adult patients who were prescribed levothyroxine for the first time between 2017 and 2020 at three academic centers in the United States.

Financial Toxicity in the Clinical Encounter: A Paired Survey of Patient and Clinician Perceptions.

Objective: To compare the agreement between patient and clinician perceptions of care-related financial issues.

Patients And Methods: We surveyed patient-clinician dyads immediately after an outpatient medical encounter between September 2019 and May 2021. They were asked to separately rate (1-10) patient's level of difficulty in paying medical bills and the importance of discussing cost issues with that patient during clinical encounters.

Patient feedback receiving care using a shared decision making tool for thyroid nodule evaluation-an observational study.

Purpose: To characterize the feedback of patients with thyroid nodules receiving care using a shared decision making (SDM) tool designed to improve conversations with their clinicians related to diagnostic options (e.g. thyroid biopsy, ultrasound surveillance).

Efficacy and Toxicity of Fexinidazole and Nifurtimox Plus Eflornithine in the Treatment of African Trypanosomiasis: A Systematic Review.

Human African trypanosomiasis (HAT), or sleeping sickness disease, is an infection caused mainly by human African trypanosomiasis (g-HAT) and is transmitted by tsetse flies. The disease goes through two stages: hemolymphatic and meningo-encephalic phases. The treatment for the second stage has changed from melarsoprol or eflornithine to nifurtimox-eflornithine combination therapy (NECT) and fexinidazole.

Usage of Direct Acting Oral Anticoagulants in Cirrhotic and Non-Cirrhotic Portal Vein Thrombosis: A Systematic Review.

Thrombosis of the portal vein (PVT) is generally seen in the setting of liver cirrhosis and to a lesser extent in the absence of cirrhosis. There is no clear guidance in relation to approaching treatment with anticoagulation in this condition. The professional societies and guidelines recommend treatment with traditional anticoagulation like low-molecular-weight heparin and vitamin-K antagonists in patients presenting with acute portal vein thrombosis.

Megalencephaly Polymicrogyria Polydactyly Hydrocephalus (MPPH): A Case Report and Review of Literature.

Megacephaly polymicrogyria, polydactyly, hydrocephalus (MPPH) is an extremely rare condition caused by a defect in the AKT3, CCND2, or PIKR2 genes. Although the prevalence of the syndrome is very low, there is a significant clinical and radiological variation in the syndrome. We present a case with MPPH admitted to the hospital due to an increase in seizure frequency.

Efficacy of Pitolisant on the Treatment of Narcolepsy: A Systematic Review.

Narcolepsy is characterized by excessive daytime sleepiness (EDS) and cataplexy. Histamine neurons play an important role in enhancing wakefulness. The objective of our study was to evaluate the efficacy of pitolisant, a histamine 3 (H3)-receptor antagonist/inverse agonist, in patients with a high burden of narcolepsy symptoms.

Chronic Liver Disease and the Risk of Osteoporotic Fractures: A Meta-Analysis.

Introduction Chronic liver disease (CLD) causes more than 1 million deaths every year and remains a pandemic in the last decade affecting more than 600,000 patients in the United States. Previous studies found patients with CLD had increased risk of osteoporosis, so fractures were inferred to be complications of this condition. The aim of this meta-analysis is to summarize the best evidence that correlates CLD patients and the risk to develop osteoporotic fractures versus control patients without CLD.

Celiac Disease and Risk of Atrial Fibrillation: A Meta-analysis and Systematic Review.

Introduction Several studies have found celiac disease may be associated with a variety of cardiac manifestations. Atrial fibrillation (AF) is one of the most common arrhythmias that can cause significant morbidity. However, the risk of atrial fibrillation in patients with celiac disease according to epidemiological studies remains unclear.

Inflammatory Bowel Disease and Risk of Osteoporotic Fractures: A Meta-Analysis.

Introduction Inflammatory bowel disease (IBD) and its complications have been well-established. The literature shows an association between IBD and decreased bone mineral density in the adult population. However, most studies have reported an association between IBD and osteoporosis, while the risk of fractures has not been well-studied.

Accessory gene regulator (Agr) functionality in Staphylococcus aureus derived from lower respiratory tract infections.

Objective: Characterization of Staphylococcus aureus clinical isolates derived from lower respiratory tract infections (LRTIs), and correlation between the functionality of the accessory gene regulator (Agr) and genotypic and phenotypic characteristics, clinical variables and clinical outcome.

Methods: S aureus isolates derived from LRTIs and control groups (nasal carriage and bacteraemia) were genotyped using StaphyType DNA microarray. Agr activity was evaluated using the CAMP synergistic haemolysis assay and the Vesicle Lysis Test (VLT).

Direct Identification of Urinary Tract Pathogens from Urine Samples, Combining Urine Screening Methods and Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry.

Early diagnosis of urinary tract infections (UTIs) is essential to avoid inadequate or unnecessary empirical antibiotic therapy. Microbiological confirmation takes 24 to 48 h. The use of screening methods, such as cytometry and automated microscopic analysis of urine sediment, allows the rapid prediction of negative samples.