Publications by authors named "Jeremy Gottlieb"
Generalized pustular psoriasis: a multicentric study on patient characteristics and clinical burden.
Orphanet J Rare Dis
February 2025
The objective of this study was to assess the demographic characteristics and impact on quality of life (QoL) of patients with PPG in France through a multicentre study. The results of the study are as follows: The PRO [PUSH-D, PHQ-9 et GAD-7] revealed that more than half of the patients exhibited a significant impact on their quality of life. High scores for fatigue, stress, skin and joint pain were reported, with 65% of patients at risk of mild to severe depression.
View Article and Find Full Text PDFAnti-SAE autoantibody in dermatomyositis: original comparative study and review of the literature.
Rheumatology (Oxford)
December 2023
Objective: Among specific autoantibodies in DM, the anti-small ubiquitin-like modifier activating enzyme (SAE) antibody is rare. We aim to describe the clinical characteristics, cancer prevalence, and muscle pathology of anti-SAE-positive DM.
Methods: Patients with a diagnosis of DM and sera positive for the anti-SAE antibody were recruited from 19 centres in this retrospective observational study.
Effectiveness and Safety of Adalimumab, Etanercept and Ustekinumab for Severe Psoriasis in Children Under 12 Years of Age: A French-Italian Daily Practice Cohort (BiPe Jr).
Paediatr Drugs
May 2022
Article Synopsis
- Biological therapies are effective for treating severe psoriasis in children under 12, but this age group is often not included in clinical trials.
- The 'BiPe Jr' study analyzed data from 82 children in France and Italy who received biological treatments, showcasing significant improvement in psoriasis severity and treatment duration for drugs like adalimumab and ustekinumab.
- Although 52 children stopped their treatments mostly due to ineffectiveness and remission, the study pointed out safety concerns with reports of serious adverse events, including severe infections.
In the context of the current coronavirus disease 2019 (COVID-19) pandemic, cutaneous lesions are being described. Here, we report on a 13-year-old girl with SARS-CoV-2-associated Henoch-Schönlein purpura and Epstein-Barr virus (EBV) infection. She presented without any respiratory symptoms, only a purpuric skin rash, abdominal pain, low-grade fever, and pharyngitis.
View Article and Find Full Text PDFEffectiveness and Safety of Anti-interleukin-17 Therapies in Elderly Patients with Psoriasis.
Acta Derm Venereol
November 2020
Anti-interleukin-17 agents have recently been developed for the treatment of psoriasis. This study evaluated the tolerance and effectiveness of anti-interleukin-17 agents for psoriasis in elderly patients in daily practice. A multicentre, retrospective study was performed, involving psoriatic patients aged ≥65 years who had received an anti-interleukin-17 agent, including secukinumab, ixekizumab or brodalumab.
View Article and Find Full Text PDFF-FDG PET/CT of sarcoidosis with extensive cutaneous and subcutaneous nodules: the snow leopard sign.
Eur J Nucl Med Mol Imaging
August 2019
Background: Paraneoplastic pemphigus (PNP) occurs more often in patients with hematologic malignancies (HMs) than in patients with solid cancer. Lung bronchiolitis obliterans (BO) is a severe complication of PNP.
Objective: To determine the precise clinical and biologic features of HM-associated PNP and identify factors associated with mortality and survival.
Osteopenia and fractures associated with long-term therapy with MEK inhibitors.
Melanoma Res
December 2018
Article Synopsis
- Targeted therapies for melanoma, specifically MEK inhibitors and BRAF/MEK combinations, have improved patient survival but may lead to adverse side effects like osteopenia.
- Two patients with advanced melanoma developed fractures due to severe osteopenia after long-term treatment, despite having no typical risk factors for osteoporosis.
- The study suggests that MEK inhibitors could be linked to the development of osteopenia, highlighting the need for further investigation into their long-term effects on bone health and patient quality of life.
Article Synopsis
- Cutaneous squamous cell carcinoma (cSSC) is a prevalent skin cancer that poses a serious risk, including death, making early detection of lymph node metastasis essential.
- The study aimed to assess the effectiveness of sentinel lymph node biopsy (SLNB) in predicting patient outcomes for cSSC by analyzing 37 patients from a hospital and 290 cases from previous literature.
- Results showed that while the rate of positive SLNB was low (0.14), it did not significantly influence relapse-free survival or overall survival, indicating that SLNB may not be essential for managing cSSC.
Article Synopsis
- Advances in targeted therapy and immune checkpoint inhibitors, like cobimetinib and vemurafenib, have improved the prognosis for melanoma patients, particularly those with BRAF mutations.
- A case study highlighted a serious side effect of cobimetinib: focal necrotizing myopathy with symptoms such as severe neck weakness and elevated creatine phosphokinase (CPK) levels, confirmed by muscle biopsy.
- After temporarily stopping cobimetinib and normalizing CPK levels, the patient showed a partial response, leading to a continued but reduced dosage of the therapy, emphasizing the importance of being aware of potential adverse effects in future treatments.
Autoimmune diabetes induced by PD-1 inhibitor-retrospective analysis and pathogenesis: a case report and literature review.
Cancer Immunol Immunother
November 2017
Article Synopsis
- Anti-PD-1 antibody treatment is effective for advanced melanoma, improving survival rates but comes with significant immune-related side effects like rash and thyroiditis.
- A case study highlighted a 73-year-old man who developed autoimmune diabetes following nivolumab treatment, leading to diabetic ketoacidosis six weeks in.
- Investigations showed pre-existing islet cell autoantibodies, indicating a potential autoimmune reaction triggered by the medication, suggesting that glucose levels should be closely monitored in patients on PD-1 blockade.