Publications by authors named "Jeanne de La Rochefoucauld"
TNF-alpha blockade in primary chronic non-bacterial osteomyelitis of the mandible.
Rheumatology (Oxford)
April 2025
Article Synopsis
- Primary chronic Non-Bacterial Osteomyelitis of the jaw is a rare inflammatory disease that shares similarities with SAPHO syndrome and chronic recurrent multifocal osteomyelitis, and TNF-alpha blockade may be an effective treatment option despite limited clinical data.
- In a study of 15 patients with refractory CNOM, 10 were treated with anti-TNF-alpha therapy due to previous treatment failures and the promising efficacy seen in related conditions.
- The results showed that most patients experienced rapid and lasting remission without serious side effects, though male patients appeared to have poorer outcomes, indicating that TNF-alpha blockade is both safe and effective for CNOM management.
Secondary haemophagocytic lymphohistiocytosis (sHLH) proceeds from uncontrolled and inefficient immune activation leading to hyper-inflammation and multi-organ damage. sHLH proceeds from a wide panel of infectious, auto immune and malignant conditions and bears high mortality despite treatment. Literature on sHLH does not mention heart involvement.
View Article and Find Full Text PDFImmune checkpoint inhibitors (ICIs) have revolutionized cancer treatment. The number of indications is increasing and antibodies targeting the CTLA-4 and PD-1/PD-L1 pathways are now also prescribed in adjuvant settings and for metastatic cancer. However, ICIs reactivate autoreactive immune cells as well as tumour-specific T cells, which lead to immune-related adverse events (irAEs) in around 70% of treated patients.
View Article and Find Full Text PDF