Encouraging collagen and epithelial layer formation via poly (lactic acid)/hyaluronic acid hybrid wound dressing containing niacinamide.

This study examines the fabrication and characterization of electrospun nanofibrous mats composed of poly (lactic acid) (PLA), hybridized hyaluronic acid (HA), and niacinamide (NA) for potential applications in wound dressings. PLA and HA concentrations were changed from 4 to 12 wt% and 0.25 to 1 wt%, respectively.

Employing Polymer and Gel to Fabricate Scaffold-like Cancellous Orthopedic Screw: Polycaprolactone/Chitosan/Hydroxyapatite.

Using metallic/polymeric orthopedic screws causes cavities in bone trauma after the attachment of broken bones, which prolongs the healing. Yet, it remains unknown how to overcome such a challenge. The main aim of this research was to use both polymers and gels to fabricate and study a new PCL/chitosan/hydroxyapatite scaffold-like orthopedic screw for cancellous bone trauma.

Janus Films Wound Dressing Comprising Electrospun Gelatin/PCL Nanofibers and Gelatin/Honey/Curcumin Thawed Layer.

A promising approach for wound treatment is using multilayer wound dressings that offer multifunctional properties. In this study, a bilayered electrospun/hydrogel gelatin-based scaffold integrated with honey and curcumin was developed to treat wounds under an in vivo study. The first layer consisted of an enzymatic cross-linked gelatin hydrogel containing honey and curcumin, which gelatin/PCL nanofibers reinforced.

A response surface methodology study on the development of pH-sensitive wound dressings using Rhodamine B-loaded chitosan nanoparticles and sodium alginate-based films.

Purpose: This study aimed to develop an innovative, intelligent wound dressing capable of signaling infections through color changes.

Design/methodology/approach: Using response surface methodology, the Rhodamine B fluorescence colorant was encapsulated within colloidal nanoparticles and integrated into a sodium alginate patch at various concentrations. The physical and chemical characteristics of the nanoparticles and the wound dressing were thoroughly analyzed via dynamic light scattering (DLS), zeta potential measurements, scanning electron microscopy (SEM), and Fourier transform infrared spectroscopy (FTIR).

Fabrication and Evaluation of a Soy Protein Isolate/Collagen/Sodium Alginate Multifunctional Bilayered Wound Dressing: Release of Cinnamaldehyde, Artemisia absinthium, and Oxygen.

Chronic wounds, such as diabetic ulcers and pressure sores, pose significant challenges in modern healthcare due to their prolonged healing times and susceptibility to infections. This study aims to engineer a bilayered wound dressing (BLWD) composed of soy protein isolate/collagen with the ability to release Cinnamaldehyde, (AA), and oxygen. Cinnamaldehyde, magnesium peroxide (MgO), and AA extract were encapsulated.

Development and characterization of Polycaprolactone/chitosan-based scaffolds for tissue engineering of various organs: A review.

Research in creating 3D structures mirroring the extracellular matrix (ECM) with accurate environmental cues holds paramount significance in biological applications.Biomaterials that replicate ECM properties-mechanical, physicochemical, and biological-emerge as pivotal tools in mimicking ECM behavior.Incorporating synthetic and natural biomaterials is widely used to produce scaffolds suitable for the intended organs.

Simultaneous usage of sulforaphane nanoemulsion and tannic acid in ternary chitosan/gelatin/PEG hydrogel for knee cartilage tissue engineering: In vitro and in vivo study.

The therapeutic potential of tissue engineering in addressing articular cartilage defects has been a focal point of research for numerous years. Despite its promising outlook, a persistent challenge within this domain is the lack of sufficient functional integration between engineered and natural tissues. This study introduces a novel approach that employs a combination of sulforaphane (SFN) nanoemulsion and tannic acid to enhance cartilage tissue engineering and promote tissue integration in a rat knee cartilage defect model.

In Vitro Release of Glycyrrhiza Glabra Extract by a Gel-Based Microneedle Patch for Psoriasis Treatment.

Microneedle patches are attractive drug delivery systems that give hope for treating skin disorders. In this study, to first fabricate a chitosan-based low-cost microneedle patch (MNP) using a CO laser cutter for in vitro purposes was tried and then the delivery and impact of Glycyrrhiza glabra extract (GgE) on the cell population by this microneedle was evaluated. Microscopic analysis, swelling, penetration, degradation, biocompatibility, and drug delivery were carried out to assess the patch's performance.

A review about the role of additives in nerve tissue engineering: growth factors, vitamins, and drugs.

Notably the integration of additives such as growth factors, vitamins, and drugs with scaffolds promoted nerve tissue engineering. This study tried to provide a concise review of all these additives that facilitates nerve regeneration. An attempt was first made to provide information on the main principle of nerve tissue engineering, and then to shed light on the effectiveness of these additives on nerve tissue engineering.

Reliable Kinetics for Drug Delivery with a Microfluidic Device Integrated with the Dialysis Bag.

The clinical success of a drug delivery system turns back to performing experiments with more reliable data. The dialysis bag has been one of the most employed technologies to monitor drug release from nanocarriers, membranes, and scaffolds. Unfortunately, this technology has several challenges regarding the accuracy of the obtained results.

Discussing the final size and shape of the reconstructed tissues in tissue engineering.

Tissue engineering (TE) has made a revolution in repairing, replacing, or regenerating tissues or organs, but it has still a long way ahead. The mechanical properties along with suitable physicochemical and biological characteristics are the initial criteria for scaffolds in TE that should be fulfilled. This research will provide another point of view toward TE challenges concerning the morphological and geometrical aspects of the reconstructed tissue and which parameters may affect it.

Tannic Acid as a Green Cross-linker for Biomaterial Applications.

Plant-derived tannic acid as a green material can play an important role in improving the mechanical and physical properties of biomaterials. Tannic acid can be used as an antioxidant, antimicrobial, and cross-linking agent in biomaterial products due to its unique functional groups. Its active phenolic groups can react with biomaterial functional groups to form bonds that improve performance.

3D printed chitosan/polycaprolactone scaffold for lung tissue engineering: hope to be useful for COVID-19 studies.

To prevent or reduce mortality from lung diseases, new biological materials and scaffolds are needed to conduct more accurate research and support lung tissue regeneration. On the other hand, the outbreak of the COVID-19 virus and its targeting of the human lung has caused many deaths worldwide. The main aim of this study was to provide a biologically and mechanically suitable 3D printed scaffold using chitosan/polycaprolactone bioink for lung tissue engineering.

Employing hydrogels in tissue engineering approaches to boost conventional cancer-based research and therapies.

Cancer is a complicated disease that involves the efforts of researchers to introduce and investigate novel successful treatments. Traditional cancer therapy approaches, especially chemotherapy, are prone to possible systemic side effects, such as the dysfunction of liver or kidney, neurological side effects and a decrease of bone marrow activity. Hydrogels, along with tissue engineering techniques, provide tremendous potential for scientists to overcome these issues through the release of drugs at the site of tumor.

Decellularized Alstroemeria flower stem modified with chitosan for tissue engineering purposes: A cellulose/chitosan scaffold.

Utilizing plant-based scaffolds has pulled in the consideration of tissue engineers. Plant tissues own different structures with particular porosity and structure. In this study, the stem of the Alstroemeria flower was designated for decellularization to fabricate a new scaffold.

Integration of microbubbles with biomaterials in tissue engineering for pharmaceutical purposes.

Tissue engineering with the aid of biomaterials is a novel and promising knowledge aiming at improving human life expectancy. Besides, microbubbles are increasingly employed in biomedical applications due to their capability as a reservoir of therapeutic agents and oxygen molecules. In the present study, Microbubbles as the backbone of the research are produced as one of the potent devices in tissue engineering approaches, including drug delivery, wound healing, 3D printing, and scaffolding.

Comparison of muscle synergies extracted from both legs during cycling at different mechanical conditions.

Muscle synergies are the building blocks for generating movement by the central nervous system (CNS). According to this hypothesis, CNS decreases the complexity of motor control by combination of a small number of muscle synergies. The aim of this work is to investigate similarity of muscle synergies during cycling across various mechanical conditions.

Practical stabilization of time-delay fractional-order systems by parametric controllers.

This paper stabilization of time-delayed fractional-order systems by unlimited controllers is considered. To achieve the best controller so that the system be stable, the parameters of the feedback matrices are determinate with the minimum norm. Various constraints applied by the designer to obtain the desired performance criteria.