Association of left atrial strain and fibrin clot properties in patients with heart failure and severe mitral regurgitation undergoing transcatheter edge-to-edge repair.

The link between heart failure (HF) and increased prothrombotic risk has gathered attention, with several studies exploring this association. Patients with HF and severe mitral regurgitation (MR) undergoing transcatheter edge-to-edge repair (TEER) may present enhanced left atrial (LA) function and improve thrombosis-related factors due to the procedure. This study investigates the role of left atrial strain (LAS), assessed via speckle-tracking echocardiography, in detecting subtle LA abnormalities and its potential link to thrombotic risk in severe MR patients.

Short- and mid-term outcomes in patients undergoing transcatheter aortic valve implantation in Poland in 2019-2023.

Background: Transcatheter aortic valve implantation (TAVI) has become a cornerstone in the treatment of severe aortic stenosis, with expanding indications for lower-risk patients. However, real-world data, especially regarding post-discharge outcomes, from multicenter registries are scarce but needed.

Aims: To evaluate the in-hospital and mid-term outcomes of patients undergoing TAVI in all Polish centers between 2019 and 2023.

The impact of transcatheter aortic valve implantation (TAVI) on mitral regurgitation - a single center study.

Background: The coexistence of mitral regurgitation (MR) and severe aortic stenosis (AS) has been associated with worse outcomes in patients undergoing transcatheter aortic valve implantation (TAVI). Herein, the aim was to assess the etiology and degree of MR in an unselected TAVI population and investigate the impact of MR reduction at mid-term follow-up.

Methods: Patients subjected to TAVI as a treatment for severe AS in a single center were retrospectively analyzed.

Thrombin generation, fibrin clot permeation and lysis in patients with severe mitral regurgitation undergoing transcatheter edge-to-edge mitral valve repair: Mitral Fibrin Study.

Introduction: Intricate management of heart failure (HF), especially in the context of reduced ejection fraction, is further complicated by an elevated risk of thromboembolic events. Studies published so far offer inconclusive insight into the interplay between mitral regurgitation (MR) and the coagulation system.

Objectives: This study aimed to investigate the impact of transcatheter edge‑to‑edge repair (TEER) on specific coagulation parameters in HF patients.

Apolipoprotein A1 Infusions and Cardiovascular Outcomes after Acute Myocardial Infarction.

Background: Cardiovascular events frequently recur after acute myocardial infarction, and low cholesterol efflux - a process mediated by apolipoprotein A1, which is the main protein in high-density lipoprotein - has been associated with an increased risk of cardiovascular events. CSL112 is human apolipoprotein A1 derived from plasma that increases cholesterol efflux capacity. Whether infusions of CSL112 can reduce the risk of recurrent cardiovascular events after acute myocardial infarction is unclear.