Association between acute kidney injury, delirium and outcomes in patients with critical illness: a protocol for a systematic review.

Introduction: Acute kidney injury (AKI) and delirium are common clinical complications of critical illness. Relatively few studies have evaluated the relationship between AKI and delirium. This systematic review will assess this association among critically ill patients.

Sex and gender considerations in randomized controlled trials in critical care nephrology: a meta-epidemiologic study.

Background: How sex and gender are considered in randomized controlled trials (RCTs) in critical care nephrology is unclear. We aimed to perform a meta-epidemiologic study to describe the representation, sex and gender reporting, and sex- and gender-based analyses (SGBA) in high-impact RCTs in critical care nephrology.

Methods: We searched the Web of Science Core Collection for critical care nephrology papers from 2000 to 2024.

Understanding preconception care: a scoping review of knowledge, attitudes and practices among reproductive age individuals, healthcare workers and stakeholders in low- and middle-income countries.

Objectives: This scoping review aims to map existing evidence on knowledge, attitudes and practices (KAP) and barriers to preconception care in low- and middle-income countries. The primary objective is to identify key gaps and research priorities to guide future efforts to improve maternal and child health.

Design: This review followed Arksey and O'Malley's scoping review framework, with a comprehensive search across Medline, EMBASE, CINAHL and Scopus from inception to May 2025.

Global prevalence of chronic kidney disease and associated risk factors in children and adolescents: protocol for a systematic review and meta-analysis.

Introduction: While chronic kidney disease (CKD) is well characterised in adults, less is known about the prevalence of CKD in children and adolescents, where it is rare and associated with unique characteristics and implications for long-term health outcomes. This study protocol outlines a systematic review to assess the global prevalence of CKD in children and adolescents along with causes and associated risk factors. This is warranted to better characterise prevalence and to identify at-risk groups that would benefit from screening efforts.

Gastroesophageal reflux disease after biliopancreatic diversion-duodenal switch: a systematic review and meta-analysis.

Introduction: Biliopancreatic diversion-duodenal switch (BPD-DS) procedures are being performed more often for patients with higher metabolic burden. These patients routinely get a concomitant sleeve gastrectomy. However, the effect on postoperative GERD has not been clearly elucidated.

Nursing regulation in Canada: Insights from a scoping review.

Canadian nursing regulators have implemented various innovations to reform regulatory approaches to address workforce challenges, system demands, governance reforms, and a drive for efficiency. Given the significant role that regulators play in influencing patient safety, workforce, and health system outcomes, decision-making must be evidence-informed. This review examined the nature, extent, and range of literature related to nursing regulation in Canada and how the existing scholarship aligns with emerging regulatory and health system trends to inform the development of a research agenda.

Augmented intelligence in oral and maxillofacial radiology: a systematic review.

Background: Artificial intelligence (AI) is transforming diagnostic imaging in dentistry. This systematic review evaluates existing literature on augmented intelligence in dentomaxillofacial radiology, focusing on its influence on human collaboration in interpreting dental imaging.

Study Design: A literature search across seven databases and gray literature was conducted.

Health-related stigma among Indigenous Peoples in Canada: A scoping review.

Background: Indigenous communities in Canada are disproportionately affected by health conditions linked to stigma, warranting the attention of researchers seeking to understand this culturally-determined phenomenon. This study explores the scope of research on health-related stigma conducted with the First Nations, Inuit, and Métis Peoples.

Method: We conducted a scoping review using the method described by Arksey and O'Malley.

Key performance indicators for acute intermittent kidney replacement therapy in critically ill patients: a protocol for a systematic review.

Introduction: There have been previous initiatives to identify key performance indicators (KPIs) for continuous kidney replacement therapy. However, no formal reviews of the evidence for KPIs of intermittent kidney replacement therapy (IKRT) have been conducted. This systematic review will appraise the evidence for KPIs of IKRT in critically ill patients and is part of the DIALYZING WISELY (NCT05186636) programme which aims to improve the performance of acute renal replacement therapy in intensive care units by aligning local practices with evidence-based best practices.

Impact of myofunctional therapy on orthodontic management and orthognathic surgery outcomes: a scoping review.

Background: Orofacial myofunctional disorders (OMDs) are conditions or behaviors that negatively affect oral postures and functions. These behaviors can interfere with normal orofacial growth and development and related functions.

Objectives: Map the available evidence regarding the effectiveness of Orofacial Myofunctional Therapy (OMT) in treating or managing OMDs associated with specific malocclusion traits or orthognathic surgery outcomes.

Beyond Depression: The Role of Antidepressants in Managing Chronic Temporomandibular Disorders. A Systematic Review.

Background: Chronic temporomandibular disorder (TMD) pain significantly impairs quality of life and lacks universally effective treatments. Antidepressants, traditionally used for mood disorders, have shown potential in managing chronic pain conditions. This systematic review evaluates the efficacy and safety of antidepressants for chronic TMD pain management.

Effectiveness of orofacial myofunctional therapy in improving orofacial function and oral habits: a scoping review.

Background: The effectiveness of orofacial myofunctional therapy (OMT) has yet to be confirmed in the literature. This scoping review aimed to answer the question, "What evidence exists to support the effectiveness of OMT in treating/managing orofacial myofunctional disorders (OMDs) affecting orofacial structures' function and oral habits?"

Methods: A librarian at the University of Alberta, Canada, developed a comprehensive search strategy and applied it to 6 databases and grey literature. The reference lists of included studies were cross-checked.

Implementation of harm reduction services for people who use drugs provided by pharmacy staff: a scoping review protocol.

Introduction: The disparities and risk trajectories experienced by people who use drugs (PWUD) highlight the critical need for equity-oriented strategies. Pharmacy staff (pharmacists, pharmacy technicians and assistants) make essential contributions to public health, and their role in the response to the drug overdose crisis can be understood as an extension of their public health role. Their involvement in overdose prevention strategies, such as take-home naloxone programmes and prescribed opioid medication management, has been documented.

Performance measurement and evaluation of health practitioner regulation: A scoping review protocol.

Health practitioner regulation plays a fundamental role in public protection by overseeing and governing healthcare professionals to ensure they deliver safe health services. It also serves as a strategic lever to strengthen broader health system goals such as improving the accessibility of services, the sustainability of health workforces, and health system resilience. Although the goals of health practitioner regulation are easily articulated, achieving and evaluating these goals are far more challenging.

Addressing the mental health needs of healthcare professionals in Africa: a scoping review of workplace interventions.

Healthcare workers in Africa face considerable stress due to factors like long working hours, heavy workloads and limited resources, leading to psychological distress. Generally, countries in the global north have well-established policies and employee wellness programs for mental health compared to countries in the global south. This scoping review aimed to synthesize evidence from published and grey literature on workplace mental health promotion interventions targeting African healthcare workers using Social Ecological Model (SEM) and the Job Demands-Resources (JD-R) model as an underlying theoretical framework for analysis.

Indigenous Peoples Living with Multiple Sclerosis in Canada.

Indigenous Peoples in Canada are comprised of First Nations, Inuit and Métis and are the youngest and fastest growing population in the country. However, there is limited knowledge of how they are affected by multiple sclerosis (MS), the most common nontraumatic neurological disease of young adults, with Canada having one of the highest prevalences in the world. In this narrative review, we outline the limited studies conducted with Indigenous Peoples living with MS in Canada and the gaps in the literature.

Liveborn children with trisomy 18: A scoping review.

Background: There have been an increasing number of publications related to trisomy 18 associated with a shift in the philosophy of care. The objective of this review is to understand the scope of contemporary literature informing the care of children born alive with trisomy 18.

Methods: Included was peer-reviewed, primary literature in MEDLINE, Embase, CINAHL, Scopus, Web of Science, and Cochrane Library from 2012 to 2023 reporting outcomes of children born alive with trisomy 18.

The Impact of Augmented Renal Clearance on the Pharmacokinetics of Levetiracetam in Critically Ill Patients: A Literature Review.

Levetiracetam is an antiseizure medication (ASM) that has several advantages over other ASMs, such as dose-proportional pharmacokinetics, high bioavailability, and minimal drug interactions. The drug is primarily eliminated through the kidneys. Therefore, dose adjustments are necessary in patients with renal impairment or patients experiencing augmented renal clearance (ARC) to maintain optimal efficacy and safety.

Liver Allograft Cirrhosis, Retransplant, and Mortality Secondary to Recurrent Disease After Transplant for MASH: A Systematic Review and Meta-analysis.

Background: Recurrent disease after liver transplant is well recognized for many diseases. Metabolic dysfunction-associated steatotic liver disease (MASLD) and steatohepatitis (MASH) are leading indications for liver transplant, and there is scarce knowledge about recurrence-related end outcomes such as retransplant and mortality. This project aims to assess the proportion of patients transplanted for MASH who develop recurrent disease and adverse clinical outcomes.

Role of prolonged packing in postoperative anorectal abscess management: a systematic review and meta-analysis.

Background: Prolonged packing of anorectal abscess cavities with internal dressings after incision and drainage is frequently used, but the efficacy of this practice remains controversial. Some studies highlight its use in hemostasis and preventing fistula and abscess recurrence, whereas others describe its economic burden and increase in pain. In this systematic review, we examine current evidence on the impact of packing after incision and drainage for anorectal abscesses.

Do beta-amyloid-targeted interventions improve cognition, physical functioning, and overt behaviour of Alzheimer's Disease (AD) patients: Protocol for meta-analysis of Phase 3 clinical trials both completed and terminated.

Accumulation of amyloid-beta (Aβ) in the brain has been explored as a primary cause of Alzheimer's Disease (AD). Better known as the amyloid hypothesis, it has been the main target of researchers vying to bring their therapeutic interventions to market despite several failed attempts by predecessors. In June 2021, Aduhelm (Aducanumab) became the first U.