Practice of oxygenation and respiratory support during fibreoptic bronchoscopy: the OxyFOB study protocol.

Introduction: Flexible bronchoscopy (FB) is widely used for diagnostic and therapeutic procedures in pulmonary medicine. However, FB can cause respiratory and haemodynamic complications, especially in patients with pre-existing lung and/or cardiovascular comorbidities. Despite the range of oxygenation and ventilatory approaches available to prevent these risks, evidence regarding their real-world application and clinical impact is limited.

Effects of azithromycin in severe eosinophilic asthma with concomitant monoclonal antibody treatment.

Macrolides reduce exacerbations when added to inhaled therapy in severe asthma. However, there is little published evidence for effectiveness in patients treated with biologics. We conducted a retrospective audit of all patients who started azithromycin while on biologics in our centre.

Treating eosinophilic exacerbations of asthma and COPD with benralizumab (ABRA): a double-blind, double-dummy, active placebo-controlled randomised trial.

Background: Exacerbations of asthma and chronic obstructive pulmonary disease (COPD) are important events and are associated with critical illness. Eosinophilic inflammation is a treatable trait commonly found during acute exacerbations of asthma and COPD. We hypothesised that for patients with eosinophilic exacerbations, a single injection of benralizumab, a humanised monoclonal antibody against interleukin-5 receptor-α, alone or in combination with prednisolone, will improve clinical outcomes compared with prednisolone, the standard of care.

Type 2 severe asthma: pathophysiology and treatment with biologics.

Introduction: The hallmark of most patients with severe asthma is type 2 inflammation, driven by innate and adaptive immune responses leading to either allergic or non-allergic eosinophilic infiltration of airways. The cellular and molecular pathways underlying severe type 2 asthma can be successfully targeted by specific monoclonal antibodies.

Areas Covered: This review article provides a concise overview of the pathophysiology of type 2 asthma, followed by an updated appraisal of the mechanisms of action and therapeutic efficacy of currently available biologic treatments used for management of severe type 2 asthma.

Recovery of Breakthrough Asthma Attacks Treated With Oral Steroids While on Monoclonal Antibody Therapy: Protocol for a Prospective Observational Study (BOOST).

Background: Asthma attacks are a common and important problem. Someone experiences an asthma attack in the United Kingdom every 10 seconds. Asthma attacks cause coughing, wheezing, breathlessness, and chest tightness and are highly stressful for patients.

Persistence of inflammatory and vascular mediators 5 months after hospitalization with COVID-19 infection.

Background And Aim: In acute severe COVID-19, patients present with lung inflammation and vascular injury, accompanied by an exaggerated cytokine response. In this study, our aim was to describe the inflammatory and vascular mediator profiles in patients who were previously hospitalized with COVID-19 pneumonitis, months after their recovery, and compare them with those in patients recovering from severe sepsis and in healthy controls.

Methods: A total of 27 different cytokine, chemokine, vascular endothelial injury and angiogenic mediators were measured in the plasma of forty-nine patients 5.

Take a Deep Breath - Time to Plunge into Inducible Laryngeal Obstruction.

Inducible laryngeal obstruction (ILO)/vocal cord dysfunction is frequently encountered in the specialist asthma clinic, where it is often misdiagnosed as asthma or is coexistent with asthma. It causes recurrent distressing episodes of acute dyspnea that can lead to hospital admissions, endotracheal intubation, and fruitless asthma treatment escalation, often including oral glucocorticoids. Early diagnosis and treatment of ILO offers the prospect of connecting patients with an effective speech- and language-based intervention earlier and avoiding these unnecessary and potentially harmful interventions.

Should we apply a treatable traits approach to asthma care?

Objective: To explore the evidence for adopting a "treatable traits" approach to asthma management.

Data Sources: PubMed, Medline, and Google Scholar.

Study Selections: The above-mentioned databases were searched for randomized, controlled phase III or IV trials of adults containing the word "asthma" in the title published in the previous 10 years and for all articles containing the title words "treatable AND trait(s)," "asthma AND biomarker(s) OR smoking OR obesity OR laryngeal OR management" published within the previous 5 years.

Pneumomediastinum in COVID-19: a phenotype of severe COVID-19 pneumonitis? The results of the UK POETIC survey.

Background: There is an emerging understanding that coronavirus disease 2019 (COVID-19) is associated with increased incidence of pneumomediastinum (PTM). We aimed to determine its incidence among patients hospitalised with COVID-19 in the UK and describe factors associated with outcome.

Methods: A structured survey of PTM and its incidence was conducted from September 2020 to February 2021.

Derivation of a prototype asthma attack risk scale centred on blood eosinophils and exhaled nitric oxide.

Reduction of the risk of asthma attacks is a major goal of current asthma management. We propose to derive a risk scale predicting asthma attacks based on the blood eosinophil count and exhaled nitric oxide (FeNO). Biomarker-stratified trial-level attack rates were extracted and pooled from the control arms of the Novel START, CAPTAIN, QUEST, Benralizumab Phase 2b, PATHWAY, STRATOS 1-2 and DREAM trials (n=3051).

A multi-centre open-label two-arm randomised superiority clinical trial of azithromycin versus usual care in ambulatory COVID-19: study protocol for the ATOMIC2 trial.

Background: Azithromycin is an orally active synthetic macrolide antibiotic with a wide range of anti-bacterial, anti-inflammatory and antiviral properties. It is a safe, inexpensive, generic licenced drug available worldwide and manufactured to scale and is a potential candidate therapy for pandemic coronavirus disease 2019 (COVID-19). Azithromycin was widely used to treat severe SARS-CoV and MERS-CoV, but to date, no randomised data are available in any coronavirus infections.

Segmentation by lexical subtraction in Hungarian speakers of second-language English.

Using cross-modal form priming, we compared the use of stress and lexicality in the segmentation of spoken English by native English speakers (L1) and by native Hungarian speakers of second-language English (L2). For both language groups, lexicality was found to be an effective segmentation cue. That is, spoken disyllabic word fragments were stronger primes in a subsequent visual word recognition task when preceded by meaningful words than when preceded by nonwords: For example, the first two syllables of corridor were a more effective prime for visually presented corridor when heard in the phrase anythingcorri than in imoshingcorri.

Effects of syntactic expectations on speech segmentation.

Although the effect of acoustic cues on speech segmentation has been extensively investigated, the role of higher order information (e.g., syntax) has received less attention.

Sentential, lexical, and acoustic effects on the perception of word boundaries.

This study investigates the effects of sentential context, lexical knowledge, and acoustic cues on the segmentation of connected speech. Listeners heard near-homophonous phrases (e.g.

Detecting silent pauses in speech: a new tool for measuring on-line lexical and semantic processing.

In this study, we introduce pause detection (PD) as a new tool for studying the on-line integration of lexical and semantic information during speech comprehension. When listeners were asked to detect 200-ms pauses inserted into the last words of spoken sentences, their detection latencies were influenced by the lexical-semantic information provided by the sentences. Listeners took longer to detect a pause when it was inserted within a word that had multiple potential endings, rather than a unique ending, in the context of the sentence.