Association Between Healing Hurt People Hospital-Based Violence Intervention Program Participation and Trauma-Related Psychological Symptoms for Violent Injury Survivors.

Objectives: Examine associations between engagement with the hospital-based violence intervention program, Healing Hurt People (HHP), and trauma-related psychological symptoms among violently injured people ages 18 to 30 years.

Methods: Participants selected from 3 hospitals' emergency departments (EDs) completed clinical scales for posttraumatic stress disorder (PTSD) with the PTSD Checklist for DSM-5 (PCL-5), depression with the Patient Health Questionnaire -8 (PHQ-8), sleep with the Patient-Reported Outcomes Measurement Information System (PROMIS), and perceived stress with the perceived stress scale at baseline (≤90 days after presenting to ED) and follow-up (intended follow-up 6 months after baseline). Controls were selected from the EDs of 2 hospitals before the launch of HHP between 2015 and 2016.

A Comprehensive Analysis of Socio-economic and Clinical Factors in Head and Neck Cancer Patients Receiving Robotic Surgery.

Objectives: To investigate socio-economic and clinical disparities in the utilisation of robotic surgery for head and neck cancer.

Methods: Using the National Cancer Database (2010-2020), 212 449 surgically treated patients were analysed. Multivariate logistic regression identified predictors of robotic versus non-robotic surgery ( < 0.

Transient Dietary Changes Modulate Inflammatory Disease Trajectory in the Lean State.

Obesity potently alters immune responses across various inflammatory contexts . However, it is unclear whether a transient high-fat diet (HFD) can affect immune function despite minimal effects on body weight. Here, we demonstrate that a short-term HFD regimen significantly exacerbates disease severity in a model of experimental psoriasis, comparable to what is observed in obese mice on long-term HFD.

A Systematic Review of Case Reports of Spontaneous Retropharyngeal Hematoma.

Objective: Spontaneous retropharyngeal hematoma (SRH) is a rare and potentially life-threatening condition with the potential to cause acute airway obstruction. This review aims to describe the presentation, predisposing factors, and management of SRH cases to better understand the clinical course and guide strategies for identifying and managing this condition.

Data Sources: PubMed, Embase, and Web of Science.

Augmenting Parenting Programs With the Pause Mobile App: Mixed Methods Evaluation.

Background: Parenting programs are the recommended treatment for common mental health problems of childhood such as conduct disorder. In the United Kingdom, local authorities have responsibility for providing or commissioning these programs through face-to-face and video call weekly groups and e-learning style asynchronous offerings. However, there has been a shortage of research into the potential of digital resources to augment and enhance parenting groups.

Scalable Fabrication of Perovskite Solar Cells with Inkjet-Printed Perovskite Absorbers Processed under Ambient Conditions.

It is still a challenge to fabricate a smooth, high-quality perovskite film under ambient conditions via an inkjet printing process. Here, we report a systematic study of the fabrication of one-step inkjet-printed metal halide perovskite (IJP-MHP) films under ambient conditions. An inkjet-printed perovskite film with full surface coverage and large columnar grains was obtained through in situ heat treatment, self-vapor annealing (self-VA), and solvent engineering.

RORγt eTACs mediate oral tolerance and Treg induction.

The immune system must distinguish pathogens from innocuous dietary antigens, but the precise mechanisms and cellular actors remain unclear. Here, we demonstrate that RORγt-lineage APCs are required for oral tolerance. Using lineage tracing and single-cell sequencing, we show these APCs consist of three principal populations: type 3 innate lymphoid cells (ILC3s), RORγt-lineage dendritic cells, and cells expressing Aire called RORγt eTACs (R-eTACs)-also known as Janus or Thetis cells.

Assessing barriers to adjuvant therapy among patients with head and neck cancer in Arkansas.

Advanced head and neck cancer (HNC) requires multimodal treatment and in the setting of primary curative intent surgery, adjuvant radiation with pathology-based chemotherapy is necessary for best outcomes. HNC treatment guidelines and best evidence support adjuvant radiation initiated within 6 weeks of surgery [1]. Over half of HNC patients face obstacles delaying adjuvant therapy, especially in rural areas [2].

In vivo engineering of murine T cells using the evolved adeno-associated virus variant Ark313.

Genetic engineering of T cells in mouse models is essential for investigating immune mechanisms. We aimed to develop an approach to manipulate T cells in vivo using an evolved adeno-associated virus (AAV) capsid named Ark313. Delivery of a transient transgene expression cassette was feasible using Ark313, and this serotype outperformed natural serotypes.

Stimulants Concomitant with Other Psychotropic Classes: A Competing Risk Analysis in Medicaid-Insured Youth.

Pharmacoepidemiologic research shows increasing use of polypharmacy to manage behavioral treatment of youth. Methods to increase precision, for example, competing risk analysis, to capture psychotropic patterns of concomitant stimulant treatment changes over time have not been explored. A retrospective cohort study was derived from Medicaid enrollment data, prescription drug, and clinician-reported diagnosis claims data from 2007 to 2014.

Dual α-globin-truncated erythropoietin receptor knockin restores hemoglobin production in α-thalassemia-derived erythroid cells.

The most severe form of α-thalassemia results from loss of all four copies of α-globin. Postnatally, patients face challenges similar to β-thalassemia, including severe anemia and erythrotoxicity due to the imbalance of β-globin and α-globin chains. Despite progress in genome editing treatments for β-thalassemia, there is no analogous curative option for α-thalassemia.

O-TO-T Advancement Reconstruction for Partial Glossectomy Defects: A Case Series.

We present O-T advancement reconstruction (OTAR) in lateral tongue defects, describing technique, indications, outcomes, and limitations. 11 patients with lateral tongue defects who underwent OTAR after earlystage cancer removal. Demographics, staging, functional oral intake scale (FOIS), dysphagia outcome severity scale (DOSS), defect size, and complications were included.

Outcomes of free flap reconstruction for mandibular ORN: Systematic review and meta-analysis.

Objective: This study aims to evaluate the success rates and complications associated with different free flap donor sites used in surgical reconstruction for mandibular osteoradionecrosis, providing insights to aid clinical decision-making.

Data Sources: MEDLINE, Embase, Cochrane, and Web of Science.

Review Methods: Comprehensive database searches were conducted up to October 2023.

Corn stover variability drives differences in bisabolene production by engineered Rhodotorula toruloides.

Unlabelled: Microbial conversion of lignocellulosic biomass represents an alternative route for production of biofuels and bioproducts. While researchers have mostly focused on engineering strains such as Rhodotorula toruloides for better bisabolene production as a sustainable aviation fuel, less is known about the impact of the feedstock heterogeneity on bisabolene production. Critical material attributes like feedstock composition, nutritional content, and inhibitory compounds can all influence bioconversion.

Four-dimensional computed tomography and ultrasonography for prediction of pathological parathyroid location: a retrospective review of a single surgeon's patients at a single institution.

Background: Pre-operative imaging is a well-established practice for managing hyperparathyroidism with the plan for excision; however, there is a paucity of information regarding the success rate of concordant imaging studies. Our goal was to compare the accuracy (sensitivity) of four-dimensional computed tomography (4DCT) and ultrasound (US) when predicting the side and quadrant of parathyroid lesions, confirmed with surgical location (from a single surgeon).

Methods: A retrospective review of 437 patients from a single surgeon undergoing parathyroidectomy from December 2013 to January 2020 at an academic medical center was performed.

Association between blood transfusion and outcomes of free flap head and neck cancer surgery.

Objective: Investigate the impact of patient risk factors and blood transfusions in Head and Neck free flap surgeries.

Study Design: Retrospective chart review.

Setting: Single tertiary referral center.