Progressive Silent Cerebral Infarction is Associated with Stroke and Persistent Cognitive Impairment in iTTP Survivors.

Immune thrombotic thrombocytopenic purpura (iTTP) survivors face an increased risk of cerebrovascular disease, including silent cerebral infarction (SCI), cognitive impairment, and stroke. The prospective Neurologic Sequelae of iTTP (NeST) study evaluated the natural history of SCI (by brain MRI) during clinical remission and its association with stroke risk and cognitive impairment, measured by the NIH Toolbox Cognition Battery. SCI burden was quantified using the modified Age-Related White Matter Changes (ARWMC) score.