Development of a Machine Learning Model for Determining Alignment in Knees Following Total Knee Arthroplasty.

Background: Malalignment remains a major reason for implant failure following total knee arthroplasty (TKA). Manual analysis of images at a large scale is untenable, and machine learning (ML) models may be a useful tool for determining alignment following TKA and can help identify patients who are at risk for failure. We aimed to develop an ML model that can accurately determine TKA alignment from full-length hip-to-ankle films.

Should We Expand Outpatient Total Joint Selection Criteria? Re-exploring Hard Stop Criteria.

Background: The increasing adoption of same-day discharge (SDD) for total hip (THA) and total knee arthroplasty (TKA) at ambulatory surgical centers (ASCs) has excluded patients who have "hard stop" (HS) medical comorbidities. However, it is believed these criteria better predict 90-day complications than predict SDD failure. Therefore, the purpose of this study was to examine 24-hour and 90 day complications in patients who have and do not have HS comorbidities undergoing THA and TKA.

Reversibility and Enantioselectivity of Palladium-Catalyzed Allylic Aminations: Ligand, Base-Additive, and Solvent Effects.

The enantioselective, palladium-catalyzed reaction of benzylamine with ()-1,3-diphenylallyl ethyl carbonate was examined with 12 different chiral ligands across a range of scaffold types. In 8 out of 12 cases, the observed enantiomeric excess was 36-92% higher when DBU or CsCO was added. Nucleophile crossover experiments between the -benzyl-1,3-diphenylallylamine product and 4-methoxybenzylamine mechanistically linked the changes in enantioselectivity to reformation of the η-allylpalladium intermediate.

Intraoperative robotic measurements of coronal alignment in total knee arthroplasty correlate with pre- and post-operative long-leg radiographs.

Purpose: This study sought to validate intraoperative robotic measurements of femoral and tibial component coronal alignment in total knee arthroplasty (TKA) by comparing to pre- and post-operative standing, double stance, long-leg radiographs (LLR).

Methods: This retrospective cohort study included 59 unique patients undergoing primary TKA at a single institution. Pre- and post-operative femoral and tibial coronal alignment were measured on LLRs using a deep learning artificial intelligence model and compared to measurements obtained from the imageless robotic system to evaluate the robot's accuracy and reliability.

The growth rate of multicolor Ramsey numbers of 3-graphs.

The -color Ramsey number of a -uniform hypergraph ,  denoted (; ), is the minimum integer such that any coloring of the edges of the complete -uniform hypergraph on vertices contains a monochromatic copy of . The study of these numbers is one of the most central topics in combinatorics. One natural question, which for triangles goes back to the work of Schur in 1916, is to determine the behavior of (; ) for fixed and tending to infinity.

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Silica nanoparticles found in sugarcane ash have been postulated to be a toxicant contributing to chronic kidney disease of unknown etiology (CKDu). However, while the administration of manufactured silica nanoparticles is known to cause chronic tubulointerstitial disease in rats, the effect of administering sugarcane ash on kidney pathology remains unknown. Here we investigate whether sugarcane ash can induce CKD in rats.

Exacerbation of Renal, Cardiovascular, and Respiratory Outcomes Associated with Changes in Climate.

Exposure to environmental variables including declining air quality and increasing temperatures can exert detrimental effects on human health including acute exacerbations of chronic diseases. We aim to investigate the association between these exposures and acute health outcomes in a rural community in Colorado. Meteorological and adult emergency department visit data were retrospectively collected (2013-2017); for asthma outcomes, additional data were available (2003-2017).

Urine tungsten and chronic kidney disease in rural Colorado.

Background: Chronic kidney disease (CKD) is a cause of global morbidity and mortality in agricultural communities. The San Luis Valley (SLV) is a rural agricultural community in southern Colorado with geographic and sociodemographic risk factors for CKD, including a water supply contaminated by heavy metals.

Methods: We obtained pre-existing sociodemographic, clinical, and urine trace metal data for 1659 subjects from the San Luis Valley Diabetes Study, a prospective cohort study.

COVID-19 and Public Policy Imperatives: A Trainee Call to Action.

The COVID-19 pandemic has exacerbated the flaws in the U.S. employer-based health insurance system, magnified racial disparities in health and health care, and overwhelmed the country's underfunded public health infrastructure.

Today's Students, Tomorrow's Physicians: Opinions on Enacted and Prospective Health Care Policies.

Future physicians will be key stakeholders in the formation, implementation, and success of health care policies enacted during their careers, though little is known of their opinions of enacted and proposed policies since the 2016 U.S. presidential election.

Looking to the Future: Medical Students' Views on Health Care Reform and Professional Responsibility.

Purpose: Although medical students will influence the future U.S. health care system, their opinions on the Patient Protection and Affordable Care Act (ACA) have not been assessed since the 2016 presidential election and elimination of key ACA provisions.

Acute Illness Associated With Cannabis Use, by Route of Exposure: An Observational Study.

Background: Little is known about the relative harms of edible and inhalable cannabis products.

Objective: To describe and compare adult emergency department (ED) visits related to edible and inhaled cannabis exposure.

Design: Chart review of ED visits between 1 January 2012 and 31 December 2016.

Mental Health-related Emergency Department Visits Associated With Cannabis in Colorado.

Background: Cannabis legalization in Colorado resulted in increased cannabis-associated health care utilization. Our objective was to examine cooccurrence of cannabis and mental health diagnostic coding in Colorado emergency department (ED) discharges and replicate the study in a subpopulation of ED visits where cannabis involvement and psychiatric diagnosis were confirmed through medical review.

Methods: We collected statewide ED International Classification of Diseases, 9th Revision, Clinical Modification diagnoses from the Colorado Hospital Association and a subpopulation of ED visits from a large, academic hospital from 2012 to 2014.

Morphological Spectra of Adult Human Stellate Ganglia: Implications for Thoracic Sympathetic Denervation.

Cardiac sympathetic denervation (CSD) to treat ventricular arrhythmias (VAs) requires transection at the middle or lower third of stellate (cervicothoracic) ganglia (SG). However, the morphological appearance of the adult SG and distribution of neuronal somata within it are not well described. To determine the morphology of left and right SG (LSG and RSG) and the distribution of somata within.

Identifying when choice helps: clarifying the relationships between choice making, self-construal, and pain.

Prior research indicates that making choices before a painful task can sometimes reduce pain. We examined the possibility that independent and interdependent self-construals moderate the effect of choice on pain. Further, we tested between two types of choice: instrumental and non-instrumental.

Clinical implications of novel variants of the fibularis (peroneus) quartus muscle inserting onto the cuboid bone: peroneocuboideus and peroneocalcaneocuboideus.

Two variants of the fibularis (peroneus) quartus muscle were identified and photographed in the legs of a 70-year-old white male cadaver. A rare peroneocuboideus (fibulocuboideus) muscle (as described by Chudzinski) and a novel peroneocalcaneocuboideus (fibulocalcaneocuboideus) muscle was found in the right and left leg, respectively. The latter muscle has not been previously reported and was termed "peroneocalcaneocuboideus" on the basis of its origin and insertions.

Locating the sural nerve during calcaneal (Achilles) tendon repair with confidence: a cadaveric study with clinical applications.

The sural nerve is at risk of iatrogenic injury even during minimally invasive operative procedures to repair the calcaneal (Achilles) tendon. Through 107 cadaveric leg dissections, the data derived from the present study was used to develop a regression equation that will enable surgeons to estimate the intersection point at which the sural nerve crosses the lateral border of the Achilles tendon, an important surgical landmark. In most cases, the sural nerve crossed the lateral border of the Achilles tendon 8 to 10 cm proximal to the superior border of the calcaneal tuberosity.

The fibulocalcaneus (peroneocalcaneus) internus muscle of MacAlister: Clinical and surgical implications.

A fibulocalcaneus (peroneocalcaneus) internus (PCI) muscle (of MacAlister) was identified and photographed in the left leg of a 78-year-old Caucasian female cadaver. This case study provides the first gross anatomical photo of this anomalous leg muscle and represents the first gross anatomical dissection of this muscle since 1914. The PCI muscle arose from the distal third of the fibula, posterior intermuscular septum of the leg, and flexor hallucis longus muscle.

Decision rules guiding the clinical diagnosis of Alzheimer's disease in two community-based cohort studies compared to standard practice in a clinic-based cohort study.

We developed prediction rules to guide the clinical diagnosis of Alzheimer's disease (AD) in two community-based cohort studies (the Religious Orders Study and the Rush Memory and Aging Project). The rules were implemented without informant interviews, neuroimaging, blood work or routine case conferencing. Autopsies were performed at death and the pathologic diagnosis of AD made with a modified version of the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) criteria.