Construction of Silver-Calcium Micro-Galvanic Cell on Titanium for Immunoregulation Osteogenesis.

This work aims to construct a functional titanium surface with spontaneous electrical stimulation for immune osteogenesis and antibacteria. A silver-calcium micro-galvanic cell was engineered on the titanium implant surface to spontaneously generate microcurrents for osteoimmunomodulation and bacteria killing, which provides a promising strategy for the design of a multifunctional electroactive titanium implant. Titanium-based implants are usually bioinert, which often leads to inflammation-induced loosening.

Evaluation of Joint Effect of Frailty and Sleep Health on Cardiometabolic Multimorbidity in Aging Population.

Background: Sleep and frailty are established influencing factors for cardiometabolic diseases (CMDs). However, their joint effects on cardiometabolic multimorbidity (CMM) in older adults remain poorly understood. This study aimed to assess the joint effect of sleep health and frailty on CMD prevalence and severity, with an emphasis on subgroup-specific health risk profiles.

Optimizing dose rate to minimize delivery time in proton pencil beam dose-driven continuous scanning.

Background: Dose-driven continuous scanning (DDCS) enhances the efficiency and precision of proton pencil beam delivery by reducing beam pauses inherent in discrete spot scanning (DSS). However, current DDCS optimization studies using traveling salesman problem (TSP) formulations often rely on fixed beam intensity and computationally expensive interpolation for move spot generation, limiting efficiency and methodological robustness.

Purpose: This study introduces a Break Spot-Guided (BSG) method, combined with two acceleration strategies-dose rate skipping and bounding-to optimize beam intensity while minimizing beam delivery time (BDT).

HMGCS2 attenuates mitochondrial dysregulation and renal fibrosis induced by triclosan.

Renal fibrosis represents a critical pathological mechanism driving the progression of chronic kidney disease toward end-stage renal failure, primarily characterized by the proliferation and deposition of connective tissue within the renal tissue. Triclosan is a widely used synthetic antibacterial agent, and previous studies have demonstrated that TCS exposure interferes with renal fibrosis. However, the pathogenetic mechanism between TCS and renal fibrosis is still unclear.

Enhanced Versus Standard Dermatologic Management With Amivantamab-Lazertinib in EGFR-Mutated Advanced NSCLC: The COCOON Global Randomized Controlled Trial.

Introduction: Amivantamab plus lazertinib significantly improved progression-free and overall survival versus osimertinib in patients with previously untreated, EGFR-mutant advanced NSCLC. EGFR-targeted therapies are associated with dermatologic adverse events (AEs), which can affect quality of life (QoL). COCOON was conducted to assess prophylactic management and improve treatment experience.