Futility indications in resuscitative thoracotomy: A retrospective observational study evaluating practice guidelines.

Background: Resuscitative thoracotomies (RTs) are controversial interventions that heavily consume resources and can pose risks for the surgical team. Increasingly limited resources and risk to healthcare teams have encouraged the continued refinement of RT guidelines. We evaluated RT futility indicators amid institutional RT practice guideline changes.

Diagnostic Odyssey: Primary CNS Lymphoma (Lymphoma Cerebri) Presenting as Rapidly Progressive Dementia.

Primary central nervous system lymphoma (PCNSL) is a rare brain cancer that sometimes presented as rapidly progressive dementia. Diagnosing PCNSL presenting with rapidly progressive neurocognitive symptoms can be challenging, especially when the patient was previously treated with immunosuppressants for suspected autoimmune processes. We present a case where PCNLS was eventually and successfully treated 18 months after neurological symptoms started.

Antimicrobial resistance trends, predictors, and burden in England: a retrospective study using the Clinical Practice Research Datalink from 2015 to 2021.

Objectives: Evidence describing the burden of antimicrobial resistance (AMR) to health care systems is essential to inform health care policy to tackle AMR. This study aims to investigate trends, predictors, and clinical and economic burden of AMR within the English National Health Service.

Methods: We conducted a retrospective cohort study assessing 1,036,850 patients diagnosed with an infection as a hospital inpatient linked to the Clinical Practice Research Datalink within England between 2015 and 2021.