Estimation of Brachial-Ankle Pulse Wave Velocity With Hierarchical Regression Model From Wrist Photoplethysmography and Electrocardiographic Signals: Method Design.

Background: Photoplethysmography (PPG) signals captured by wearable devices can provide vascular age information and support pervasive and long-term monitoring of personal health condition.

Objective: In this study, we aimed to estimate brachial-ankle pulse wave velocity (baPWV) from wrist PPG and electrocardiography (ECG) from smartwatch.

Methods: A total of 914 wrist PPG and ECG sequences and 278 baPWV measurements were collected via the smartwatch from 80 men and 82 women with average age of 63.

Mechanoglycobiology: The Roles of Cell Surface Glycans in Mechanosensing and Mechanotransduction.

Mechanoglycobiology has emerged as a rapidly expanding interdisciplinary field that involves chemistry, biology, and engineering. Despite the great advancements in this field, in-depth investigation of mechanoglycobiology remains challenging due to the complex nature of glycans and cell glycocalyx, as well as the difficulty to mechanically target these biomolecules. To address the issues, novel methods and models have been established to facilitate the investigation of glycan-mediated mechanosensing and mechanotransduction.

Study on the effect of trimethylamine oxide on recurrent cerebral infarction of minor ischaemic stroke rats.

Background: This study investigates the impact of trimethylamine oxide (TMAO) on recurrent cerebral infarction in minor ischemic stroke (MIS).

Methods: A rat model was used, with dietary choline levels adjusted to vary TMAO levels. TMAO was quantified via liquid chromatography-mass spectrometry (LC-MS), and histological changes in brain and aortic tissues were analyzed using HE staining.

Relative brain size explains migratory/resident tendency in birds: Partial altitudinal migration in Asian house martins.

Migration is widespread among animals but varies in its manifestation with differences in direction, distance and obligatory nature. Understanding the evolution of migration requires insight into not only the development of this behaviour but also the loss of it. Partial migration, where some individuals within a population migrate while others stay, provides a unique opportunity to identify the proximate factors determining migratory/resident behaviours.

The Protective Effects of TLR2/NOD2 Combined Agonist CL429 on 14.1 MeV Neutron-Radiation Damage.

High-energy neutron radiation (HENR) induces severe cellular and tissue damage, yet effective prophylactic agents remain limited. In this study, the TLR2/NOD2 co-agonist CL429 was evaluated for its radioprotective potential against 14.1 MeV neutron exposure.