SNAP-3: characteristics of specific subgroups of older patients undergoing surgery in the UK.

Background: The SNAP-3 study reported one in five older surgical patients in the UK were living with frailty and two in three with multimorbidity. We now report characteristics and outcomes of specific subgroups of patients including individuals aged ≥85 yr, undergoing day or inpatient surgery and elective or emergency surgery, and undergoing common specialty procedures including orthopaedics, urology, colorectal surgery, and hip arthroplasty.

Methods: This prospective observational cohort study recruited patients aged ≥60 yr undergoing surgery during five days in March 2022 across 214 UK hospitals.

Texas 2-Step: A new Model for YcgR::c-di-GMP Action at the Flagellar Motor.

Unlabelled: YcgR is a c-di-GMP effector that inhibits both chemotaxis and swimming speed in and . Genetic, biochemical and structural data suggest that YcgR interacts with the bidirectional flagellar rotor as well as the stator to alter rotor bias to CCW and reduce motor speed, but how both feats are achieved remain unclear. Recent cryo-EM structures showing changes in disposition of the rotor and stator units during directional changes suggested to us a mechanism by which YcgR might bring about its action.

Discovery of Osivelotor (GBT021601): A Potent, Next-Generation Sickle Hemoglobin Polymerization Inhibitor.

This report details the discovery path of GBT021601 (osivelotor) (), a novel, small molecule, sickle hemoglobin (HbS) polymerization inhibitor. Following a streamlined testing funnel with cassette dosing in rat pharmacokinetic (PK) studies, we identified this next-generation HbS polymerization inhibitor, which had improved PK properties compared with the first-in-class drug, voxelotor (). GBT021601 has ∼4.

Protocol for the REBOUND study: a cohort study to uncover fundamental mechanisms of accelerated ageing and impaired resilience following cancer surgery and treatment.

Background: Ageing is a heterogeneous process, which is associated with heterogeneous resilience in older people. Cancer surgery and treatment may be associated with accelerated ageing in some older people; studying this process will improve understanding to enable treatments to prevent adverse effects on physical and cognitive function.

Methods: This study will recruit 172 participants aged 65 years and older scheduled to undergo elective colorectal surgery for cancer from two hospital sites (Guy's and St Thomas' NHS Foundation Trust and University Hospitals Birmingham NHS Foundation Trust).