In vivo quantitative assessment of atherosclerotic plaque: A validation study on the optical coherence tomography-derived index of plaque attenuation.

Growing evidence indicates that coronary plaque instability is an independent risk factor for adverse coronary events, yet current optical coherence tomography (OCT) assessment of high-risk plaque characteristics (HRPC) relies largely on qualitative interpretation. The index of plaque attenuation (IPA) is a quantitative OCT-based metric that may provide a more objective evaluation. This retrospective observational diagnostic accuracy study assessed the performance of OCT-derived IPA for HRPC detection in patients with acute coronary syndrome or stable angina, using expert consensus qualitative OCT analysis as the reference standard.

PVC Nanoplastics Exposure Exacerbates Asthma through R-Loop Accumulation and Subsequent STING Activation in Macrophages.

Asthma is a chronic inflammatory respiratory disease influenced by genetic and environmental factors. Emerging evidence suggests that microplastics and nanoplastics (NPs) pose significant health risks. When inhaled, these tiny particles can accumulate in the lungs, triggering inflammation, oxidative stress, and other disruptions in pulmonary function.

Blockade of metastasis by targeting circulating tumor cells with platelet encapsuled oncolytic adenovirus.

Host immune elimination largely limits the application of oncolytic viruses in clinics. Here, we rationally design a bioactive platelet-based oncolytic adenovirus delivery system. Upon loading adenoviruses, platelets are transformed to a pro-endocytosis status, which facilitates their internalization by circulating tumor cells (CTCs).

Co-existence of mcr-1 and bla from porcine-derived Escherichia coli isolated in China and selection of mcr-1 under cephalosporins pressure.

Objectives: The usage of cephalosporins (CEFs) and co-existence of extended-spectrum β-lactamase (ESBL) gene bla in the same host may promote the prevalence of colistin (CST) resistance gene mcr-1. This study aims to investigate the underlying mechanisms how the mcr-1 and bla demonstrate significant co-occurrence in Escherichia coli (E. coli).

Associations between endothelial inflammatory markers and cerebral small vessel disease in a community-based population.

Background: Endothelial inflammation is involved in cerebral small vessel disease (CSVD) pathogenesis. Vascular cell adhesion molecule 1 (VCAM-1) and intercellular adhesion molecule 1 (ICAM-1) are biomarkers of endothelial inflammation.

Aims: This study investigated association of VCAM-1 and ICAM-1 with presence of CSVD and CSVD burden.