Atomically Precise Platinum Nanoclusters: History and Recent Advances in Synthesis, Structure, and Properties.

Platinum is a cornerstone catalyst for various chemical and electrochemical transformations. Atomically precise platinum nanoclusters, located at the transition stage between smaller platinum-ligand coordination molecules (<∼1 nm) and larger platinum colloidal nanoparticles (>∼3 nm), can combine the advantages of both homogeneous and heterogeneous catalysts, serving as model systems for understanding catalytic processes. However, compared to significant advances in coinage metal nanoclusters, atomically precise platinum nanoclusters remain largely unexplored.

Advances in Human Brain Organoids: Methodological Innovations and Future Directions for Drug Discovery.

Background: Understanding the genetic foundations of brain development has been made possible by the use of traditional biological models. However, these models frequently fail to capture the complexity of human brain development, particularly the considerable cortical expansion that sets humans apart from other vertebrates and non-human primates.

Objectives: The purpose of this review is to outline the methodology, applications, and potential prospects for using human brain organoids as sophisticated models for researching brain development and illness mechanisms.

Exploring Thiophene Derivatives: Synthesis Strategies and Biological Significance.

Objectives: Thiophene is one of the most important heterocyclic scaffolds with notable pharmacological properties. Thiophene and its derivatives are of particular interest among sulphurcontaining heterocycles because of their similarities to numerous natural and synthetic compounds with identified potential. The purpose of this study is to extensively analyse the synthetic pathways adopted for synthesising thiophene derivatives and investigate their various biological functions.

Electroceuticals: Unlocking the promise of therapies.

Objectives: Electroceuticals refers to the constantly growing disciplines of bioelectric and bioelectronic medication. These include a broad variety of devices that have been invented and are now being utilized in medical implants, wearable medical electronics, and bioelectronics. The primary aim of this study is to encompass several facets of electroceuticals, their applications, and recent advancements in the field of medical challenges.

Recent Advances in Nitrogen-Containing Heterocyclic Scaffolds as Antiviral Agents.

This study aims to provide a thorough analysis of nitrogen-containing heterocycles, focusing on their therapeutic implications for the development of targeted and effective antiviral drugs. To better understand how nitrogen-containing heterocycles can be used to create antiviral drugs, this review adopts a systematic literature review strategy to compile and analyze pertinent research studies. It combines information from various fields to understand better the compounds' mode of action and their therapeutic potential.

Nitrogen-fused Heterocycles: Empowering Anticancer Drug Discovery.

The worldwide impact of cancer is further compounded by the constraints of current anticancer medications, which frequently exhibit a lack of selectivity, raise safety apprehensions, result in significant adverse reactions, and encounter resistance mechanisms. The current situation highlights the pressing need to develop novel and more precise anticancer agents that prioritize safety and target specificity. Remarkably, more than 85% of drugs with physiological activity contain heterocyclic structures or at least one heteroatom.

An Exploration of Organoid Technology: Present Advancements, Applications, and Obstacles.

Background: Organoids are models that exhibit a three-dimensional structure and effectively replicate the structural and physiological features of human organs. The capacity to research complex biological processes and disorders in a controlled setting is laid out by these miniature organ-like structures.

Objectives: This work examines the potential applications of organoid technology, as well as the challenges and future directions associated with its implementation.

Weapons and Strategies against COVID-19: A Perspective.

Currently, there are no approved treatments for the fatal infectious coronavirus disease. The process of identifying new applications for approved pharmaceuticals is called drug repurposing. It is a very successful strategy for drug development as it takes less time and cost to uncover a therapeutic agent than the de novo procedure.

AI in Health Science: A Perspective.

By helping practitioners understand complicated and varied types of data, Artificial Intelligence (AI) has influenced medical practice deeply. It is the use of a computer to mimic intelligent behaviour. Many medical professions, particularly those reliant on imaging or surgery, are progressively developing AI.

Evaluation of e-cadherin and vimentin expression for different grades of oral epithelial dysplasia and oral squamous cell carcinoma - An immunohistochemical study.

Background: Oral cancer is the 11common cancer in the world and ranks 6globally in deaths. The incidence of oral cancer in India accounts for approximately 30%-40% of all cancers.

Aims And Objective: The present study was undertaken to evaluate the expression of Vimentin and E-cadherin in different grades of oral epithelial dysplasias (OEDs) and oral squamous cell carcinoma (OSCC).

2,4-Diacetylphloroglucinol producing JM-1 for management of ear rot disease caused by in L.

Unlabelled: Maize ( L.) is a major cereal crop grown in a large number of countries. Loss in maize yield due to biotic stresses including fungal phytopathogens is a matter of immense concern.

Short Term Effects of Inner Engineering Completion Online Program on Stress and Well-Being Measures.

Introduction: The Covid-19 pandemic has been a major disruptor of routine life, resulting in increased stress and predisposing people to negative outcomes, such as insomnia, anxiety and hopelessness. Mind-body interventions have improved concentration, emotional balance, and positive emotions, with an enhanced sense of productivity, and self-confidence. We therefore hypothesized that exposure to an online mind-body intervention, "Inner Engineering Completion Online (IECO)," would reduce stress and promote well-being.

Emerging Spacers-Based Ligands for Supramolecular Coordination Complexes.

The design and self-assembly of supramolecular coordination complexes (SCCs) i. e., discrete cyclic metalloarchitectures such as cycles, cages, mesocates, and helicates with desired size, shape, and properties have been increasing exponentially owing to their potential applications in molecular sensors, molecular cargos, molecular recognition, and catalysis.

Secondary Metabolites From Halotolerant Plant Growth Promoting Rhizobacteria for Ameliorating Salinity Stress in Plants.

Soil salinization has emerged as one of the prime environmental constraints endangering soil quality and agricultural productivity. Anthropogenic activities coupled with rapid pace of climate change are the key drivers of soil salinity resulting in degradation of agricultural lands. Increasing levels of salt not only impair structure of soil and its microbial activity but also restrict plant growth by causing harmful imbalance and metabolic disorders.

Epithelial Atrophy, Fibrosis and Vascularity Correlation with Epithelial Dysplasia in Oral Submucous Fibrosis, a Prospective Study.

Background: The pathogenesis of oral submucous fibrosis (OSF) still remains conflicting and has been linked to alterations in epithelial thickness, fibrosis, and vascularity. Although changes in these individual parameters have been extensively studied in relation to epithelial dysplasia their combined relation with dysplasia has not been studied much. Any such relation, if present, may further help in understanding this disease process.

Halo-tolerant plant growth promoting rhizobacteria for improving productivity and remediation of saline soils.

Background: The collective impact of climate change and soil salinity is continuously increasing the degraded lands across the globe, bringing agricultural productivity and food security under stress. The high concentration of salts in saline soils impose osmotic, ionic, oxidative and water stress in plants. Biological solutions can be the most reliable and sustainable approach to ensure food security and limit the use of agro-chemicals.

Novel Bioformulations Developed from BSP9 and its Biosurfactant for Growth Promotion of (L.).

In this study, BSP9 isolated from rhizosphere of was investigated for its plant growth promoting and biosurfactant producing activities. The isolate showed the ability to produce indole acetic acid, siderophore, phosphate solubilization activity and was an efficient producer of biosurfactant. Purification (of the biosurfactant) by thin layer chromatography (TLC) and further characterization by Fourier transform infrared spectroscopy (FTIR) revealed that biosurfactant produced by the isolate belonged to the glycolipid category, which is largely produced by sp.

Mechanisms of halotolerant plant growth promoting sp. involved in salt tolerance and enhancement of the growth of rice under salinity stress.

In the present study halotolerant bacteria were isolated from saline soil (EC ~ 11.9). Based on salt tolerance and plant growth promoting characteristics isolate AF7 was selected for further study.

A Review on Anticancer Activities of Thiophene and Its Analogs.

Cancer is the world's second-largest cause of mortality and one of the biggest global health concerns. The prevalence and mortality rates of cancer remain high despite significant progress in cancer therapy. The search for more effective, as well as less toxic treatment methods for cancer, is at the focus of current studies.