Publications by authors named "Isabelle R Gordon"
Article Synopsis
- * The researchers developed a new method to enhance the extraction of these alpha-synuclein fibrils from postmortem tissue, using solid state nuclear magnetic resonance (SSNMR) to analyze their atomic structure.
- * Their findings reveal that the fibrils from Lewy body dementia consist of both single and double protofilaments, and display structural similarities to previously studied twisted fibrils; this could aid in understanding disease mechanisms and developing new treatments.
Article Synopsis
- - The main feature of Parkinson disease (PD) and Lewy body dementia (LBD) is the buildup of alpha-synuclein (Asyn) fibrils in structures known as Lewy bodies and neurites.
- - A new method was developed to amplify Asyn fibrils from postmortem LBD tissue, allowing researchers to study their atomic structure using solid state nuclear magnetic resonance (SSNMR).
- - The amplified Asyn fibrils consist of two protofilaments with a specific structural arrangement, showing similarities to a previous study, which provides insights for understanding disease mechanisms and potential treatments targeting Asyn.
