Gastrointestinal Device-Mediated Delivery of mRNA-Lipid Nanoparticles Achieves Distinct Expression and Biodistribution in Mice and Pigs.

Recent investigations into autonomous ingestible microjet devices have demonstrated the feasibility of delivering many drug modalities directly into the gastrointestinal (GI) wall via the oral route. However, the expression and biodistribution of mRNA after such injections remain unexplored. mRNA-lipid nanoparticles (mRNA-LNPs) are promising therapeutics for treating or vaccinating against many diseases and pathogens.

Extensive pipeline location data resource: Integrating reported incidents, past environmental loadings, and potential geohazards for integrity evaluations in the U.S. Gulf of Mexico.

The U.S. Gulf of Mexico contains a complex network of existing, decommissioned, and abandoned oil and gas pipelines, which are susceptible to a number of stressors in the natural-engineered offshore system including corrosion, environmental hazards, and human error.

A curated data resource to support safe carbon dioxide transport-route planning.

Supporting the national target of net-zero greenhouse gas emissions in the United States by 2050, the Bipartisan Infrastructure Law (BIL) authorized investments into carbon capture and storage (CCS), highlighting the need for the safe and sustainable transport of carbon dioxide (CO). Curated to support CO pipeline route planning optimization and assess existing energy transport corridors, the CCS Pipeline Route Planning Database is a compilation of 47 publicly available, authoritative geospatial data resources, spanning the contiguous U.S.

Composition and Origin of Surface Casing Fluids in a Major US Oil- and Gas-Producing Region.

Fluids leaked from oil and gas wells often originate from their surface casing─a steel pipe installed beneath the deepest underlying source of potable groundwater that serves as the final barrier around the well system. In this study, we analyze a regulatory dataset of surface casing geochemical samples collected from 2573 wells in northeastern Colorado─the only known publicly available dataset of its kind. Thermogenic gas was present in the surface casings of 96.