Publications by authors named "Isabelle Filipiak"
The psychoendocrine evaluation of lamb development has demonstrated that maternal deprivation and milk replacement alters health, behavior, and endocrine profiles. While lambs are able to discriminate familiar and non-familiar conspecifics (mother or lamb), only lambs reared with their mother develop such clear social discrimination or preference. Lambs reared without mother display no preference for a specific lamb from its own group.
View Article and Find Full Text PDFBackground: Thrombus composition has the potential to affect acute ischemic stroke (AIS) treatment.
Objective: To evaluate in an in vitro test the correlation of clot composition, especially erythrocytes (red blood cells (RBCs)), with the variation of signal intensity ratio (SIR) obtained with MRI sequences used for AIS, and qualification of the susceptibility vessel sign effect using clot analogs.
Materials And Methods: Nine ovine clots were fixed in a gelatin-manganese solution and studied by MRI (T2GE, T2-weighted gradient echo; SWI, susceptibility-weighted imaging; FLAIR, fluid attenuated inversion recovery).
Article Synopsis
- Genetic polymorphisms, specifically the Val158Met variant of the Catechol-O-Methyltransferase gene, significantly affect white matter structure and brain function development in healthy adults.
- Using diffusion-weighted imaging and Tract-Based Spatial Statistics, the study analyzed white matter integrity in a sample of 82 healthy individuals.
- Findings revealed that the interaction between genotype and sex influences the morphology of the corpus callosum, with male homozygotes showing higher fractional anisotropy compared to female carriers.
Article Synopsis
- Anaplastic gangliogliomas (GGGs) are rare brain tumors with unclear progression patterns; this study examined their clinical, imaging, and prognostic features in a group of 43 adult patients from a French database over a ten-year period.* -
- Patients commonly presented with neurological deficits, seizures, or increased intracranial pressure, and imaging typically showed unifocal tumors with features like enhancement and necrosis; treatment often involved surgery followed by radiotherapy.* -
- The study found that while the overall survival rates are slightly better than glioblastomas, tumor characteristics such as midline crossing and location can impact survival; however, no factors remained significant in advanced statistical analysis.*
Introduction: Diffusion tractography relies on complex mathematical models that provide anatomical information indirectly, and it needs to be validated. In humans, up to now, tractography has mainly been validated by qualitative comparison with data obtained from dissection. No quantitative comparison was possible because Magnetic Resonance Imaging (MRI) and dissection data are obtained in different reference spaces, and because fiber tracts are progressively destroyed by dissection.
View Article and Find Full Text PDFAutism spectrum disorders (ASD) are neurodevelopmental diseases with complex genetic and environmental etiological factors. Although genetic causes play a significant part in the etiology of ASD, metabolic disturbances may also play a causal role or modulate the clinical features of ASD. The number of ASD studies involving metabolomics is increasing, and sometime with conflicting findings.
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