Publications by authors named "Irina Simonova"
Article Synopsis
- Cardiomyocytes in adult human hearts have a low regeneration rate of about 0.5% per year, raising questions about their role in heart failure recovery.
- Patients with advanced heart failure showed dramatically reduced cardiomyocyte renewal, with rates significantly lower than healthy individuals, while those with left ventricular assist devices (LVAD) experienced a notable increase in regeneration.
- These results suggest that the heart retains a potential for regeneration in disease states, which could be harnessed for future therapies.
Cardiomyocytes in the adult human heart show a regenerative capacity, with an annual renewal rate around 0.5%. Whether this regenerative capacity of human cardiomyocytes is employed in heart failure has been controversial.
View Article and Find Full Text PDFPhysiological liver cell replacement is central to maintaining the organ's high metabolic activity, although its characteristics are difficult to study in humans. Using retrospective radiocarbon (C) birth dating of cells, we report that human hepatocytes show continuous and lifelong turnover, allowing the liver to remain a young organ (average age <3 years). Hepatocyte renewal is highly dependent on the ploidy level.
View Article and Find Full Text PDFOne of the major goals in cardiac regeneration research is to replace lost ventricular tissue with new cardiomyocytes. However, cardiomyocyte proliferation drops to low levels in neonatal hearts and is no longer efficient in compensating for the loss of functional myocardium in heart disease. We generated a human induced pluripotent stem cell (iPSC)-derived cardiomyocyte-specific cell cycle indicator system (TNNT2-FUCCI) to characterize regular and aberrant cardiomyocyte cycle dynamics.
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