Publications by authors named "Imene Mansouri"
Research Question: Are there significant differences between cumulative live birth rates (CLBR) after short or extended embryo culture when comparisons are performed per cycle?
Design: This French national study included all IVF cycles performed from January 2016 to December 2019 with at least one cleaved embryo at day 2. The day 2/3 and day 5/6 groups were identified using the National Biomedicine Agency register. Only attempts involving the vitrification method were included.
Introduction: In women receiving chronic dialysis, fertility is impaired. The objectives of this study were to estimate the incidence rate of pregnancies among women of childbearing age (15-50 years) receiving chronic dialysis from 2006 to 2020 in France, to describe the pregnancy outcomes and renal management during pregnancy.
Methods: This national observational, retrospective study was based on data from the French REIN registry matched with the National Health Data System.
Article Synopsis
- The study aimed to estimate the prevalence of chronic kidney disease (CKD) in France using the RENALGO-EXPERT algorithm, focusing on healthcare consumption data from the French National Health claims database between 2018 and 2021.
- The results showed an increase in estimated CKD prevalence from 8.1% to 10.5% over the years, with the algorithm having a low positive predictive value (6.2%) and a high negative predictive value (99.1%).
- The findings highlight that while the algorithm can help identify CKD patients in typical care pathways, it has limitations in accurately detecting undiagnosed or early-stage patients, indicating a need for more comprehensive assessment methods
Article Synopsis
- A study examined how well long-term childhood cancer survivors at high risk for cardiomyopathy followed cardiac screening guidelines, involving nearly 1,000 patients.
- Only 32% of participants had an echocardiogram in the last five years, with lower adherence among males, older survivors, and those with specific cancer types like Neuroblastoma and CNS tumors.
- Attending long-term follow-up visits significantly increased the likelihood of completing echocardiograms, highlighting the need for better strategies to encourage more survivors to participate in recommended cardiac surveillance.
Risk of Renal or Urinary Related Hospitalization in Survivors of Childhood Cancer: Results from the French Childhood Cancer Survivor Study.
Cancer Epidemiol Biomarkers Prev
April 2023
Article Synopsis
- Hospitalization rates indicate that childhood cancer survivors (CCS) face significantly higher risks related to renal and urinary diseases compared to the general population, particularly within 5 years post-treatment.
- The study analyzed data from a large cohort of CCS, revealing that these survivors have 2.9 times more renal-related hospitalizations, with specific treatments like high-dose ifosfamide increasing risks substantially.
- Findings emphasize the importance of long-term monitoring for renal health in CCS, especially for those with a history of nephrectomy or extensive radiation exposure.
Background And Purpose: Valvular Heart Disease (VHD) is a known complication of childhood cancer after radiotherapy treatment. However, the dose-volume-effect relationships have not been fully explored.
Materials And Methods: We obtained individual heart Dose Volume Histograms (DVH) for survivors of the French Childhood Cancer Survivors Study (FCCSS) who had received radiotherapy.
Background Since July 2018, numerous lots of valsartan have been found to be contaminated with -nitrosodimethylamine (NDMA). We aimed to assess the association between exposure to valsartan products contaminated with NDMA and the risk of cancer. Methods and Results This study was based on data from the Système National des Données de Santé, which is a national database that includes all French residents' health-related expenses.
View Article and Find Full Text PDFBackground: Published algorithms for identifying chronic kidney disease in healthcare claims databases have poor performance except in patients with renal replacement therapy. We propose and describe an algorithm to identify all stage chronic kidney disease in a French healthcare claims databases and assessed its performance by using data from the Renal Epidemiology and Information Network registry and the French Childhood Cancer Survivor Study cohort.
Methods: A group of experts met several times to define a list of items and combinations of items that could be related to chronic kidney disease.
Smoking and Cannabis Use among Childhood Cancer Survivors: Results of the French Childhood Cancer Survivor Study.
Cancer Epidemiol Biomarkers Prev
October 2021
Background: Unhealthy behaviors among childhood cancer survivors increase the risks for cancer treatment adverse effects. We aimed to assess tobacco and cannabis use prevalence in this population and to identify factors associated with these consumptions.
Methods: This study involved 2,887 5-year survivors from the French childhood cancer survivor study (FCCSS) cohort.
Article Synopsis
- The study investigates radiation exposure levels in medical imaging facilities in Benin, focusing on X-ray and CT scan rooms, due to increasing occupational doses from expanded radiological procedures.
- It involved 72 medical centers and used calibrated radiometers to measure exposure levels, comparing the results against established reference levels for both workers (7.50 µSv/h) and the public (0.05 µSv/h).
- Findings revealed that 13.04% of the control areas behind lead glass exceeded occupational limits, and 40% of entrance doses were above public safety standards, indicating potential safety concerns in the current protective measures.
Article Synopsis
- Intensive treatments with high-dose chemotherapy and stem cell rescue have improved survival rates for high-risk neuroblastoma (HRNB) patients, with a study following 145 survivors 15 years post-treatment showing promising long-term outcomes.
- However, the study revealed significant late effects, including late relapses and the development of second malignant neoplasms, indicating a need for ongoing monitoring and support for these survivors.
- Additionally, HRNB survivors experienced various non-cancer-related health issues, such as dental maldevelopment and organ-specific complications, with near-universal gonadal insufficiency noted in those treated with busulfan.
Objective: Health risk behaviors (HRB) of childhood cancer survivors (CCS) are generally studied separately, despite the evidence suggesting that HRB are not independent. To our knowledge, few studies have examined HRB profiles in the former pediatric cancer patients. In this study, we identified HRB profiles and examined predictors engaging in unhealthy behaviors in CCS.
View Article and Find Full Text PDFArticle Synopsis
- Cancer treatments and nephrectomy are leading to an increase in kidney failure cases, which is concerning as cancer survival improves; the study focused on kidney failure from antineoplastic agents and urinary tract cancers.
- Data was gathered from the French Renal Epidemiology and Information Network registry between 2003-2015, identifying 287 nephrotoxin-related and 1157 urinary tract cancer-related kidney failure cases, compared to a larger control group of 11,678 patients with different kidney issues.
- Results showed a rise in kidney failure incidence rates, higher mortality risks for patients with nephrotoxin-related issues, and significantly lower chances of being waitlisted for kidney transplants for these patients versus controls, particularly when cancer was
Risk of subsequent primary leukaemias among 69,460 five-year survivors of childhood cancer diagnosed from 1940 to 2008 in Europe: A cohort study within PanCareSurFup.
Eur J Cancer
August 2019
Background: Survivors of childhood cancers are at risk of developing subsequent primary leukaemias (SPLs), but the long-term risks beyond 20 years of treatment are still unclear. We investigated the risk of SPLs in five-year childhood cancer survivors using a large-scale pan-European (PanCareSurFup) cohort and evaluated variations in the risk by cancer and demographic factors.
Methods: This largest-ever assembled cohort comprises 69,460 five-year childhood cancer survivors from 12 European countries.
Article Synopsis
- Childhood cancer survivors (CCS) have an increased risk of heart failure (HF), yet how radiation affects heart volumes and their link to HF in this group is under-researched.
- A study analyzed data from 239 HF cases compared to 1,042 controls, finding that a significant portion of the heart receiving radiation (≥ 30 Gy) was associated with a higher HF risk, particularly in those who didn’t receive anthracyclines.
- This research establishes a connection between small irradiated heart volumes and HF risk, marking a new understanding that could improve clinical treatment practices for CCS.
Risk of subsequent colorectal cancers after a solid tumor in childhood: Effects of radiation therapy and chemotherapy.
Pediatr Blood Cancer
February 2019
Background: Very few previous studies have addressed the question of colorectal cancer (CRC) after childhood cancer treatment. We aimed to quantify the roles of radiation therapy and chemotherapy agents in the occurrence of subsequent CRC.
Methods: A nested case-control study was conducted using 36 CRC cases and 140 controls selected from 7032 five-year survivors of the French Childhood Cancer Survivor Study (FCCSS) cohort, treated from 1945 to 2000 in France.
As modern radiotherapy, including intensity-modulated techniques, is associated with high dose gradients to normal tissues and large low-to-moderate dose volumes, the assessment of second primary cancer (SPC) risks requires quantification of dose-volume effects. We conducted a systematic review of clinical and epidemiological studies investigating the effect of the irradiated volume or dose-volume distribution to the remaining volume at risk (RVR) on SPC incidence. We identified eighteen studies comparing SPC risks according to the irradiated volume (i.
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