Establishing and Maintaining 3D Organoid Cultures From Human Fallopian Tube Epithelium.

The female reproductive tract is comprised of different regions, each with distinctive physiological characteristics. One of them is the fallopian tubes, which are vital for human reproductive health and success. The ability to model their function and physiology is of utmost importance.

Validation of an instrument prototype for the minimally invasive fetal surgery of gastroschisis in an inanimate model.

Introduction: Complex gastroschisis requires timely intervention to protect the fetal intestine from inflammation and strangulation and avoid viscero-abdominal disproportion (VAD). Earlier results in ovine models for the fetoscopic management of gastroschisis highlight the benefits of minimally invasive coverage; yet specialized instruments appear to be needed for better procedural execution. The aim of this study was to create and validate a first prototype instrument for the prenatal covering of the protruded intestines in gastroschisis.

Impact of Gynecological Interventions on Pelvic Floor Disorders: A Descriptive Analysis of a Case Series in a Hospital-Based Surgical Cohort of 832 Patients.

: Pelvic floor disorders (PFDs) have multifactorial etiology. This makes treatment challenging and often unsatisfactory. This project introduces robust data on risk factors for PFDs and explores opportunities for their prevention, focusing on previous gynecological surgical interventions.

Right Colectomy with Complete Mesocolic Excision and Intracorporeal Anastomosis: A Monocentric, Single-Surgeon Comparison of Dexter, DaVinci and Laparoscopic Approaches.

(1) Minimally invasive techniques are standard in colorectal surgery, though complete mesocolic excision (CME) with central lymphadenectomy remains technically demanding. Robotic systems may address these challenges. While the DaVinci system is well established, the modular Dexter system allows rapid switching between laparoscopy and robotics.

Is the duration of surgical experience associated with a diverse range of individual personality traits?

Background: Surgery, a field marked by constant advancements in technique, calls for specific personality traits. The improvement of skills requires lifelong motivation, critical thinking and openness to new technologies. However, it remains unclear whether there is an association between the expression of personality traits such as motivation or critical thinking, and the duration of work experience.

Maternal and newborn health inequality among Syrian refugees in Turkey: a systematic review and meta-analysis.

Objective: In this meta-analysis we explore significant health disparities in maternal and newborn health among Syrian refugees residing in Turkey.

Method: The study protocol was registered in PROSPERO. We conducted a comprehensive literature search across six databases, including sources in English and Turkish, as well as relevant UN agencies, covering the period from 2011 (the onset of the Syrian conflict) to September 2024.

Utility of CA-125 for diagnosis and prognosis of breast cancer: a systematic review.

Background: Different tumor markers are utilized in the assessment of breast cancer. The function of these markers in assessing, tracking, and following up on breast cancer has drawn the interest of numerous researchers. Nonetheless, contradictory findings from research continue to raise questions regarding their effectiveness.

A non-randomized study of sexual health education on the sexual function of primigravid women.

Background: Sexual function is a particularly important aspect of pregnant women's lives that can affect mental health and family cohesion.

Aim: This study aimed to determine the effect of sexual health education on sexual function in primigravida women.

Methods: In a non-randomized study, primigravida women were divided into an intervention group (n = 43) and a control group (n = 43).

Causes and Factors Affecting Cesarean Hysterectomy: A Retrospective Study.

: Cesarean hysterectomy is a critical intervention often required to manage life-threatening postpartum hemorrhage (PPH) due to complications such as uterine atony, abnormal placental implantation, or traumatic rupture. Although lifesaving, the procedure is associated with significant risks and complications. This study investigates the causes and outcomes of cesarean hysterectomy, focusing on complications arising from the procedure.

Early Pregnancy Loss in the 1st Trimester: Guideline of the DGGG, OEGGG and SGGG (S2k-Level, AWMF Registry No. 015/076; August 2024).

This guideline aims to improve and standardize the diagnostic and therapeutic approaches for different types of miscarriages, pregnancies of unclear localization, and ectopic pregnancies in the 1st trimester. In accordance with the requirements for an S2k-guideline, this guideline was compiled following a search of the literature, and the various recommendations and statements were formally agreed upon by an interdisciplinary group of representative experts from Germany (DGGG, etc.), Austria (OEGGG) and Switzerland (SGGG) who met up several times under the aegis of the German Society for Gynecology and Obstetrics ( , DGGG).

How effective and sustainable is proctoring in robotic surgery? A retrospective analysis based on interviews with surgeons.

Background: Robot-assisted surgery is one of several minimally invasive techniques which have become increasingly important in recent years. Education and training are key factors of sustainable success, and surgical tutoring by an experienced external surgeon (proctoring) has emerged as a very useful method of training surgeons. Proctoring enables surgeons to train their respective skills and eventually improve the overall quality of surgical care.

Global prevalence and risk factors of obstetric violence: A systematic review and meta-analysis.

Background: Obstetric violence (OBV), defined as mistreatment or abuse during childbirth, is a pervasive global issue, albeit with regional differences, affecting women's physical and emotional well-being.

Objectives: The purpose of this systematic review and meta-analysis is to assess the prevalence of OBV to identify risk factors associated with OBV and to make suggestions for improving maternal healthcare practices and policies.

Search Strategy: In a systematic review and meta-analysis, we searched four electronic databases for studies published over 10 years up to 31 January 2024: Medline (PubMed), Scopus, Embase, and Web of Science (WOS).

Adhesion Prevention in Gynecologic Surgery: Guidance and Clinical Experience.

Postoperative adhesions represent a major medical challenge and are associated with serious health and economic consequences. 4DryField PH (PlantTec Medical GmbH, Lueneburg, Germany) is a starch-based medical device designed both to prevent adhesions and for hemostasis. This paper explores methods to successfully apply it in gynecological surgery, leveraging the authors' extensive clinical experience.

Global trend of cervical cancer among women aged 55 and older from 2010 to 2019: An analysis by socio-demographic index and geographic regions.

Objective: This study describes the 2010-2019 trend of cervical cancer (CC) in women over 55 by socio-demographic index (SDI) and geographical regions.

Methods: We obtained data on CC annually from 2010 to 2019 from the 2019 Global Burden of Disease Study (GBD) to analyze the incidence, death and prevalence rates, and disability-adjusted life years (DALYs) associated with CC across different parameters such as global trend, age groups, SDI, continents, World Bank Regions, World Health Organization (WHO) regions, GBD regions, and National and territorial division. This analysis covers data from 204 countries and territories from 1990 to 2019.

Cesarean scar niche: comparison of transvaginal ultrasound findings and uterine tissue samples after hysterectomy.

Background: The cesarean scar niche, a consequence of incomplete wound healing, can lead to gynecological complications and affect future pregnancies. While internal niches have been well-studied, external and bidirectional niches are also important.

Objective: We aimed to conduct a comparative analysis of the prevalence and measurements of different types of niches.

Comparison of three umbilical entry sites for intraperitoneal access by the direct trocar insertion technique: a randomized pilot study.

Objective: The most effective methods and entry sites for laparoscopic surgery remain a subject of ongoing investigation and discussion. The purpose of the study was to analyze and compare three umbilical entry sites for intraperitoneal access using the direct trocar insertion technique.

Material And Methods: A randomized pilot study was conducted between March 2021 and January 2023, involving women eligible for laparoscopic gynecological surgery.

Neuropelveology for Endometriosis Management: A Systematic Review and Multilevel Meta-Analysis.

: Despite the availability of treatments such as surgery and hormonal therapy, women with endometriosis often endure chronic problems. This review aims to evaluate the effectiveness and safety of neuropelveology. : In a systematic review with a meta-analysis, we searched three electronic databases: MEDLINE (PubMed), Scopus, Embase, and Web of Science (WOS).

[Fostering young talents for surgery : Laparoscopy in preclinical education-Too early or exactly right?].

Background: Due to the declining interest among medical students in pursuing a surgical career, the impact of demographic changes and the technical challenges, there is an increasing need to attract medical students to the surgical profession. Against this backdrop, a teaching project was developed to familiarize medical students with minimally invasive surgical techniques early in the preclinical education, thereby increasing the interest in surgery.

Material And Methods: Within the framework of the regular anatomical dissection course the following modules on laparoscopic surgery were integrated: (1) clinical lecture on the technique and application of laparoscopy, (2) exploratory live laparoscopy on a body donor and (3) practical exercises on laparoscopic trainers.

The Combination of Laparoscopic and Robotic Surgery: First Experience with the Dexter Robotic System™ in Visceral Surgery.

Introduction: For over two decades, abdominal surgical procedures have been safely performed robotically. After the first patent expiration, alternative robotic systems entered the market. The Dexter Robotic System™ is a small-format, modular, and robotic platform consisting of a surgeon's console, two patient carts with instrument arms, and one endoscope arm.

Prevention of peritoneal adhesions after gynecological surgery: a systematic review.

Importance: The formation of adhesions after gynecological surgery not only has detrimental impacts on those affected, including pain, obstruction, and infertility, but also imposes a high economic burden on healthcare systems worldwide.

Objective: The aim of this review was to evaluate the adhesion prevention potential of all currently available adhesion barriers for gynecological surgery.

Evidence Acquisition: We systematically searched MEDLINE and CENTRAL databases for randomized controlled trials (RCTs) on the use of adhesion barriers as compared with peritoneal irrigation or no treatment in gynecological surgery.