Do neonatal intensive care unit (NICU) health workers know about retinopathy of prematurity (ROP)? A qualitative study at a Regional Referral Hospital in Uganda.

Introduction: Retinopathy of prematurity (ROP) is a significant cause of blindness and visual impairment in preterm infants globally, particularly in low-income and middle-income countries. ROP is associated with prematurity, and with the increase in the survival of preterm infants, its global burden continues to rise. However, there is limited information available on health workers' perspectives regarding ROP in Uganda.

Intravenous Iron as an Alternative to Blood Transfusion in Cancer Patients: A Single Center Experience.

Anemia is common in cancer patients receiving palliative care, causing significant symptom burden and transfusion requirement. While intravenous (IV) iron is recognized for its role in chemotherapy-induced anemia, its efficacy in broader palliative oncology settings is underexplored. Our study provides real-world experience with IV iron in cancer patients, particularly those receiving supportive care alone.

INTRAOCULAR INFLAMMATION ASSOCIATED WITH FARICIMAB THERAPY: One-Year Real-World Outcomes.

Purpose: To report 1-year real-world evidence on intraocular inflammation (IOI) adverse events in patients undergoing faricimab therapy in a tertiary care hospital.

Methods: A retrospective review of electronic medical records was conducted for patients receiving faricimab treatment for neovascular age-related macular degeneration and diabetic macular edema at Moorfields Eye Hospital between September 1, 2022, and August 31, 2023. The primary outcome was the incidence of IOI (excluding endophthalmitis).

Treatment of chronic diabetic macular oedema with intravitreal fluocinolone acetonide implant; real-life analysis of outcomes during overall treatment period.

Purpose: To assess the clinical efficacy of the fluocinolone acetonide (FA) intravitreal implant (, ) over a 12-month period in a population resistant to treatment with first-line anti-VEGF agents.

Methods: This study is a retrospective cohort study assessing functional and anatomical outcomes in 13 eyes of 12 patients treated for diabetic macular oedema (DMO) with a single fluocinolone implant (FA) ( under real-world conditions. The follow-up period includes the time of first intravitreal treatment (incl anti-VEGF or short-lasting steroids) given until 12 months post FA implant insertion.

Characterization of Ebola Virus-Associated Eye Disease.

Importance: Survivors of Ebola virus disease (EVD) may experience ocular sequelae. Comparison with antibody-negative individuals from the local population is required to characterize the disease.

Objective: To assess features of ophthalmic disease specific to EVD.

Logistic Regression Classification of Primary Vitreoretinal Lymphoma versus Uveitis by Interleukin 6 and Interleukin 10 Levels.

Purpose: To assess the diagnostic performance and generalizability of logistic regression in classifying primary vitreoretinal lymphoma (PVRL) versus uveitis from intraocular cytokine levels in a single-center retrospective cohort, comparing a logistic regression model and previously published Interleukin Score for Intraocular Lymphoma Diagnosis (ISOLD) scores against the interleukin 10 (IL-10)-to-interleukin 6 (IL-6) ratio.

Design: Retrospective cohort study.

Participants: Patient histories, pathology reports, and intraocular cytokine levels from 2339 patient entries in the National Eye Institute Histopathology Core database.

Immunohistochemical characterization of feline lymphoplasmacytic anterior uveitis.

Objective: To characterize the immune cells present in different forms of feline anterior uveitis.

Samples: Eyes were obtained from 49 cats diagnosed with chronic idiopathic lymphoplasmacytic anterior uveitis, 7 cats with feline infectious peritonitis (FIP), and 9 cats euthanized for nonocular disease.

Methods: H&E sections were scored on the level of infiltrate in the anterior uvea.

Gradient Boosted Decision Tree Classification of Endophthalmitis Versus Uveitis and Lymphoma from Aqueous and Vitreous IL-6 and IL-10 Levels.

Purpose: To investigate the effectiveness of gradient boosting to classify endophthalmitis versus uveitis and lymphoma by intraocular cytokine levels.

Method: Patient diagnoses and aqueous and vitreous levels of interleukin (IL)-6 and IL-10 were retrospectively extracted from a National Eye Institute Histopathology Core database and compared by Kruskal-Wallis and post hoc Dunn tests. A gradient-boosted decision tree classifier was trained to differentiate endophthalmitis versus uveitis and lymphoma from vitreous IL-6 and IL-10, vitreous IL-6 only, and aqueous IL-6 only data sets; and was tested with 80-20 train-test split and 3-fold cross-validation of the training set.

The role of sex in uveitis and ocular inflammation.

Uveitides can be due to non-infectious and infectious etiologies. It has been observed that there is a gender difference with a greater preponderance of non-infectious uveitis in women than in men. This review will describe both non-infectious and infectious uveitides and describes some of the current autoimmune mechanisms thought to be underlying the gender difference.

Cytomegalovirus retinitis complicating combination therapy with rituximab and fludarabine.

Cytomegalovirus (CMV) retinitis is exceptionally rare outside the clinical context of acquired immunodeficiency syndrome and organ allografting. In a population where seropositivity for past CMV infection exceeded 90 %, CMV retinitis was observed in five of 138 patients (3.6 %) receiving fludarabine-containing regimens together with rituximab, which was significantly more frequent than in 141 patients receiving fludarabine-containing regimens alone, where no case was observed (P = 0.

Sequential therapy with ranibizumab and dexamethasone intravitreal implant is better than dexamethasone monotherapy for macular oedema due to retinal vein occlusion.

Purpose: To evaluate the efficacy and safety of sequential therapy with ranibizumab followed by dexamethasone intravitreal implant compared with dexamethasone monotherapy for macular oedema (MO) secondary to retinal vein occlusion (RVO).

Methods: In this retrospective interventional study, the medical records of subjects with MO due to RVO who received either ranibizumab followed by dexamethasone intravitreal implant (Group 1) or dexamethasone-implant monotherapy (Group 2) were included. Primary outcome was the proportion of subjects who exhibited best-corrected visual acuity (VA) gain and resolution of MO within 6 months.

Occlusion therapy in amblyopia: an experience from Hong Kong.

OBJECTIVES. To review the results of patching for amblyopia management in Hong Kong. DESIGN.

Simultaneous spectral domain OCT and fundus autofluorescence imaging of the macula and microperimetric correspondence after successful repair of rhegmatogenous retinal detachment.

Background/aims: To evaluate the ultrastructural changes in the macula after successful repair of rhegmatogenous retinal detachment (RRD) using simultaneous spectral domain optical coherence tomography (sdOCT) and fundus autofluorescence (FAF) imaging and to perform functional correlations with microperimetry.

Methods: Simultaneous sdOCT and FAF imaging were performed using a combined sdOCT-confocal scanning laser ophthalmoscope (cSLO) system. Microperimetry was performed in a subgroup of these patients.

Photorefractive keratectomy (PRK) versus laser assisted in situ keratomileusis (LASIK) for hyperopia correction.

Background: Hyperopia, or hypermetropia (also known as long-sightedness or far-sightedness), is the condition where the unaccommodating eye brings parallel light to a focus behind the retina instead of on it. Hyperopia can be corrected with both non-surgical and surgical methods, among them photorefractive keratectomy (PRK) and laser assisted In situ keratomileusis (LASIK). There is uncertainty as to whether hyperopic-PRK or hyperopic-LASIK is the better method.

The use of the Ocular Response Analyser to determine corneal hysteresis in eyes before and after excimer laser refractive surgery.

Purpose: To compare corneal biomechanical parameters and two measures of intraocular pressure (IOP) in eyes before and after excimer laser refractive surgery, with the Ocular Response Analyser (ORA).

Materials And Methods: Eighty normal eyes of 41 patients undergoing excimer laser refractive surgery in Birmingham, U.K.

Correlation of Nidek OPD-Scan objective refraction with subjective refraction.

Purpose: The aim of this study was to quantify how closely the Nidek OPD-Scan objective refraction correlated with subjective refraction.

Methods: A retrospective audit of the preoperative refraction of 80 myopic and myopic astigmatic eyes before laser in situ keratomileusis (LASIK) or laser supepithelial keratomileusis (LASEK) was performed. Objective refraction in the 5-mm zone was performed using a Nidek OPD-Scan.

Aspheric ablation with the Nidek EC-5000 CX II with OPD-Scan objective analysis.

Purpose: To analyze the efficacy, predictability, stability, and safety of laser in situ keratomileusis (LASIK) to correct myopia and myopic astigmatism using the Nidek EC-5000 CX II laser and the Customized Aspheric Transition Zone (CATz) profile.

Methods: We conducted a retrospective analysis of 100 eyes (50 patients) with myopic astigmatism. A CATz profile was used in all eyes (profile 4) with an ablation zone of 5 mm and a transition zone of 9 mm, using Nidek FinalFit software.

Higher order aberrations with aspheric ablations using the Nidek EC-5000 CX II laser.

Purpose: To analyze the change in higher order aberrations in myopic and myopic astigmatic eyes following an aspheric ablation profile for laser in situ keratomileusis (LASIK) using a Nidek EC-5000 CX II excimer laser system.

Methods: We performed a retrospective audit of 38 eyes (19 patients) with myopia and myopic astigmatism. A customized aspheric transition zone profile (CATz) was used in all eyes (profile 4) with an ablation zone of 5 mm and a transition zone of 9 mm using FinalFit software and a Nidek EC-5000 CX II excimer laser system.