Cancer-Specific and Pro-Apoptotic PEGylated Liposomes Containing SMAC-Mimetic Doxorubicin Prodrug for Safe High-Dose Delivery in Pancreatic Cancer.

High-dose chemotherapy exhibits potent therapeutic efficacy in pancreatic cancer. However, its application is often limited because of severe toxicity and drug resistance. Herein, a high-dose therapy of pro-apoptotic doxorubicin (DOX) prodrug-encapsulated PEGylated liposomes (Aposomes) is presented for the treatment of pancreatic cancer.

Nanomechanical Insights into Enhancing Flexibility and Reliability in Deformable Optoelectronic Devices.

The demand for deformable optoelectronic devices that are bendable, stretchable, and foldable has significantly increased. Accordingly, recent research has focused on ensuring the flexibility and stretchability of devices under various deformation modes, making the evaluation and enhancement of the mechanical reliability crucial. Here, we review strategies to improve the flexibility and stretchability of deformable optoelectronic devices, including intrinsic approaches to increasing the elastic deformation limit of materials and extrinsic structural design strategies at the device level.

Overcoming Cancer Drug Resistance with Nanoparticle Strategies for Key Protein Inhibition.

Drug resistance remains a critical barrier in cancer therapy, diminishing the effectiveness of chemotherapeutic, targeted, and immunotherapeutic agents. Overexpression of proteins such as B-cell lymphoma 2 (Bcl-2), inhibitor of apoptosis proteins (IAPs), protein kinase B (Akt), and P-glycoprotein (P-gp) in various cancers leads to resistance by inhibiting apoptosis, enhancing cell survival, and expelling drugs. Although several inhibitors targeting these proteins have been developed, their clinical use is often hampered by systemic toxicity, poor bioavailability, and resistance development.

Association between Phytochemical Index and Osteoporosis in Women: A Prospective Cohort Study in Korea.

Osteoporosis is a prevalent issue among postmenopausal women, who have a higher incidence of the condition than men. This study aimed to examine the relationship between phytochemical-rich food intake and osteoporosis incidence in premenopausal and postmenopausal women. The data analyzed included 4600 women aged 40-69 who were free of osteoporosis at baseline, with dietary intake evaluated through a semi-quantitative food frequency questionnaire and osteoporosis prevalence determined using interviewer-administered questionnaires and bone mineral density tests.

Sugar-Sweetened Coffee Intake and Blood Glucose Management in Korean Patients with Diabetes Mellitus.

One of the most frequently consumed beverages by Korean adults is 3-in-1 coffee (mixed coffee) with sugar and creamer. Hence, understanding the effect of sugar-sweetened coffee (SSC) consumption on blood sugar levels in patients with diabetes mellitus (DM) is important. This study was conducted using the Korea National Health and Nutrition Examination Survey data from 2008 to 2020.

Chitosan-Derived Porous Activated Carbon for the Removal of the Chemical Warfare Agent Simulant Dimethyl Methylphosphonate.

Methods for the rapid removal of chemical warfare agents are of critical importance. In this work, a porous activated carbon material (C-PAC) was prepared from chitosan flakes via single-step potassium carbonate (KCO) activation for the prompt adsorption of dimethyl methylphosphonate (DMMP). C-PAC samples were prepared using different carbonization temperatures (350, 550, and 750 °C) at a constant KCO/chitosan ratio (1:2) and using different activator ratios (KCO/chitosan ratios of 1:0.